Navigation Links
New findings on drug tolerance in TB suggest ideas for shorter cures
Date:3/3/2011

researchers draw another picture of what might be happening in TB. They described the existence of multi-drug tolerant organisms that form within days of infection in zebrafish, an animal model for studying TB. However, they were surprised to see this bacterial population actively growing and reproducing inside of host macrophages "big eater" white blood cells that engulf germs and debris in the body. In fact, the drug-tolerant bacteria not only thrive within these disease-fighting clean-up cells, but also co-opt them to carry the transiently drug resistant TB infection to other parts of the body. There they help promote its continuation inside of granulomas the nodules in the lung characteristic of TB.

To understand how growing bacteria might be tolerant to drugs, the authors turned to studying the human TB bacillus in human macrophages. They found that upon infecting macrophages, the bacteria deploy a structure called an efflux pump. The authors found that these pumps are essential for the TB bacteria to grow within macrophages and are turned on possibly to get rid of host antimicrobial substances targeted to penetrate the bacteria and destroy them.

Paradoxically it is the infected macrophage itself that stimulates the efflux pumps in the bacteria. The TB cell efflux pumps can also flush away medications, a mechanism, the researchers say, which may be contributing to multi-drug tolerance.

"Thus the TB drugs get caught in the crossfire in this pitched battle between bacterium and host," Ramakrishnan said.

Certain inexpensive medications are already available that can inhibit these bacterial pumps and thereby reduce multi-drug tolerance, the researchers noted. One of these is the calcium channel blocker verapamil, which is used to treat high blood pressure, angina, and some heart rhythm problems.

The researchers suggest that adding this currently approved drug to TB therapy, or working to develop drugs tha
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Latest findings of Dartmouth HIV/AIDS study could turn treatment on its head
2. Research provides new findings on drug delivery with nanoparticles
3. SMFM highlights significance of spina bifida research findings
4. Most Guidelines for Infectious Diseases Dont Come From Clinical Trial Findings
5. International research team reports major findings in prevention and treatment of blood clots
6. VCU findings may help explain some major clinical symptoms of preeclampsia
7. Addiction research: Key findings every month
8. Encouraging findings suggest new avenues for treating liver disease in overweight Americans
9. Latest Findings Back Mammograms for Women in Their 40s
10. National committee releases findings on transforming and improving the nursing profession
11. Study findings show value of dietary supplement SAMe in treatment of adults with major depressive disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New findings on drug tolerance in TB suggest ideas for shorter cures
(Date:7/12/2014)... 12, 2014 (HealthDay News) -- Burn injuries increase in the ... grills, say burn experts. Among those most vulnerable to these ... most vulnerable and often get burned by putting their hands ... director of the burn unit at Loyola University Medical Center ... "The old adage of ,When you play with fire, you ...
(Date:7/12/2014)... New York, New York (PRWEB) July 12, 2014 ... ) continue to move forward in U.S. courts, Bernstein ... that ties elevated metal ion levels to the failure ... the July 2nd issue of The Journal of Bone ... had received unilateral Articular Surface Replacement prostheses at ...
(Date:7/12/2014)... PA (PRWEB) July 12, 2014 Doylestown ... covering a variety of men’s health questions. Paddock ... specific to men, why women live longer than men, ... Men's Health Made Simple featured on Doylestown ... get a hernia at any age. If you notice ...
(Date:7/12/2014)... Praeclarus Press is excited to offer ... resource for women in need of lactation support. Statistics ... from their children. Today’s mothers receive very clear messages ... often feel unsupported when it comes to balancing working ... insights, and written by Nancy Mohrbacher, an international breastfeeding ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 The largest ... Centers, is pleased to announce that it will be ... This new facility will join four Atlanta-based Nova Medical ... located at 3209 Deans Bridge Road, and will be ... Friday. , “With Nova’s treatment philosophy of rapid ...
Breaking Medicine News(10 mins):Health News:Burn Injuries More Common in Summer 2Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 2Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 3Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 4Health News:Ivyland Medical Center’s Dr. Brad Paddock Offers Tips for Men’s Health 2Health News:Praeclarus Press Announces the Release of Working and Breastfeeding Made Simple by Nancy Mohrbacher, A Much Needed Resource For Today's Working Mothers 2Health News:Nova Medical Centers To Open New Facility in Augusta, Georgia 2
... are at risk of pre-eclampsia, a complication of pregnancy, in time ... risk factor that can be detected many weeks before symptoms appear ... developed pre-eclampsia had higher-than-normal levels of a protein called SHBG early ... Pre-eclampsia is seen in about 5% ...
... more than 100 years. And while most of the popular ... use of aspirin has increased. This powerful pill will //reduce ... risk of heart attacks and stroke. ,In the ... first discovered, relatively few drugs have been developed that can ...
... Supplements containing bacteria commonly found in yogurt can help ... a day. Researchers reviewed 11 international// studies that examined ... Lactobacillus for the treatment of diarrhoea in children, most ... hospitalized. The Lactobacillus was generally given as a supplement, ...
... other biological weapons continue to be worrisome threats, common ... and cheaper// than current treatments in eradicating deadly bacterial ... used for more than 50 years to control insect ... is a better option than current treatments such as ...
... Institute, chemists have tricked an enzyme essential in ... A team led by Nobel laureate K. Barry ... to make a molecule that blocks neurotransmitter destruction ... destructive enzyme catalyzes the so-called "click reaction" that ...
... in combination with calcium citrate and vitamin D ... increase spinal bone mass in older women with ... Texas Southwestern Medical Center concluded. ,Our study ... the risk for fractures by stimulating new bone ...
Cached Medicine News:Health News:Researchers trick Alzheimer's Enzyme 2
(Date:7/10/2014)... , July 10, 2014  Breg, Inc., a ... has launched the FreeRunner™ knee brace with new ... from patella mal-tracking return to active lifestyles.  FreeRunner,s ... other braces, providing support when patients need it ... they don,t. Patellofemoral issues are the ...
(Date:7/10/2014)... July 10, 2014  Valeant Pharmaceuticals International, Inc. (NYSE: ... it has completed the sale to Galderma of all ... or held by Valeant for $1.4 billion in cash, ... which recently completed its acquisition of Galderma. ... our products to a company that is firmly committed ...
(Date:7/10/2014)... , July 10, 2014 Decision Resources Group ... of the U.S. Food and Drug Administration,s (FDA) approval ... binder Velphoro, which was approved by the FDA in ... kidney disease (CKD) patients on dialysis. Other ... Nephrology (US) Q2 2014 : ...
Breaking Medicine Technology:Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3
... Congress wraps up work on health care reform, members ... Committee arrived on Capitol Hill today to discuss the ... ensure kidney transplant recipients continue to receive Medicare coverage ... for Kidney Transplant Patients Act of 2009 , in ...
... Ethicon Endo-Surgery today announced the company won a ... research and design process used in the development of ... recognized among thousands of entries for its innovative use ... surgeons across the globe to identify specific unmet needs ...
Cached Medicine Technology:AST on Capitol Hill to Promote Transplant Drug Extension Provision With Senate as Part of Health Care Reform 2Ethicon Endo-Surgery Wins Prestigious International Design Award for Innovative Development of HARMONIC FOCUS(TM) 2Ethicon Endo-Surgery Wins Prestigious International Design Award for Innovative Development of HARMONIC FOCUS(TM) 3
... Designed to inform decision ... complete patient data on demand. ... access to lab results, medication ... allergy profiles, and clinical notes ...
... The SJM Tailor Flexible Band ... a convenient and time-saving alternative for ... It complements the SJM Tailor® Annuloplasty ... who usually implant full rings, but ...
... Focus from Thermo Labsystems was designed specifically ... Advanced features such as the new fast ... on microvolumes help to define this as ... The new interchangeable handle plate offers a ...
... from Thermo Labsystems was designed specifically to ... features such as the new fast dial ... microvolumes help to define this as a ... new interchangeable handle plate offers a custom ...
Medicine Products: