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New findings show Enbrel significantly reduced levels of C-reactive protein
Date:2/1/2008

risk for developing conditions such as cardiovascular disease that may derive from increased systemic inflammation.

The analysis also evaluated the relationship between CRP levels and body mass index (BMI), an indicator of body fat, in people with psoriasis without psoriatic arthritis. Notably, obesity is common among patients with psoriasis. Findings showed:

  • Heavier patients with higher BMIs tended to have higher CRP levels.

  • ENBREL decreased CRP levels in overweight and obese psoriasis patients. Specifically, among patients treated with ENBREL, median CRP values decreased from high or intermediate levels to intermediate or low levels after 12 weeks of treatment in all BMI groups except normal weight psoriasis patients.

The 24-week registrational study was originally designed to test the efficacy and safety of ENBREL therapy in patients with moderate to severe plaque psoriasis, the results of which have previously been reported in The New England Journal of Medicine. The primary objective of this retrospective analysis was to evaluate the effectiveness of ENBREL in reducing levels of CRP in psoriasis patients with and without psoriatic arthritis from baseline to week 12 compared to placebo. Secondary objectives were to assess CRP values at baseline, and to assess the relationship between CRP levels and patient characteristics, such as BMI, use of statin drugs, and Psoriasis Area and Severity Index (PASI). During the double-blind portion of the analysis, patients were randomly assigned to receive either placebo or ENBREL injections (25 mg once weekly, 25 mg twice weekly or 50 mg twice weekly) for 12 weeks. During the subsequent 12 weeks, patients who initially received ENBREL continued to receive treatment with ENBREL at the same dose, while patients in the placebo group switched to ENBREL 25 mg twice weekly.

ABOUT C-REACTIVE PROTEIN

CRP is a blood protein that is a marker for a
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Contact: Sonia Fiorenza
fiorenza@amgen.com
805-447-1604
Porter Novelli
Source:Eurekalert

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