Navigation Links
New form of stem cell communication rescues diseased neurons
Date:2/1/2010

LA JOLLA, Calif., February 1, 2010 -- Investigators at Sanford-Burnham Medical Research Institute (Sanford-Burnham, formerly Burnham Institute for Medical Research), the Karolinska Institutet, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School and Universit Libre de Bruxelles have demonstrated in mouse models that transplanted stems cells, when in direct contact with diseased neurons, send signals through specialized channels that rescue the neurons from death. These direct cell-to-cell connections may also play a role in normal development by laying down the blueprint for more mature electrical connections between neurons and other cells. The research was published in the journal Proceedings of the National Academy of Sciences on February 1.

While it was already known that stem cells will seek out diseased cells in the brain, the international group of scientists showed, both in tissue culture and in mice, that the stem cells actively bring diseased neurons back from the brink via cross-talk through gap junctions, the connections between cells that allow molecular signals to pass back and forth. Significantly, the stem cells do not need to differentiate into the specific type of neuron to provide this therapeutic effect. The researchers also believe this protective mechanism may be active in other cell types and play a role in many diseases. For example, some of their preliminary work shows that these mechanisms may rescue damaged neural fibers in adult spinal cord injuries.

"We showed a while ago that stems cells may exert a therapeutic effect on damaged or diseased host systems by secreting therapeutic factors and 'bathing' the dying cells," said Evan Snyder, M.D., Ph.D., director of the Stem Cell and Regenerative Biology program at Sanford-Burnham. "However, we did not know that stem cells can also exert their action through direct cell-to-cell contact. Indeed, we believe that this may be a newly-recognized way in which stem cells communicate with the cells around them, not only under diseased conditions but during normal development."

"Grafted neural stem cells of mouse and human origin make early gap junction contact with cells in the host brain that benefit endangered host neurons, even rescuing them from impending cell death," added Richard L. Sidman, M.D., Professor of Neuropathology (Neuroscience) at BIDMC, Boston and Harvard Medical School.

Beginning with tissue culture studies, the team found that neural stem cells (NSCs, including human NSCs) integrated into the neural circuitry, coordinated signaling (as measured by calcium fluxes) and protected injured neurons. The team replicated these findings in diseased mice (including those that have a disorder similar to Huntington's disease) and spinal-injured rats. The scientists, led by Eric Herlenius, Ph.D., of the Karolinska Institutet and Dr. Snyder, hypothesized that communication through gap junctions was the mechanism for the protective effect. Subsequently, the researchers disabled gap junctions, which diminished the therapeutic effect and validated the gap junction hypothesis.


'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Related medicine news :

1. IABC Cleveland Presents The Changing Face of Health Care Communications at Feb. 18 Luncheon
2. Gordon S. LaVigne Appointed ALS Association Chief Development and Communications Officer
3. Emerson Network Power Unveils DP40 Power Supply Series for Medical, IT and Telecommunications Applications
4. Huntington Hospital Uses New Technology to Assist Nurses; Voalte iPhone Application Improves Critical Communication at Point-of-Care
5. Music therapy can assist toddlers communication rehabilitation process
6. Lifespace Communities Selects StaffKnex Software for Nurse Scheduling and Employee Communications
7. New Report Examines the Role of Communications Technologies in Humanitarian Crises
8. Wisconsin Department of Transportation Chooses EF Johnson Technologies, Inc. for Statewide First Responder Communications System in $13.2 Million Contract
9. LodgeNet Interactive to Participate in UBS 37th Annual Global Media and Communications Conference
10. Live Webinar: Pandemic + Recession = Webcasting: Cost-Effective Streaming for Public Health Communications
11. Lexi-Comp Focused on Improving Patient Communication in Healthcare Institutions Treating Diverse Patient Populations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... Dr. Poneh Ghasri, cosmetic ... treatments to both new and existing patients. Cosmetic dentistry allows patients to improve the ... have healthy smiles with some minor or more serious cosmetic flaws. These specials allow ...
(Date:5/3/2016)... ... May 03, 2016 , ... Celestix ... announced the new SecureAccess feature for its CelestixEdge solution. CelestixEdge is the ... enable organizations to get the DirectAccess user experience on unsupported DirectAccess clients ...
(Date:5/3/2016)... , ... May 03, 2016 , ... ... helps healthcare organizations, especially medium and small physician practices, to better grasp and ... unique step-by-step approach that guides practices on a well-defined, expert-created path to compliance. ...
(Date:5/2/2016)... ... May 03, 2016 , ... RNK Products, Inc. (RNK) ... software that enables the stethoscope stream to go over the video conferencing audio ... flagship PCP-USB stethoscope. , Remote auscultation involves two software elements on the PC: ...
(Date:5/2/2016)... ... May 02, 2016 , ... The ... Patient Experience Journal (PXJ), an international, open access, peer-reviewed journal focused on research ... issue representing international (non-US) based authors, the third volume of PXJ continues to ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... NEW YORK , May 2, 2016 ... the EMR (Electronic Medical Records) market in a recent ... International sales, vendor switches, Increased physician usage, a growing market ... trends were noted in Kalorama,s report EMR ... The report marks Kalorama,s seventh complete study of the ...
(Date:5/2/2016)...  Celsion Corporation (NASDAQ: CLSN ), an ... the first cohort of patients in its Phase ... combining GEN-1, the Company,s DNA-based immunotherapy, with the ... patients with advanced ovarian cancer who will undergo ... the first three patients dosed, GEN-1 plus standard ...
(Date:4/29/2016)... April 29, 2016 Acquisition ... Sciences, Product Development Capabilities in North ... Base . Indegene ( http://www.indegene.com ... the acquisition of Skura Corporation,s life science business. ... adaptive sales enablement technology for life science organizations ...
Breaking Medicine Technology: