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New function discovered in cancer-prevention protein
Date:6/10/2010

fact that p53 becomes activated during gametogenesis is something that has been conserved throughout evolution. The research team observed similar activations during the formation of spermatozoids in mice, which reaffirms the importance of this control mechanism.

The results of the study, published in Science, are revealing and help to understand more about the functions of this essential protein which stops the formation of tumours and therefore could open the door to new approaches in the study of cancer. The research describes for the first time the physiological role of p53 in the development of meiosis and suggests that the function of the tumour suppressor gene can be result of an evolution of primitive activities related with the progression of meiosis.


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Contact: Dr. John Abrams
John.Abrams@UTSouthwestern.edu
Universitat Autonoma de Barcelona
Source:Eurekalert

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