Navigation Links
New findings on men's genes could alter interpretation of PSA test

By studying a specific part of the male DNA, it may be possible to refine the interpretation of PSA tests. This would reduce the risk of men being treated for prostate cancer unnecessarily.

The findings have been presented in a thesis by Christel Bjrk at Lund University, Sweden, who has carried out the study with her colleague Hannah Nenonen, supervised by researcher Yvonne Lundberg Giwercman.

A PSA test measures the level of PSA (prostate-specific antigen) in the blood, and raised PSA can signal an increased risk of cancer; however, this is not the case for everyone. The problem is that there is no good way to separate those with naturally high levels of PSA from those at increased risk of prostate cancer.

"If we know that a man has a naturally high level of PSA, this can be taken into account in a PSA test, and the patient may be able to avoid arduous treatment with a risk of side-effects", says Christel Bjrk, a doctoral student at the Department of Clinical Sciences, Lund University.

The present study shows how a man's genetic characteristics can affect the androgen receptor, a protein that has an important function in the male reproductive system. It regulates the effect of testosterone and controls production of prostate-specific antigen. The researchers studied healthy men in different age groups and discovered a connection between PSA levels in the blood and DNA structure of the androgen receptor. The highest PSA levels were found in the men with the most common variant of the androgen receptor, i.e. the largest group of men.

"Both the PSA level and the genetic characteristics can be identified with a blood test", says Yvonne Lundberg Giwercman, Associate Professor at the Department of Clinical Sciences, Lund University.

The study is based on samples from around 400 men from Sweden and Norway. Before the results can be implemented for PSA tests in the health service, the study must be repeated on a larger group.

"We have access to material covering around 3 200 men from seven European countries and the idea is to investigate whether our preliminary findings can be verified on this group in the near future", explains Yvonne Lundberg Giwercman.

Contact: Yvonne Lundberg Giwercman
Lund University

Related medicine news :

1. Unexpected findings at multi-detector CT scans: Less reason to worry
2. MRI findings shed light on multiple sclerosis
3. New findings by GW researcher break tanning misconceptions: There is no such thing as a safe tan
4. Relief for Migraine Sufferers as The Life House Offers New Findings, Free Consults
5. Columbus Allergist Dr. Summit Shah Discusses Recent Findings on Food Allergies and Exercise-Induced Anaphylaxis
6. Once-Banned Bird Flu Study Yields Sobering Findings
7. Mayo Clinic urologists present findings at American Urological Association Annual Meeting
8. Researchers present new findings for novel pancreatic cancer vaccine
9. Kessler Foundation scientists present cognitive research findings at MS dual symposium
10. New findings in breast cancer
11. Tying the Knot Ups Womens Drinking Rate, Lowers Mens
Post Your Comments:
(Date:10/13/2015)... GA (PRWEB) , ... October 13, 2015 , ... ... nonprofit promoting the establishment of telemedicine programs in communities throughout Georgia, along with ... announce the collective schedule for their regional telehealth summits for Fall 2015. ...
(Date:10/13/2015)... ... October 13, 2015 , ... According to an ESPN ... orbital fracture when a teammate accidentally elbowed him in the left eye during the ... injury is just one of a series of setbacks, including a knee injury that ...
(Date:10/13/2015)... ... October 13, 2015 , ... In an ... PediaPlex , a Southlake, Texas, child development and pediatric therapy center, is ... educating military families about their options for receiving this kind of care for ...
(Date:10/13/2015)... Niguel, CA (PRWEB) , ... October 13, 2015 ... ... tools, announced the release of a new PDF automation tool to batch ... regulations, and business mandates with 100% document fidelity. , CADConverter eliminates the complexity ...
(Date:10/13/2015)... , ... October 13, 2015 , ... ... winning programs Elder Care Doula Training and End of Life Doula Training. ... a holistic model, physically, spiritually and emotionally. Based on her #1 International ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 8, 2015 Research and Markets ( ... Anti-counterfeit Pharmaceuticals and Cosmetics Packaging - Market Opportunities and ... --> --> ... at a CAGR of 15.7% during 2015-2020 ... technology segment accounted for about 52% share in 2014 ...
(Date:10/12/2015)... the United States . By early next ... --> the United States . By early next ... --> The University of Texas MD Anderson Cancer Center, Elekta ... (1.5 Tesla) MRI-guided linear accelerator in the United States ... in a non-clinical capacity. Royal Philips (NYSE: ...
(Date:10/12/2015)... COSTA MESA, Calif. , Oct. 12, 2015 ... reaffirmed the accreditation of Harbor Compounding Pharmacy in ... accreditation is awarded in recognition of the pharmacy,s ... --> ... --> ...
Breaking Medicine Technology: