Navigation Links
New findings on men's genes could alter interpretation of PSA test
Date:10/30/2012

By studying a specific part of the male DNA, it may be possible to refine the interpretation of PSA tests. This would reduce the risk of men being treated for prostate cancer unnecessarily.

The findings have been presented in a thesis by Christel Bjrk at Lund University, Sweden, who has carried out the study with her colleague Hannah Nenonen, supervised by researcher Yvonne Lundberg Giwercman.

A PSA test measures the level of PSA (prostate-specific antigen) in the blood, and raised PSA can signal an increased risk of cancer; however, this is not the case for everyone. The problem is that there is no good way to separate those with naturally high levels of PSA from those at increased risk of prostate cancer.

"If we know that a man has a naturally high level of PSA, this can be taken into account in a PSA test, and the patient may be able to avoid arduous treatment with a risk of side-effects", says Christel Bjrk, a doctoral student at the Department of Clinical Sciences, Lund University.

The present study shows how a man's genetic characteristics can affect the androgen receptor, a protein that has an important function in the male reproductive system. It regulates the effect of testosterone and controls production of prostate-specific antigen. The researchers studied healthy men in different age groups and discovered a connection between PSA levels in the blood and DNA structure of the androgen receptor. The highest PSA levels were found in the men with the most common variant of the androgen receptor, i.e. the largest group of men.

"Both the PSA level and the genetic characteristics can be identified with a blood test", says Yvonne Lundberg Giwercman, Associate Professor at the Department of Clinical Sciences, Lund University.

The study is based on samples from around 400 men from Sweden and Norway. Before the results can be implemented for PSA tests in the health service, the study must be repeated on a larger group.

"We have access to material covering around 3 200 men from seven European countries and the idea is to investigate whether our preliminary findings can be verified on this group in the near future", explains Yvonne Lundberg Giwercman.


'/>"/>
Contact: Yvonne Lundberg Giwercman
Yvonne.Giwercman@med.lu.se
46-705-977-904
Lund University
Source:Eurekalert

Related medicine news :

1. Unexpected findings at multi-detector CT scans: Less reason to worry
2. MRI findings shed light on multiple sclerosis
3. New findings by GW researcher break tanning misconceptions: There is no such thing as a safe tan
4. Relief for Migraine Sufferers as The Life House Offers New Findings, Free Consults
5. Columbus Allergist Dr. Summit Shah Discusses Recent Findings on Food Allergies and Exercise-Induced Anaphylaxis
6. Once-Banned Bird Flu Study Yields Sobering Findings
7. Mayo Clinic urologists present findings at American Urological Association Annual Meeting
8. Researchers present new findings for novel pancreatic cancer vaccine
9. Kessler Foundation scientists present cognitive research findings at MS dual symposium
10. New findings in breast cancer
11. Tying the Knot Ups Womens Drinking Rate, Lowers Mens
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... “Three Narrow ... Roads” is the creation of published author, Rev. Dr. Burnett King Sr., is currently ... coach and founder of the Faith Track Club, Inc., a track-and-field program geared towards ...
(Date:8/18/2017)... ... August 18, 2017 , ... Rollon Skin Care Ltd., ... solutions, recently announced the launch of two new skincare products, Prache Antiaging ... alternative to expensive plastic surgery or in-patient cosmetic dermatological procedures. , “We are ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Steve the Snake”: an entertaining and moral-based ... the creation of published author, Harold Flash Haskins Jr., a husband, father and grandfather ... police officer. , “I write moral-based short stories for children and teens. My goal ...
(Date:8/17/2017)... , ... August 17, 2017 , ... ... health care organizations and considered extremely effective, very effective, or effective by 85% ... Physician Leadership”. , NEJM Catalyst Insights Reports are based on surveys of the ...
(Date:8/17/2017)... ... August 17, 2017 , ... Industry CEOs, life ... for Anti-Infectives Rx. This off-the-record networking forum of the Boston Biotech Conference series ... School. , Industry leaders and decision makers will discuss issues facing the development ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Calif. , Aug. 15, 2017  AOTI Inc. announced today ... Oxygen Therapy Inc., has recently opened a New York City Office ... ever-increasing usage of its unique Topical Wound Oxygen (TWO 2 ) ... by the Accreditation Commission for Health Care (ACHC) under the company,s ... ...
(Date:8/10/2017)... 10, 2017  Physical Rehabilitation Network (PRN), acquired the long-standing ... Lakewood, Colorado . The reputable clinic will continue to ... DPT with his staff of four clinicians. Lipkin received his ... brings over 10 years of experience with a strong background ... PT marks the 10th PRN clinic in and around the ...
(Date:8/7/2017)... 7, 2017 Insightin Health, provider of ... and engagement, announced the selection of Michael ... Development, effective as of February 2017. In this role, ... strategy for our clients. Wood brings with him ... and business analytics within the healthcare industry. Wood ...
Breaking Medicine Technology: