Navigation Links
New frontiers of fecal microbiota transplantation

Bethesda, MD (Aug. 14, 2014) Fecal microbiota transplantation (FMT) is one of the most innovative new treatments of the 21st century. Experts believe that this procedure, which transplants microbes from one human gut to another through fecal matter, could offer the cure to a vast range of diseases and shed new light on the role of the microbiome in gastrointestinal diseases. New research presented this weekend at the American Gastroenterological Association's 2014 James W. Freston Conference in Chicago, IL, highlights significant advances in this field, and confirms the promise of FMT to advance our understanding of GI disease and aid in the development of new microbiome-based therapeutics to treat a broad range of GI disorders.

"The 2014 AGA James W. Freston Conference promises to be an important and stimulating meeting in microbiome and FMT research and technology," said course directors Stacy A. Kahn, MD, and David T. Rubin, MD, AGAF, both from The University of Chicago Medicine. "This is the first international conference on FMT and brings together leaders from across the field and will highlight advances in basic science and clinical research. In addition, the conference will also create a forum to discuss the ethical and regulatory issues in this emerging field."

FMT Beyond C. Difficile

While FMT has been proven to be safe and effective for patients with recurrent C. difficile infection, its efficacy in treating other diseases is still in question. Data presented at the AGA James W. Freston Conference will provide evidence that FMT is an effective treatment for a range of other GI disorders. One study reports that 70 percent of subjects who received FMT for refractory irritable bowel syndrome (IBS) had a resolution and/or improved symptoms. Patients reported improved abdominal pain (72 percent), bowel habit (69 percent), dyspepsia (67 percent), bloating (50 percent) and flatus (42 percent). Quality of life was also improved in 46 percent of patients.

Data also confirm the potential for FMT in treating inflammatory bowel disease (IBD), both ulcerative colitis and Crohn's disease. A study out of Montefiore Medical Center finds that colonoscopic FMT, followed by self-administered fecal enemas, resulted in improved symptoms and decreased medication requirements, especially in IBD patients with concomitant C. difficile infection.

On the Horizon: Orally Delivered Microbes

FMT has multiple liabilities, including invasive delivery, cost and complexity of donor management, variability of FMT preparation, and the potential to transmit pathogens. A new study, to be presented at the meeting, holds the answer to these challenges an orally delivered community of microbes. SER---109, developed by Seres Health, Inc., proved to be remarkably efficacious and safe with a 100 percent cure rate for the treatment of recurrent C. difficile infection in the study population. The pill works to rapidly repair the microbial imbalance cause by chronic antibiotic treatment for C. difficile by inducing the formation of a diverse and healthy microbiome. This pill has the potential to replace FMT and maximize utility for clinicians and patients.

New Understanding of the FMT Patient

Due to the "yuck" factor, some patients and clinicians are reluctant to consider FMT. New data to be presented at the AGA James W. Freston Conference sheds light on the factors that lead to acceptance of FMT. The study found that patients who have children are more likely to accept FMT, suggesting that parents may be more willing to try emerging procedures for the sake of their children. Having a college degree was also a significant factor, implying that a better understanding of the disease may affect one's willingness to undergo FMT. The main concern for undergoing FMT was the risk of disease transmission. Since FMT is a potentially life-saving procedure, medical practitioners should use this knowledge when counseling patients and their families on the decision to undergo FMT.


Contact: Rachel Steigerwald
American Gastroenterological Association

Related medicine news :

1. Moffitt Cancer Center researchers working at frontiers of melanoma research
2. Frontiers launches new open-access journal: Frontiers in Pediatrics
3. Frontiers publishes systematic review on the effects of yoga on major psychiatric disorders
4. Moffitt Cancer Center researchers discuss new frontiers in breast cancer screening
5. Shopping Cart Software Provider, Shopping Cart Elite Officially Launches
6. DNDi receives the BBVA Foundation Frontiers of Knowledge Award in Development Cooperation
7. DIA to Host Annual Canadian Meeting: New Realities/New Frontiers
8. Caring for patients with fecal incontinence costs more than $4,000 per person each year
9. Groundbreaking clinical trial looks at fecal transplant as treatment for C. difficile
10. Fecal Transplant to Cure Gut Infection?
11. Fecal microbiota transplantation cures gastrointestinal diseases
Post Your Comments:
(Date:11/24/2015)... ... November 24, 2015 , ... New patients who wish to seek ... dental implants at her Mississauga, ON practice. Dr. Williams has been providing ... of dental implants. , Missing teeth can lead to a variety of complications ...
(Date:11/24/2015)... ... November 24, 2015 , ... Charitable giving is at its ... made in the last five weeks of the year totalling over $358 billion in ... to connect the nation’s charities with those individuals who want to “give back” during ...
(Date:11/24/2015)... Angeles, CA (PRWEB) , ... November 24, 2015 , ... ... explored the different restrictions and variables that determine which patients are or are not ... those patients that have a BMI over 40, are more than 100 pounds overweight, ...
(Date:11/24/2015)... ON (PRWEB) , ... November 24, 2015 , ... DMG ... with Ed Begley Jr., airing first quarter 2016 via Discovery Channel. Dates and show ... of the Province, and is in the business of producing and supplying medical marijuana ...
(Date:11/24/2015)... Falls Church, VA (PRWEB) , ... November 24, 2015 , ... ... 2015 — 1:30 p.m. – 3:00 p.m. EST, , FDA has ... device regulations. CLIA regulations apply to performing the tests and do not meet the ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... CHICAGO , Nov. 24, 2015  Figure 1, ... view and share medical cases, has launched a new ... of the web version allows radiologists, who work primarily ... workstation. To further engage with its radiologist user base, ... Society of North America (RSNA) ...
(Date:11/24/2015)... , Nov. 24, 2015 Teledyne DALSA , ... image sensing technology, will introduce its CMOS X-Ray detector ... , November 29 to December 3, at McCormick Place in ... detectors for diagnostic and interventional imaging will be on display ... family of advanced CMOS X-Ray detectors is the industry ...
(Date:11/24/2015)... Nov. 24, 2015  NuShield, Inc., an industry leader in LCD screen protection and glare-elimination technology, ... technology as part of their patient monitoring or electronic documentation system. ... ... ... A study in 2013 ...
Breaking Medicine Technology: