Navigation Links
New findings could influence the development of therapies to treat dengue disease
Date:8/2/2013

New research into the fight against Dengue, an insect-borne tropical disease that infects up to 390 million people worldwide annually, may influence the development of anti-viral therapies that are effective against all four types of the virus.

The findings, led by researchers at the University of Bristol and published in the Journal of Biological Chemistry today [2 August], show for the first time that there may be significant differences in specific properties of the viral proteins for the four dengue virus types.

Due to the effects of globalisation, including increased travel and urbanisation of human populations and the expanded geographical distribution of the mosquito vector that is responsible for the transmission of viral infections to millions of people, the number of individuals afflicted with dengue is rising.

Infection with any one of the four types of dengue virus (DENV types 1 - 4) may result in a spectrum of illnesses ranging from dengue fever, a mild flu like illness which causes high fever and joint pains, to the potentially fatal dengue haemorrhagic fever. Despite intensive research, dengue disease is not wholly understood, and there are no vaccines or anti-viral treatments available that can safely or effectively control the disease.

Dr Andrew Davidson, Senior Virologist and lead researcher from the University of Bristol, and colleagues examined the nuclear localisation properties of the NS5 protein of all four DENV types and found that there are major differences in the cellular localisation of the viral NS5 protein for the four DENV types.

The four types of DENV are genetically distinct. Although they can all cause dengue disease, little is known about how the genetic differences between them may translate into differences in virus replication and pathogenesis.

Previous studies by the team focusing on DENV-2, have shown that the viral NS5 protein is essential for DENV genome replication and is able
'/>"/>

Contact: Philippa Walker
philippa.walker@bristol.ac.uk
44-117-928-7777
University of Bristol
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New findings in breast cancer
2. Kessler Foundation scientists present cognitive research findings at MS dual symposium
3. Researchers present new findings for novel pancreatic cancer vaccine
4. Mayo Clinic urologists present findings at American Urological Association Annual Meeting
5. Once-Banned Bird Flu Study Yields Sobering Findings
6. Columbus Allergist Dr. Summit Shah Discusses Recent Findings on Food Allergies and Exercise-Induced Anaphylaxis
7. Relief for Migraine Sufferers as The Life House Offers New Findings, Free Consults
8. New findings by GW researcher break tanning misconceptions: There is no such thing as a safe tan
9. MRI findings shed light on multiple sclerosis
10. Unexpected findings at multi-detector CT scans: Less reason to worry
11. New findings on mens genes could alter interpretation of PSA test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... November 22, 2014 Domestic farmgate ... slightly in 2009-10, due to a fall in ... industry products amid the global financial crisis. ... strength of Australian dairy manufacturers on the international ... products outweighed supply growth, primarily due to supply ...
(Date:11/22/2014)... Everett, WA (PRWEB) November 22, 2014 The ... beauty and complexity of block retaining walls. The article states ... strength, there are several necessary steps that go into creating ... steps when building a retaining wall is choosing which kind ... desired purpose. , B&D Rockeries says, “The two main ...
(Date:11/22/2014)... has been a historical time for Angeldress.co.uk, an excellent wedding ... some renowned review websites. Recently, the company has added to ... of wonderful sexy wedding dresses to its website. At the ... to an 80% discount on any order over GBP 149. ... dress at Angeldress.co.uk, which has garnered a hard core of ...
(Date:11/22/2014)... 22, 2014 Recently, UWDress.com is gratified ... guest dresses . In addition, the company has also ... , As a leading online supplier of wedding dresses, ... outfits. The unusual best wedding guest gowns are provided ... amazing designs, this new selection is famous for high ...
(Date:11/22/2014)... OR (PRWEB) November 22, 2014 The ... of Roy Baroff to its team of conflict ... mediator, soccer player, coach, and referee. He has over 30 ... Carolina and beyond. , “I'm very excited to connect with ... and sports related interests to a program with a complete ...
Breaking Medicine News(10 mins):Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:5 Step Installment of Block Retaining Walls is Topic of Latest Article by B&D Rockeries 2Health News:Sexy Wedding Dresses with Special Discounts Launched by Angeldress.co.uk 2Health News:Best Wedding Guest dresses Introduced by UWDress.com 2Health News:SCI Announces New Team Member Roy Baroff 2Health News:SCI Announces New Team Member Roy Baroff 3
... Infectious Diseases (NIAID), part of the National Institutes of Health, ... shut down, and how they can be reactivated. ... that the immune system can use, like the gas pedal ... or to damp down its activity. However, in people with ...
... FRIDAY, June 3 (HealthDay News) -- Poor sleep may be ... research that found that children who bully other kids are ... In the study, researchers from the University of Michigan Medical ... twice as likely to have sleep-disordered breathing problems or ...
... Sexual pleasure among young adults (ages 18-26) is linked to ... by researchers at the Johns Hopkins Bloomberg School of Public ... representative population sample of heterosexuals to find a relationship between ... published in the June 2011 issue of The Journal ...
... tsunami, tornado or flood strike, among the most vulnerable ... Journal of Emergency Management , researchers in New Zealand ... the age-related needs of adults with regards to the ... Tuohy and Christine Stephens of Massey University in Palmerston ...
... early days of the AIDS epidemic, a once-rare form of ... harbinger of HIV. Its stigma was best illustrated by Tom ... cancerous skin lesions from his co-workers in the 1993 movie ... Zhu was a young virologist searching for a postdoctoral position. ...
... Reporter , THURSDAY, June 2 (HealthDay News) -- The emergence ... bacteria in Europe should serve as a red flag for ... and changing. They,re not necessarily becoming more severe, but they ... physician in infectious diseases at North Shore University Hospital in ...
Cached Medicine News:Health News:Kids Who Bully Often Get Poor Sleep 2Health News:Study links empathy, self-esteem, and autonomy with increased sexual enjoyment 2Health News:Helping the aged during natural disasters 2Health News:FSU scientist leads research on AIDS-related cancer 2Health News:FSU scientist leads research on AIDS-related cancer 3Health News:Deadly E. Coli Strain in Europe Should Serve as Warning, Experts Say 2Health News:Deadly E. Coli Strain in Europe Should Serve as Warning, Experts Say 3
(Date:11/21/2014)...  The acceptance of two abstracts on the ... demonstrates continued interest in the Eclipse System, the ... of the abstracts, presented by Catherine Matthews ... Urogynecology and Reconstructive Pelvic Surgery at the University ... Written Abstract on Urogynecology/Pelvic Floor Disorders/Vaginal Surgery. ...
(Date:11/21/2014)... , Nov. 20, 2014 Oxis International, Inc. (OXIS) ... the election of Anthony J. Cataldo as Chief ... Effective November 19, 2014, Ken Eaton resigned ... Board of Directors of Oxis International, Inc. to pursue new ... been named Chief Executive Officer of Oxis International, Inc. Mr. ...
(Date:11/18/2014)... 2014  NxStage ® Medical Inc. (Nasdaq: ... innovative dialysis products , today announced the ... for the in-center, hemodialysis market.  Streamline Express features ... to reduce the amount of labor required for ... touch point contamination sites.  The dialyzer enables achievement ...
Breaking Medicine Technology:LIFE Study Prominently Featured at Minimally Invasive Gynecology Conference 2LIFE Study Prominently Featured at Minimally Invasive Gynecology Conference 3OXIS International, Inc. announces Changes in Management Team 2OXIS International, Inc. announces Changes in Management Team 3NxStage Launches New Streamline Express Dialyzer With Pre-attached Blood Tubing Set 2
... VEGAS, Sept. 15 At its regularly scheduled meeting ... American Pacific Corporation (the "Company" or "AMPAC") (Nasdaq: ... Recommended that shareholders at the next Annual ... 80% vote requirement for director election with a simple ...
... Sept. 15 Tunnell Consulting, Inc. announced ... with Campbell Informatics, an integrated services and technology company ... leading life sciences industry consultancy, and Campbell, a provider ... and regulators, is designed to enable both companies to ...
Cached Medicine Technology:American Pacific Adopts Corporate Governance Changes 2Tunnell Consulting Forms Strategic Alliance With Ireland-Based Campbell Informatics 2
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Each handle is designed to fit a specific trephine size....
Each handle is designed to fit a specific trephine size....
Medicine Products: