Navigation Links
New findings in breast cancer
Date:4/18/2012

s with tumorigenic potential," Bissell says. "This casts doubt on the current hypothesis of hierarchical or differentiative loss of tumorigenicity."

The marker used by the Petersen-Bissell collaboration to isolate the luminal-like cancer cells was milk mucin (MM), one of the glycans, the sugar molecules that are ubiquitous to cell surfaces and central to cellular signaling. Basal-like cancer cells were marked with the protein CD271. The MM glycan was detected by the antibody M18. The CD271 marker was detected by the ME20.4 antibody.

In their investigation, the collaborators found that the ability of the luminal-like breast cancer cells to form large invasive tumors depended on the expression of the glycoprotein gene GCNT1, which in turn is required for the MM glycan to be detected by the M18 antibody. The collaborators believe this finding might be of potential clinical importance for breast cancer as co-author Kuhn, a member of Bissell's research group, explains.

"There has been an increasing appreciation that glycans play an important role in malignant behavior and our work shows that inhibiting the activity of GCNT1 could prevent the invasive behavior of the aggressive luminal-like cancer cells if they express the MM epitope," she says.

While Petersen emphasizes that any clinical implications of this work remains speculative at this time, the finding that multiple types of cells in breast cancers are capable of initiating invasive tumors, he says, could hold implications for future personalized medicine.

"While new avenues in breast cancer targeting have been strongly influenced by the concepts of tumor subtypes and cancer stem cells, we believe our data and recent data from other laboratories opens the possibility of targeting individual stages of differentiation of breast cancer cells within a tumor," Petersen says. "In that way personalized medicine in the future could rely on a cellular-composition-profile with e
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
2. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
3. VARI findings may help patients with deadly kidney cancer
4. UMass Lowell researchers findings suggest new ways to diagnose and treat Alzheimers
5. Research findings expected to ease treatment of low neutrophil counts in cancer patients
6. Cedars-Sinai Heart Institute physicians present findings at ACC scientific meeting
7. Research findings underscore needed action to safeguard lungs of young cancer survivors
8. Those with allergic asthma face double trouble during flu season, UT Southwestern findings suggest
9. Findings suggest optimal dose
10. VARI findings could help diagnose and treat liver cancer
11. Brain MRI in children: Incidental findings yield disclosure dilemmas for doctors, patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New findings in breast cancer
(Date:9/21/2014)... Faculty and staff at Garrison Forest School ... Owings Mills, Md., kicked off the academic year by taking ... is the first independent school to receive the bands— which ... sleep patterns— as part of a pilot program with ... specialty chain. The Vivofit bands are just one tool in ...
(Date:9/21/2014)... (PRWEB) September 21, 2014 According to latest ... the highest birth rate since 1966 (10.5 births per 1,000 ... their early 40s has risen steadily by 2 percent per ... births to women aged 50 and over) also rose, the ... there were more than nine times as many first births ...
(Date:9/20/2014)... iFitDress.com, a well-known wedding dress manufacturer and retailer, has unveiled ... addition, the company has launched a special offer on the ... benefit all of its big fans. Worldwide people can buy ... Along with beautiful party dresses, the company also offers many ... new sexy short prom outfits and purple homecoming gowns online; ...
(Date:9/20/2014)... 2014 Diabetes Protocol , a ... is helping thousands of people learn how to naturally ... pills, or prescriptions has caught the attention of Shane ... currently tens of millions of people in the U.S. ... 2 diabetes, and unfortunately, big pharma makes a killing ...
(Date:9/20/2014)... 6 Minutes to Skinny , a fat loss ... is showing men and women of all ages how they ... using simple 6-minute exercises and easy-to-follow lifestyle tips daily, has ... , “When it comes to losing body fat, unfortunately ... all people,” reports Michaels. “Metabolism plays a big role in ...
Breaking Medicine News(10 mins):Health News:Garrison Forest School Leader in Independent School Wellness Programs 2Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 2Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 3Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 4Health News:Beautiful Party Dresses For Autumn Unveiled By iFitDress.com 2Health News:Diabetes Protocol: Review Exposes Kenneth Pullman’s Breakthrough Discovery About Diabetes Management 2Health News:6 Minutes to Skinny: Review Exposes Craig Ballantyne’s Method to Jump Starting the Metabolism and Blasting Away Body Fat in Just 6 Minutes Per Day 2
... Konica Minolta Sensing Americas,Inc. (KMSA), the ... color,light and shape, announces the launch of ... product used in combination with Konica Minolta,s,portable ... simultaneously with a numerical display of the ...
... By playing it safe and using a two-pronged attack, a ... tested by an international team of researchers led by the ... similar to components of viruses and in this way alerts ... against cancer cells in this process. At the same time, ...
... Nurses Association to Ask Voters ... to Think of Health Care, TRENTON, N.J., Nov. 1 ... Ladies have,joined forces to ask the state,s public policy makers to ... and federal level. The First Ladies,joined the newest members of the ...
... , , SATURDAY, Nov. 1 (HealthDay News) -- Personalized treatment ... a UCLA study of almost 1,500 patients that identified ... to be treated accordingly. , The UCLA team said ... to be changed. , "We have shown that not ...
... the #1 position among detox procedures for opiate addiction, there is a ... , ... Palm Beach, FL (PRWEB) November 1, 2008 -- The primary ... as Meditox of Palm Beach that offer it? The drug can ...
... of nearly 1,500 patients treated for kidney cancer at ... aggressive, tailored treatment approach results in better survival rates ... and need to be treated accordingly. , The one-size-fits-all ... changed based on the results of the study, the ...
Cached Medicine News:Health News:Konica Minolta Sensing Americas Announces the Launch of the CM-SA Skin Analysis Software 2Health News:Substance tackles skin cancer from 2 sides 2Health News:On Weekend Before the Election, New Jersey's First Ladies Speak Out for Healthcare 2Health News:On Weekend Before the Election, New Jersey's First Ladies Speak Out for Healthcare 3Health News:Tailored Treatment Boosts Kidney Cancer Survival 2Health News:Suboxone Fast Passing Methadone As Preferred Method Of Treatment For Opiate Detox 2Health News:Landmark UCLA study finds aggresive, personalized treatment increases kidney cancer patient survival 2Health News:Landmark UCLA study finds aggresive, personalized treatment increases kidney cancer patient survival 3
(Date:9/19/2014)... , Sept. 19, 2014 Larry J. ... CVS ), will speak before the National Press Club ... discuss the company,s recent move to stop selling tobacco products ... the future of health. "Dramatic changes in our ... care providers and government," Merlo has said. "CVS Health has ...
(Date:9/19/2014)... 19, 2014  Pressure BioSciences, Inc. (OTCQB: PBIO) ... received and approved all parts required to build ... begun to manufacture the new PCT-based instrument system.  ... ready for shipment by mid-October and that additional ... a rate of about one per week thereafter.  ...
(Date:9/19/2014)... MINNEAPOLIS and ORLANDO, Fla. ... data supporting Inspire therapy continues to grow, with the ... paper published on-line in Otolaryngology – Head ... therapy causes a worsening of both objective and subjective ... to directly attribute Inspire therapy for the reduction in ...
Breaking Medicine Technology:CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 3Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4
... LH Ovulation Predicting Test is a qualitative ... Hormone (hLH) in human urine to predict ... by the elevation of human luteinizing hormone ... period starts, hLH has a brief, significant ...
The Pach IV is the premier product for cornea thickness measurement in conjunction with Glaucoma screening....
... The Shandon Varistain 24-4 ... stainer designed to offer simplicity ... cytology staining applications. It is ... load and continuous throughput. ...
The Shandon Linistat Linear Stainer is a compact answer to H&E frozen section protocols, with a footprint that fits on top of most cryostas to streamline workflow during frozen sectioning....
Medicine Products: