Navigation Links
New findings on the brain's immune cells during Alzheimer's disease progression
Date:4/11/2013

The plaque deposits in the brain of Alzheimer's patients are surrounded by the brain's own immune cells, the microglia. This was already recognized by Alois Alzheimer more than one hundred years ago. But until today it still remains unclear what role microglia play in Alzheimer's disease. Do they help to break down the plaque deposit? A study by researchers of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch and Charit Universittsmedizin Berlin has now shed light on these mysterious microglia during the progression of Alzheimer's disease. (PLOS One, doi:10.1371/journal.pone.0060921)*

Dr. Grietje Krabbe of the laboratory of Professor Helmut Kettenmann (MDC) and Dr. Annett Halle of the Neuropathology Department of the Charit headed by Professor Frank Heppner demonstrated that the microglial cells around the deposits do not show the classical activation pattern in mouse models of Alzheimer's disease. On the contrary, in the course of the Alzheimer's disease they lose two of their biological functions. Both their ability to remove cell fragments or harmful structures and their directed process motility towards acute lesions are impaired. The impact of the latter loss-of-function needs further investigation. The plaques consist of protein fragments, the beta-amyloid peptides, which in Alzheimer's disease are deposited in the brain over the course of years. They are believed to be involved in destroying the nerve cells of the affected patients, resulting in an incurable cognitive decline.

However, just why the microglial cells, which cluster around the deposits, are inactivated or lose their functionality is still not fully understood. The researchers concluded that this process occurs at a very early stage of disease development and is likely triggered by the beta-amyloid. This is confirmed by the fact that the loss-of-function of the microglial cells in the mice could be reversed by beta-amyloid antibodies thereby decreasi
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Recent Research Findings Suggest that Weight Loss Supplements Like Clear Cleanse Pro May Remove “Obesity Microorganisms” from Your Body
2. Nutralife Hails New Study’s Findings on SAM-e, Giving Hope to Millions Seeking Joint Relief
3. Author of new breast cancer study comments on its findings of increased risk
4. For the first time, recommendations offer guidance about incidental genetic findings
5. Kessler Foundation researchers share findings in rehabilitation research at AAN meeting in San Diego
6. TGen findings highlighted at 7th annual cancer conference
7. AIDS journal publishes findings of 2 important studies in Mar. 2013 issue
8. Independent panel to present findings on diagnosing gestational diabetes mellitus
9. Researchers uncover new findings on genetic risks of Behçets disease
10. Pitt/UPMC team describes findings from BCI study in spinal cord-injured man in PLoS One
11. Study Says Timing of Lunch May Impact Weight Loss – Celebrity Beverly Hills Doctor Discusses the Findings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 21, 2014 Today, Fecbek.com, a leading ... new designs of wedding dresses. And all these elegant, ... designed by excellent designers. , A wedding dress or ... during a wedding ceremony. Color, style and ceremonial importance ... culture of the wedding participants. In order to satisfy ...
(Date:8/20/2014)... IL (PRWEB) August 21, 2014 Most ... but the summer months often get overlooked for a ... most important for food pantries. Understanding this need, ... local chiropractic & natural health care center, wanted to ... Their clinic hosted its first annual Thanksgiving in July ...
(Date:8/20/2014)... Skmen.com, the popular online supplier of men’s and women’s clothes, ... online. Along with this, the company has also launched ... fresh products are offered with great discounts and low shipping ... before August 31. , Skmen.com has more than 200 ... proportion of its clothes are selling well in the current ...
(Date:8/20/2014)... In less than a week the airwaves will ... fight muscle related disease. Helping the huge telethon effort ... through their cause-related marketing heft. With their help – ... $60 million. , But for small self-serve business entrepreneurs ... marketing remains decidedly local and, although the money they ...
(Date:8/20/2014)... August 21, 2014 PAINWeek, the ... announced that Ethan Nadelmann, JD, PhD, will deliver ... is the founder and executive director of the ... United States promoting alternatives to the war on ... reform, both domestically and internationally, he has played ...
Breaking Medicine News(10 mins):Health News:Elegant Wedding Dresses Are for Sale at Fecbek.com 2Health News:AlignLife Springfield Office Donates 565 Canned Goods to Springfield Food Pantry 2Health News:Skmen.com: New Designs Of Mini Party Dresses Provided Online 2Health News:On Eve of Big Telethon, Froyo Businesses Participate but Also Go Their Own -- Local Way 2Health News:On Eve of Big Telethon, Froyo Businesses Participate but Also Go Their Own -- Local Way 3Health News:PAINWeek Welcomes Ethan Nadelmann, JD, PhD, as Keynote Speaker at 2014 Conference 2
... scientists, there are two types of acute lymphoblastic leukaemia ... cells are those that have a pre-existing immunity to ... relapse after treatment. ,The discovery means that ... will specifically target these resistant subclones so that, in ...
... to a study by the Canadian Institute for Health Information ... //in London is more than double than that of Toronto's ... ,The study, released yesterday, reveals the seriousness of ... emergency departments after ladder accidents, an average of 23 a ...
... launched in Rajasthan and it could hit your stores soon. ... properties, it is now the turn of ice cream that ... cream comes in two flavours - kesar and strawberry vanilla. ... (LPPS), an NGO that supports landless livestock owners. ...
... team at Brunel University to help people ridden on wheelchair to ... a day. // ,Presently patients are asked to ... program may soon change all that. It requires only a standard ... ,This would enable doctors to build up information on ...
... containing parts of diptheria toxin as a way to prompt ... patients suffering from advanced melanoma (Skin Cancer) ,In ... test the drug denileukin diftitox (also known as DAB (389) ... with stage IV disease experienced significant regression or stabilisation of ...
... be set for clinical software used by doctors, AMA ... ,The use of clinical software packages is expanding rapidly ... standards and the lack of standardised testing of clinical ... ,'The AMA is calling for a national ...
Cached Medicine News:Health News:'Good' And 'Evil' Clones Of Acute Lymphoblastic Leukaemia cells 2Health News:'Good' And 'Evil' Clones Of Acute Lymphoblastic Leukaemia cells 3Health News:Season for Ladder Accidents!! 2Health News:Ice Cream made of Camel Milk Launched in Rajasthan 2Health News:Pain Tracked By 3D Computer Map 2Health News:Diptheria Toxin And Interleukin2 Help Killing Melanoma Tumour Cells 2
(Date:8/20/2014)... NEW YORK , Aug. 20, 2014 /PRNewswire/ ... report is available in its catalogue: ... http://www.reportlinker.com/p01375204/Global-Coatings-for-Medical-Devices-Industry.html This ... Medical Devices in US$ Million by the following ... and Nanotechnology Coatings. The report provides separate comprehensive ...
(Date:8/20/2014)... , Aug. 20, 2014  Amerigen Pharmaceuticals Ltd. ... Co. Ltd., has received Chinese FDA (CFDA) approval ... mg Tablets into the China ... marketing and distribution agreement with Sinochem Jiangsu Pharmaceutical ... its US FDA approved and China CFDA certified ...
(Date:8/20/2014)... WORTH, Fla. , Aug. 20, 2014  Glades Drugs, ... , is proud to announce its expansion into a ... , which will feature an 8,000-square-foot office space and state ... currently accepting applications for 100 open positions for the new ... at 4560 Lantana Road will serve as the chain,s corporate ...
Breaking Medicine Technology:Global Coatings for Medical Devices Industry 2Global Coatings for Medical Devices Industry 3Global Coatings for Medical Devices Industry 4Global Coatings for Medical Devices Industry 5Global Coatings for Medical Devices Industry 6Global Coatings for Medical Devices Industry 7Global Coatings for Medical Devices Industry 8Global Coatings for Medical Devices Industry 9Global Coatings for Medical Devices Industry 10Global Coatings for Medical Devices Industry 11Global Coatings for Medical Devices Industry 12Global Coatings for Medical Devices Industry 13Global Coatings for Medical Devices Industry 14Global Coatings for Medical Devices Industry 15Global Coatings for Medical Devices Industry 16Global Coatings for Medical Devices Industry 17Global Coatings for Medical Devices Industry 18Global Coatings for Medical Devices Industry 19Global Coatings for Medical Devices Industry 20Global Coatings for Medical Devices Industry 21Amerigen Pharmaceuticals Ltd. announces that its Chinese subsidiary, Suzhou Amerigen Pharmaceuticals Co. Ltd., has received Chinese FDA (CFDA) approval and has subsequently launched its generic Mecobalamin 0.5 mg Tablets into the China domestic mark 2Glades Drugs Moves to New Corporate Headquarters, 100 Open Positions 2
... INDIANAPOLIS, Oct. 21 More than 25 Eli Lilly and ... will celebrate "Energy Day," which is a new corporate sustainability ... energy reduction goals and to encourage sustainable behaviors. ... years early. Over a five-year period, from 2004 to 2008, ...
... , SOUTH SAN FRANCISCO, Calif., Oct. 21 NGM ... discovery and development of novel biotherapeutics for the treatment ... announced that Arthur D. Levinson, Ph.D., the Chairman of ... Board of Directors. Under Dr. Levinson,s leadership as ...
Cached Medicine Technology:Lilly Surpasses Energy Efficiency Goals and Celebrates Worldwide Energy Day 2NGM Biopharmaceuticals Appoints Dr. Arthur D. Levinson, Former Genentech CEO, to its Board of Directors 2NGM Biopharmaceuticals Appoints Dr. Arthur D. Levinson, Former Genentech CEO, to its Board of Directors 3
... yet, the all-new Assure Pro Blood Glucose ... growing demands of the Long-Term Care profession. ... backlighting, and strip release offer better convenience, ... insert the test strip in the convenient ...
... For practices performing routine Holter,monitoring, ... QuickStep Wizard provides a,practical, no-nonsense ... managed health care,environment. This highly ... in a variety,of configurations at ...
... The Vision5L ... high-quality 5- or ... with a signal ... transfer using a ...
... II features a diagnostic interpretation,option ... Glasgow,(UG) algorithm. Unlike competitive products,which ... the UG,algorithm bases its analysis ... age, race, medication,and classification., Plus ...
Medicine Products: