Navigation Links
New findings on men's genes could alter interpretation of PSA test
Date:10/30/2012

By studying a specific part of the male DNA, it may be possible to refine the interpretation of PSA tests. This would reduce the risk of men being treated for prostate cancer unnecessarily.

The findings have been presented in a thesis by Christel Bjrk at Lund University, Sweden, who has carried out the study with her colleague Hannah Nenonen, supervised by researcher Yvonne Lundberg Giwercman.

A PSA test measures the level of PSA (prostate-specific antigen) in the blood, and raised PSA can signal an increased risk of cancer; however, this is not the case for everyone. The problem is that there is no good way to separate those with naturally high levels of PSA from those at increased risk of prostate cancer.

"If we know that a man has a naturally high level of PSA, this can be taken into account in a PSA test, and the patient may be able to avoid arduous treatment with a risk of side-effects", says Christel Bjrk, a doctoral student at the Department of Clinical Sciences, Lund University.

The present study shows how a man's genetic characteristics can affect the androgen receptor, a protein that has an important function in the male reproductive system. It regulates the effect of testosterone and controls production of prostate-specific antigen. The researchers studied healthy men in different age groups and discovered a connection between PSA levels in the blood and DNA structure of the androgen receptor. The highest PSA levels were found in the men with the most common variant of the androgen receptor, i.e. the largest group of men.

"Both the PSA level and the genetic characteristics can be identified with a blood test", says Yvonne Lundberg Giwercman, Associate Professor at the Department of Clinical Sciences, Lund University.

The study is based on samples from around 400 men from Sweden and Norway. Before the results can be implemented for PSA tests in the health service, the study must be repeated on a larger group.

"We have access to material covering around 3 200 men from seven European countries and the idea is to investigate whether our preliminary findings can be verified on this group in the near future", explains Yvonne Lundberg Giwercman.


'/>"/>
Contact: Yvonne Lundberg Giwercman
Yvonne.Giwercman@med.lu.se
46-705-977-904
Lund University
Source:Eurekalert

Related medicine news :

1. Unexpected findings at multi-detector CT scans: Less reason to worry
2. MRI findings shed light on multiple sclerosis
3. New findings by GW researcher break tanning misconceptions: There is no such thing as a safe tan
4. Relief for Migraine Sufferers as The Life House Offers New Findings, Free Consults
5. Columbus Allergist Dr. Summit Shah Discusses Recent Findings on Food Allergies and Exercise-Induced Anaphylaxis
6. Once-Banned Bird Flu Study Yields Sobering Findings
7. Mayo Clinic urologists present findings at American Urological Association Annual Meeting
8. Researchers present new findings for novel pancreatic cancer vaccine
9. Kessler Foundation scientists present cognitive research findings at MS dual symposium
10. New findings in breast cancer
11. Tying the Knot Ups Womens Drinking Rate, Lowers Mens
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , ... Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , ... our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, ... the latter, setting the bar too high can result in disappointment, perhaps even self-loathing. ... toward their goal. , Research from PsychTests.com reveals that behind the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... , , , WHEN: ... , , , , LOCATION: , , , Online, with ... , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice ... Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... industry is witnessing an exceptional era. Several new demand spaces, such ...
(Date:6/23/2016)... June 23, 2016  Guerbet announced today that it ... Supplier Horizon Award . One of 12 ... recognized for its support of Premier members through exceptional ... excellence, and commitment to lower costs. ... recognition of our outstanding customer service from Premier," says ...
Breaking Medicine Technology: