Navigation Links
New findings on drug tolerance in TB suggest ideas for shorter cures
Date:3/3/2011

New findings on how tuberculosis (TB) bacteria develop multi-drug tolerance point to ways TB infections might be cured more quickly.

The study will be published April 1 in the journal Cell. The results identify both a mechanism and a potential therapy for drug tolerance that is induced in the TB bacteria by the host cells they infect.

Currently, TB treatment requires a complex, long-term curative regimen of at least six months, explained the senior author of the study, Dr. Lalita Ramakrishnan, University of Washington (UW) professor of medicine, microbiology and immunology. Her lab conducted the study in collaboration with Dr. Paul Edelstein, of the Department of Pathology and Laboratory Medicine at the University of Pennsylvania.

Many months of TB treatment are needed because the bacteria become tolerant to TB drugs. In the first couple days of treatment the bacteria die rapidly, but the death rate then slows to a crawl as the bacteria become resistant to killing. This tolerance to antibiotics occurs despite the absence of genetic mutations for drug resistance.

The authors noted that adhering to six months of drug treatment is difficult, particularly in areas of the world where TB is prevalent.

"Breaks in treatment can lead to relapses that perpetuate the TB epidemic and also fuel the development of genetic resistance to treatment," Edelstein said.

An urgent goal of scientists is to overcome drug tolerance, yet most of the drugs in development will not shorten the lengthy treatment. This failure results from a poor understanding of the mechanism of TB tolerance.

"Drug tolerance," Ramakrishnan said, "has been largely attributed to TB bacteria that are dormant in the body and not reproducing. These postulated dormant bacteria are thought to be unaffected by the administered antibiotics that are most effective against rapidly growing organisms"

In this latest study, the
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related medicine news :

1. Latest findings of Dartmouth HIV/AIDS study could turn treatment on its head
2. Research provides new findings on drug delivery with nanoparticles
3. SMFM highlights significance of spina bifida research findings
4. Most Guidelines for Infectious Diseases Dont Come From Clinical Trial Findings
5. International research team reports major findings in prevention and treatment of blood clots
6. VCU findings may help explain some major clinical symptoms of preeclampsia
7. Addiction research: Key findings every month
8. Encouraging findings suggest new avenues for treating liver disease in overweight Americans
9. Latest Findings Back Mammograms for Women in Their 40s
10. National committee releases findings on transforming and improving the nursing profession
11. Study findings show value of dietary supplement SAMe in treatment of adults with major depressive disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New findings on drug tolerance in TB suggest ideas for shorter cures
(Date:5/25/2013)... 25, 2013 Imagine running the air conditioner ... loss, hot air and wasted energy! If the home has ... fireplace or clothes dryer, that may be just what is ... often overlooked holes waste energy in the form of higher ... cooling loss in the home. , Drafts occur through the ...
(Date:5/25/2013)... AZ (PRWEB) May 25, 2013 An ... service page in partnership with JD Media Surge, LLC. ... methods are now available and, depending on the treatment, ... During a routine visit, the best method will be ... is performed during a visit. A special peroxide-based whitening ...
(Date:5/25/2013)... May 25, 2013 Actos lawsuit ... in U.S. District Court, Western District of Louisiana, continue ... to a Case Management Order issued on May 21st, ... of contested motions in the Actos bladder cancer litigation, ... re: Actos Product Liability Litigation, MDL No. 2299) , ...
(Date:5/25/2013)... Forney, United States (PRWEB) May 25, 2013 ... oldest and largest underground shelter company in the ... and composite underground structures for over 35 years. ... of PROTECTION, U.S. Handbook of NBC Weapon Fundamentals ... is the United States’ bible on shelter engineering. ...
(Date:5/25/2013)... May 25, 2013 On May 20, 2013 ... do not wish to discuss or plan for their eventual ... FuneralFinancials.com released a Must-Do List to help people ... Financials recommends, “Creating a personal fact sheet.” , While not ... financial information and personal data. It may include a ...
Breaking Medicine News(10 mins):Health News:How To Stop Drafts and Save On Home Energy Bills This Summer - New Draft Stoppers Now Available From Battic Door Energy Conservation 2Health News:How To Stop Drafts and Save On Home Energy Bills This Summer - New Draft Stoppers Now Available From Battic Door Energy Conservation 3Health News:How To Stop Drafts and Save On Home Energy Bills This Summer - New Draft Stoppers Now Available From Battic Door Energy Conservation 4Health News:Chandler Dentist Launches Teeth Whitening Service Page on Website in Partnership with JD Media Surge, LLC 2Health News:Actos Lawsuit News: Bernstein Liebhard LLP Notes New Case Management Order in Federal Actos Bladder Cancer Litigation 2Health News:Actos Lawsuit News: Bernstein Liebhard LLP Notes New Case Management Order in Federal Actos Bladder Cancer Litigation 3Health News:Radius Engineering International Inc. Offers Tools to Stay Safe and Recover From Any Disaster 2Health News:Radius Engineering International Inc. Offers Tools to Stay Safe and Recover From Any Disaster 3Health News:FuneralFinancials.com Releases Last Wishes Must-Do List 2
... Genetic Testing IndustryWALTHAM, Mass., Feb. 2 Interleukin ... that Chief Executive Officer Lewis H. Bender will ... Financial Strategies for Molecular Diagnostics conference, taking place ... presentation is scheduled for Wednesday, February 4 at ...
... Ask for Provisions in Stimulus Package to Help ... than 57,000 new jobs, 26,800 of which will ... in the United States through the Renewable ... to Congress and the Administration by Health Care ...
... 2 AMDL, Inc. (NYSE,Alternext US: ADL), a vertically ... announced today its Chairman and CEO Mr.,Douglas MacLellan will ... (3:40 a.m.,PT) today, February 2, 2009. , ... expert on Fox Business News to,discuss the current business ...
... to Florida to Open its Doors, with Ceremonies at 103,000-Square-Foot Facility ... ... 2009 -- More than 200 community, government and science leaders celebrated ... Studies, (TPIMS) headquarters in the Florida Center for Innovation at ...
... Network" to serve Healthcare Industry , ... ... Marketing Solutions LLC today announced partnerships with several leading ... MindSet,s geoMEDICX Zip+4 and Zip code targeting tags and offer ...
... ... Denver, CO (PRWEB) February 2, 2009 -- Susan Cordts, ... in an exclusive interview with Mary Jo Nott and the BeyeNETWORK ... predict who to target with what product, identifying what media with ...
Cached Medicine News:Health News:Interleukin Genetics to Present at G-2 Reports' Molecular Diagnostic Conference 2Health News:Healthcare Sector Leaders Urge Obama, Congress to Invest in Alternative Energy and Green Jobs in Healthcare 2Health News:Healthcare Sector Leaders Urge Obama, Congress to Invest in Alternative Energy and Green Jobs in Healthcare 3Health News:AMDL Chairman & CEO Mr. Douglas MacLellan Featured on Fox Business News Monday February 2, 2009 2Health News:Torrey Pines Institute for Molecular Studies Opens New Headquarters in Florida 2Health News:Torrey Pines Institute for Molecular Studies Opens New Headquarters in Florida 3Health News:Mindset Marketing Solutions Partners with Platform-A, ValueClick Media, AdRX Media, Datran Media and Morefocus Media 2Health News:Mindset Marketing Solutions Partners with Platform-A, ValueClick Media, AdRX Media, Datran Media and Morefocus Media 3Health News:ATi Tailored BI and Advanced Predictive Analytics Solutions Improve Marketing Response Rates 2Health News:ATi Tailored BI and Advanced Predictive Analytics Solutions Improve Marketing Response Rates 3
(Date:5/24/2013)... , May 24, 2013  An international roster ... Saturday, May 18, in Santa Monica, Calif. ... new lung-sparing therapies for MPM, a rare form of ... affects the pleura, the lining of the chest. ... and Blood Institute, the 3rd Annual International Symposium on ...
(Date:5/24/2013)... 2013  Auxilium Pharmaceuticals, Inc. (Nasdaq: AUXL ... the Deutsche Bank Health Care Conference to be held ... Adrian Adams , Chief Executive Officer ... the Company and its product pipeline at 12:00 p.m. ... (Logo: http://photos.prnewswire.com/prnh/20101202/MM10881LOGO ) The presentation will ...
(Date:5/24/2013)... The potential of the pulmonary route as ... has been receiving undeniable attention with the recent advances ... crucial formulation considerations for orally inhaled products together with ... in the efficiency of pulmonary delivery, and great strides ... techniques and devices in recent years. With ...
Breaking Medicine Technology:International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 2International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 3Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 2Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 3Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 4Inhalaltion Drug Delivery: 11-12 September - Berlin, Germany 2
... and cesarean section trials in conjunction with David ... G. Genecov, MD, FACS, FAAP to begin immediately, ... BIEL), the maker of the ActiPatch(TM), a drug free ... pulse therapy specifically designed to speed healing, today,announced world ...
... CARMEL, Israel, May 28 , - Study ... Non-Invasive,MRgFUS to Those who had Invasive Fibroid Surgery, ... Food and Drug,Administration (FDA) cleared the company to ... safety of the ExAblate(R) 2000 system utilizing,MR-guided Focused ...
Cached Medicine Technology:BioElectronics Announces Major Clinical Trials 2BioElectronics Announces Major Clinical Trials 3BioElectronics Announces Major Clinical Trials 4FDA Clears ExAblate Fertility Enhancement Study in Women With Uterine Fibroids 2FDA Clears ExAblate Fertility Enhancement Study in Women With Uterine Fibroids 3FDA Clears ExAblate Fertility Enhancement Study in Women With Uterine Fibroids 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: