Navigation Links
New findings: The anti-fibrotic mechanism of plant extract Cpd 861
Date:4/30/2008

In human hepatic stellate cells, the key cells involved in both the synthesis and degradation of matrix proteins (mainly collagens) in the liver, the plant extract Cpd 861 can regulate the expression levels of collagen synthesis and degradation-related genes, thus demonstrating an antifibrotic effect.

This research, performed by Dr. Xue-Hai Tan and his colleagues at the Beijing Genomics Institute, was published on March 21, 2008, in the World Journal of Gastroenterology.

Hepatic fibrosis, which can lead to portal hypertension or cirrhosis, is a wound-healing response to chronic liver injuries due to a variety of insults. The altered balance between the synthesis and degradation of matrix proteins (mainly collagens) is the major pathogenic feature in the hepatic fibrosis process. Although remarkable progress has been made recently in understanding the mechanisms of hepatic fibrosis and while numerous agents have been studied, very few effective antifibrogenic drugs have been approved for use in humans.

Previous research has showed that Cpd 861, which was formulated by one the authors (Dr. Bao-En Wang) in accordance with traditional Chinese medical theory, can significantly improve the clinical manifestations and biochemical parameters of patients with hepatic fibrosis. Their recent work found that the antifibrotic function of Cpd 861 is mediated not only by inhibiting collagen synthesis (by downregulating collagen type III gene expression) but also by enhancing the degradation of collagens (by increasing the expression of matrix metalloproteinase-1, which is an enzyme that degrades collagens). These effects are different from those of Western antifibrogenic drugs (such as interferon- gamma).

The authors explain that the herbs used to prepare Cpd 861 have been used for thousands of years in Traditional Chinese Medicine, and the results of this research could allow for the development of effective antifibrogenic drugs from Chi
'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
2. Scientists discover a mechanism that can send cells on the road to cancer
3. Mosquito mating mechanism could lead to new attack on dengue and yellow fever
4. Researchers Define Mechanism of Methamphetamine Addiction
5. Study identifies mechanism underlying multidrug resistance in fungi
6. Increased hepcidin expression: A novel oncogenic signalling mechanism
7. Researchers describe mechanisms by which capon gene causes heart rhythm disturbances
8. Novel mechanism found that may boost impaired function of leukemia protein
9. Mechanism of blood clot elasticity revealed in high definition
10. Who found some new mechanisms of HBV virulence?
11. Japan Backs Away from Making Real Changes to Its Rx Pharma Pricing Mechanism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... (Boston) Emergency Medical Service (EMS) responders felt better ... receiving focused tactical training according to a new study ... This is the first study to specifically examine the ... scene where a shooter has not yet been neutralized ... , Incidents such as the Columbine High School shooting, ...
(Date:7/10/2014)... baby" an infant seemingly cured of HIV that was reported ... infection in The New England Journal of Medicine ... two years of not taking antiretroviral therapy without evidence of ... in the case. , "Certainly, this is a ... staff involved in the child,s care, and the HIV/AIDS research ...
(Date:7/10/2014)... of Huddersfield could help to improve the quality of ... such as butter, mayonnaise, yoghurt and fruit drinks ... for her work. , Katerina gained her MSc degree ... now she has embarked on research for a PhD. ... is investigating the potential of carbohydrates extracted from the ...
(Date:7/10/2014)... men with localized prostate cancer were more likely ... received less effective treatments and survived for shorter ... depressed, a UCLA study has found. , The ... factors such as bias against the mentally ill, ... man,s lack of investment in his general health ...
(Date:7/9/2014)... DC (July 10, 2014) If you think winning is ... for kids think again: Winning along with other mental bonuses ... of which falls into one of 11 big fun factors, ... winning is all important when it comes to the "fun" ... and quantify what goes into this elusive conceptuntil now. , ...
Breaking Medicine News(10 mins):Health News:Active shooter training increases comfort level of emergency responders 2Health News:'Mississippi Baby' now has detectable HIV, researchers find 2Health News:'Mississippi Baby' now has detectable HIV, researchers find 3Health News:World interest in research work on the benefits of the Okra plant 2Health News:Depressed men with prostate cancer are diagnosed later stage, get less effective therapies 2Health News:Being a good sport ranks as the top 'fun' factor in study of youth sports 2Health News:Being a good sport ranks as the top 'fun' factor in study of youth sports 3
... Republic International Corporation (NYSE: ORI ) ... of the regular quarterly cash dividend of 17 cents per ... 2009 to shareholders of record on March 4, 2009.The latest ... approved for the second quarter of 2008. The rate ...
... as Asian AffiliateNEW YORK and SINGAPORE, Feb. 26 ... prevention services, has signed an affiliation agreement with ... group based in Singapore and a subsidiary of ... medicine programs throughout Asia. Under the agreement, ParkwayHealth ...
... 274 adults with intellectual disabilities currently receiving funding ... , Washington, DC(February 23, 2009)The Supports Intensity ... for people with intellectual disability based on individual ... tool, unlike adaptive behavior instruments or other measures ...
... the UCSF-Gladstone Institute for Virology and Immunology Center for ... of the next generation of HIV/AIDS researchers and clinician ... in the American Journal for Public Health ... the AJPH website, the program focuses on overcoming challenges ...
... PARK, Ill., Feb. 26 Abbott ( NYSE: ABT ),today ... (AMO). AMO is now a wholly owned subsidiary of ... The acquisition of AMO enhances and strengthens ... leadership position in the large and,growing eye care market. ...
... today announced results for the fourth quarter and year ended December 31, 2008. Highlights from continuing operations for the ... Financial Results, (amounts in millions, except per share amounts), ... Q4 ... ...
Cached Medicine News:Health News:U.S. Preventive Medicine(R), ParkwayHealth Sign Affiliation Agreement to Jointly Deliver Preventive Medicine Services in Asia 2Health News:U.S. Preventive Medicine(R), ParkwayHealth Sign Affiliation Agreement to Jointly Deliver Preventive Medicine Services in Asia 3Health News:Supports Intensity Scale is effective for identifying needs in people with intellectual disability 2Health News:Effective mentoring critical to HIV/AIDS research efforts 2Health News:Abbott Completes Acquisition of Advanced Medical Optics 2Health News:Carriage Services Announces Fourth Quarter 2008 Results 2Health News:Carriage Services Announces Fourth Quarter 2008 Results 3Health News:Carriage Services Announces Fourth Quarter 2008 Results 4Health News:Carriage Services Announces Fourth Quarter 2008 Results 5Health News:Carriage Services Announces Fourth Quarter 2008 Results 6Health News:Carriage Services Announces Fourth Quarter 2008 Results 7Health News:Carriage Services Announces Fourth Quarter 2008 Results 8Health News:Carriage Services Announces Fourth Quarter 2008 Results 9Health News:Carriage Services Announces Fourth Quarter 2008 Results 10Health News:Carriage Services Announces Fourth Quarter 2008 Results 11Health News:Carriage Services Announces Fourth Quarter 2008 Results 12Health News:Carriage Services Announces Fourth Quarter 2008 Results 13Health News:Carriage Services Announces Fourth Quarter 2008 Results 14Health News:Carriage Services Announces Fourth Quarter 2008 Results 15Health News:Carriage Services Announces Fourth Quarter 2008 Results 16Health News:Carriage Services Announces Fourth Quarter 2008 Results 17
(Date:1/14/2014)... Dynamic Healthcare Services, Inc. ("DHS"), a portfolio company of ... Home Medical Equipment, Inc. ("Progressive") of Clarion, PA ... acquisition were not disclosed. Progressive is a ... range of sleep, mobility, and respiratory products to customers in ...
(Date:1/14/2014)... , Jan. 14, 2014 Animal Emergency Critical Care, a ... Leesburg, Virginia is the first in ... chamber. Dr. Susan M. Barnes , Medical ... Barnes and husband, Dr. Cole Taylor , are avid scuba ...
(Date:1/14/2014)... NineSigma , Inc., the leading innovation partner to organizations ... May 14-16, 2014 at the Global Center for Health ... This is the premier industry event for ... open innovation. Participants will learn how world-changing innovation is ...
Breaking Medicine Technology:Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... HOFFMAN ESTATES, Ill., Nov. 10 Life Spine announced ... Invasive Spinal System. The AVATAR MIS ... screws. Combining the novel screw delivery system with ... designed to accommodate evolving surgical approaches, as well as ...
... MedPro Imaging, a premium provider of new and refurbished ... MC Ultrasound, a leading on-site ultrasound provider for high ... area. The acquisition marks yet another milestone in MedPro ... its commitment of providing quality ultrasound imaging solutions. , ...
Cached Medicine Technology:MedPro Imaging Acquires MC Ultrasound 2
Non-Illuminated Trial Lens Set is an attractive set of trial lenses worked to a high standard of accuracy....
Trial Lens Sets....
... disc test (P/N LD15C) include a durable ... instructions. P/N LD15C also includes a Plexiglas ... covers for the test subjects fingers ( ... color discs). Beware that these finger cots ...
Opti-Free Express multi-purpose disinfecting solution lasting comfort No Rub formula provides triple action protection for your contact lenses....
Medicine Products: