Navigation Links
New findings: The anti-fibrotic mechanism of plant extract Cpd 861
Date:4/30/2008

In human hepatic stellate cells, the key cells involved in both the synthesis and degradation of matrix proteins (mainly collagens) in the liver, the plant extract Cpd 861 can regulate the expression levels of collagen synthesis and degradation-related genes, thus demonstrating an antifibrotic effect.

This research, performed by Dr. Xue-Hai Tan and his colleagues at the Beijing Genomics Institute, was published on March 21, 2008, in the World Journal of Gastroenterology.

Hepatic fibrosis, which can lead to portal hypertension or cirrhosis, is a wound-healing response to chronic liver injuries due to a variety of insults. The altered balance between the synthesis and degradation of matrix proteins (mainly collagens) is the major pathogenic feature in the hepatic fibrosis process. Although remarkable progress has been made recently in understanding the mechanisms of hepatic fibrosis and while numerous agents have been studied, very few effective antifibrogenic drugs have been approved for use in humans.

Previous research has showed that Cpd 861, which was formulated by one the authors (Dr. Bao-En Wang) in accordance with traditional Chinese medical theory, can significantly improve the clinical manifestations and biochemical parameters of patients with hepatic fibrosis. Their recent work found that the antifibrotic function of Cpd 861 is mediated not only by inhibiting collagen synthesis (by downregulating collagen type III gene expression) but also by enhancing the degradation of collagens (by increasing the expression of matrix metalloproteinase-1, which is an enzyme that degrades collagens). These effects are different from those of Western antifibrogenic drugs (such as interferon- gamma).

The authors explain that the herbs used to prepare Cpd 861 have been used for thousands of years in Traditional Chinese Medicine, and the results of this research could allow for the development of effective antifibrogenic drugs from Chi
'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
2. Scientists discover a mechanism that can send cells on the road to cancer
3. Mosquito mating mechanism could lead to new attack on dengue and yellow fever
4. Researchers Define Mechanism of Methamphetamine Addiction
5. Study identifies mechanism underlying multidrug resistance in fungi
6. Increased hepcidin expression: A novel oncogenic signalling mechanism
7. Researchers describe mechanisms by which capon gene causes heart rhythm disturbances
8. Novel mechanism found that may boost impaired function of leukemia protein
9. Mechanism of blood clot elasticity revealed in high definition
10. Who found some new mechanisms of HBV virulence?
11. Japan Backs Away from Making Real Changes to Its Rx Pharma Pricing Mechanism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... August 29, 2015 , ... Rio Salado College joined ... student experience as part of the EDUCAUSE - Next Generation Learning Challenges 2015 Breakthrough ... is the third Breakthrough Models Incubator hosted by EDUCAUSE and NGLC, which ...
(Date:8/28/2015)... , ... August 28, 2015 , ... The Kentucky State ... are qualified for the position they are applying for, they are unable to pass ... employers are considering altering drug testing policies in order to be able to hire ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... and Best Practices for Compliance, **Presented by FDAnews and GessNet**, Oct. 14-15, ... internationally renowned expert Fubin Wu, has been specifically designed to provide devicemakers ...
(Date:8/28/2015)... , ... August 28, 2015 , ... ... or those who might personally be struggling with chemical dependency, may be able ... Best Drug Rehabilitation, a results-driven holistic treatment center for addiction located in Western ...
(Date:8/28/2015)... , ... August 28, 2015 , ... ... nationwide. Addictions specialist, Dr. James Strawbridge, gives a new approach on solutions in ... should begin with the employer and employees getting together for meaningful group meetings. ...
Breaking Medicine News(10 mins):Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 3Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 4Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 2Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 3Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 4Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 2Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 4Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 5Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 2Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 3
... , , NATIONAL CANCER ... FREMONT, Calif. , Jan. 14 As a ... the Cancer Information Service (CIS) Partnership Program throughout the ... Northern California Cancer Center (NCCC) will no longer coordinate the ...
... , , FRESNO, Calif. , Jan. 14 ... field, the coach yells for a substitution. Yet, when fun celebrations for ... some of the most caloric and nutrient-poor snacks around. Renowned healthy chef ... registered dietitians Keri Glassman author of "The O Diet" and ...
... directly to trauma center, study finds , THURSDAY, Jan. 14 ... spines of trauma patients, to avoid a broken neck or ... the likelihood that gunshot and stabbing victims will die if ... The researchers, who report their findings in the January issue ...
... 14 Thirteen Detroit -area residents were arrested today ... Office of the Inspector General (HHS-OIG) and FBI in connection with ... of more than $14.5 million , announced Assistant Attorney General ... Barbara L. McQuade of the Eastern District of ...
... , MINNEAPOLIS and ST. ... Clinics of Minnesota is launching a major new initiative ... and St. Paul Hospitals.  This Arts and Healing initiative will ... a healing environment for patients and families at Children,s.  The program ...
... CORONADO, Calif. The American Association for Cancer Research and ... honored Paul A. Bunn Jr., M.D., for his leadership in ... Cancer conference this week. The conference, held from Jan. 11-14, ... Bunn is professor of medicine and the James Dudley chair ...
Cached Medicine News:Health News:Statewide Outreach & Information Service Program Operated by Northern California Cancer Center to End 2Health News:Statewide Outreach & Information Service Program Operated by Northern California Cancer Center to End 3Health News:Big Game Snacking Equals Super Diet Slacking 2Health News:Big Game Snacking Equals Super Diet Slacking 3Health News:Stabilizing Spine May Be Waste of Time in Gun, Knife Victims 2Health News:Thirteen Detroit-Area Individuals Arrested and Charged for $14.5 Million Medicare Fraud 2Health News:Thirteen Detroit-Area Individuals Arrested and Charged for $14.5 Million Medicare Fraud 3Health News:Thirteen Detroit-Area Individuals Arrested and Charged for $14.5 Million Medicare Fraud 4Health News:Children's Hospitals and Clinics of Minnesota Calls on Local Artists for New Arts and Healing Initiative 2Health News:Children's Hospitals and Clinics of Minnesota Calls on Local Artists for New Arts and Healing Initiative 3Health News:Lung cancer conference leaders honor Paul A. Bunn Jr., M.D. 2
(Date:8/28/2015)... 2015 Research and ... of the "Investigation Report on China,s Quetiapine ... Developed by AstraZeneca plc, quetiapine (under the ... for the treatment of schizophrenia. Approved by CFDA ... in the Catalogue of Drugs for the Basic ...
(Date:8/28/2015)... Research and Markets ... the "Investigation Report on China,s Latanoprost Market, ... Developed by Pharmacia & Upjohn in 1995, latanoprost ... reduces intraocular pressure. As the first pressure- lowering ... name of Xalatan) entered China ...
(Date:8/28/2015)... KONG , August 28, 2015 ... in collaboration with one of the leading academics in ... (current world record holder in life extension for model ... insights into biology of aging and age-related diseases, primarily, around ... The work has just been published as "Stability analysis of ...
Breaking Medicine Technology:China Quetiapine Market Investigation Report 2010-2019 2China Latanoprost Market Investigation Report 2015-2019 2Gero: Physics Meets Biology to Help Defeat Aging 2Gero: Physics Meets Biology to Help Defeat Aging 3
... Porous Technologies, a developer and manufacturer of custom fluid-handling ... introduce a new range of hydrophilic, polyurethane foams for ... trade fair in Dusseldorf, Germany from 16 to 18 ... New innovations to be featured at the ...
... Texas, Nov. 2, 2011 Novation commends the White ... facing America,s hospitals through its October 31st Executive Order. ... support of the bipartisan legislation – (S. 296 and ... to establish a framework by which the quality and ...
Cached Medicine Technology:Filtrona Porous Technologies to Introduce New Hydrophilic Foam Products for Advanced Wound Care at the MEDICA / COMPAMED Trade Fair 2
... belongs to the Flavavirus group pf viruses. ... tropics.,Symptoms of Dengue fever are the sudden ... back and limbs, lymphadenopathy,maculopapular rash and retrobulbar ... as an aid in the diagnosis of ...
A rapid immunochromatographic strip assay for the qualitative detection of antibodies to Visceral Leishmania in serum...
... test device is intended for ... IgG and IgM antibodies to ... The test is used as ... of Dengue viral infection and ...
... test is a qualitative one step ... conation of monoclonal,antibody/colloidal gold dye conjugate ... the solid phase. This will selectively ... (typhoid) infection with a high degree ...
Medicine Products: