Navigation Links
New function discovered in cancer-prevention protein

Protein p53 is known as the guardian of the genome since it is basic for the genome's integrity by preventing the accumulation of mutations originating either by the cell's own mechanisms or by the action of external agents. The protein becomes activated in response to specific signals such as breaks in DNA. This activation implies a slowing of the cell's cycle which allows it to repair itself from the damage. If the damage is not repaired on time, the activation of p53 results in programmed cell death known as apoptosis. This causes the gene encoding the protein, which in humans is the TP53 gene, to be seen as a tumour suppressor since its inactivation can make it easier for many types of tumour cells to develop.

Scientists had long wondered about the origin and evolutionary appearance of this gene. From an evolutionary point of view it is understandable to think that p53 came into existence without necessarily acting as a tumour suppressor and, therefore, must have had other functions which until now remained unknown.

Through the observation of genetically modified flies to determine the activation of p53, the team led by Dr John Abrams of the University of Texas Southwestern Medical Center and with the participation of Dr Ignasi Roig from the Cytology and Histology Unit of the Department of Cellular Biology, Physiology and Immunology at Universitat Autnoma de Barcelona, discovered that p53 becomes activated during the formation of gametes (spermatozoa and ova). It becomes activated specifically during meiosis, the cell division process resulting in gametes. It is a moment in which the cell breaks DNA all along its genome. Repairing these breaks, which is essential for meiosis to complete correctly, must be controlled closely in order to prevent the accumulation of mutations and the possibility of their binding to the gametes. P53 is in charge of developing this process control mechanism.

Scientists additionally discovered that the fact that p53 becomes activated during gametogenesis is something that has been conserved throughout evolution. The research team observed similar activations during the formation of spermatozoids in mice, which reaffirms the importance of this control mechanism.

The results of the study, published in Science, are revealing and help to understand more about the functions of this essential protein which stops the formation of tumours and therefore could open the door to new approaches in the study of cancer. The research describes for the first time the physiological role of p53 in the development of meiosis and suggests that the function of the tumour suppressor gene can be result of an evolution of primitive activities related with the progression of meiosis.


Contact: Dr. John Abrams
Universitat Autonoma de Barcelona

Related medicine news :

1. Link established between erectile dysfunction and calcified coronary arteries
2. Pitt researchers discover gene mutation linked to lymphatic dysfunction
3. Henry Ford Hospital: New left-side heart pump improves right-side heart function
4. Can eGFR be a routine preoperative renal function test?
5. PET scanning probes reveal different cell function within the immune system
6. New evidence caffeine may slow Alzheimers disease and other dementias, restore cognitive function
7. A more active lifestyle crucial for day-to-day function in COPD patients
8. New study suggests sickle cell disease may affect brain function in adults
9. Physical therapist-led exercise in patients in ICU improves function and decreases hospital stay
10. Vital functions monitored with wearable and implantable devices
11. Preoperative MRI assists in surgical planning and helps spare erectile function after RALP
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... The Progressive Dental ... on January 29 and 30, 2016. The course welcomes dental professionals and members ... to learn how to better succeed in the modern dental marketplace. The course ...
(Date:11/30/2015)... ... , ... A record crowd gathered at the Pennsylvania Biotech Center of Bucks ... Blumberg Institute. , The institute, which is the research arm of the Hepatitis B ... the conference, which focused on ways companies can work to reduce the cost and ...
(Date:11/30/2015)... ... 30, 2015 , ... HemoTreat™ has announced that the company ... to its website. , “Our goal is simple:” says Michael Blasco, HemoTreat’s Chief ... comparison chart and ingredient list allows our customers to quickly see why, and ...
(Date:11/30/2015)... ... November 30, 2015 , ... ChiliPad ... looking to maximize recovery through quality sleep. Tim DiFrancesco, training coach for the ... better night’s sleep. ChiliPad precisely regulates the surface temperature of each side of ...
(Date:11/30/2015)... ... November 30, 2015 , ... Advocare ... centered orthopedic care. Led by John Vitolo, M.D., the center offers their ... the team at Advocare Orthopedic & Sports Medicine is ready to help their ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 30, 2015   VolitionRx Limited (NYSE MKT: VNRX), ... for a broad range of cancer types and other conditions, ... Conference, which will be held December 1 - 3 in in ... will be David Kratochvil , Chief Financial Officer and ... Relations. ® blood-based tests for colorectal cancer ...
(Date:11/30/2015)... LONDON , November 30, 2015 Mexico ... Healthcare and Life Sciences Report 2015 . --> Pharmaboardroom ... 2015 . Latin America , a country ... , a country of over 122 million people. --> ... in healthcare, pharmaceuticals, or life sciences insights into the second largest ...
(Date:11/30/2015)... SHELTON, Connecticut , November 30, 2015 ... Kentucky Breast Care has entered into a ... women,s healthcare practice. This will allow Kentucky Breast Care ... and offer exceptional care for their patients. ... Kentucky Breast Care has entered into a ...
Breaking Medicine Technology: