Navigation Links
New finding may help explain development of preeclampsia
Date:2/8/2008

WINSTON-SALEM, N.C. In a study of pregnant women, those with pregnancy-induced high blood pressure were found to have higher levels of a peptide that raises blood pressure in the pieces of tissue linking mother and fetus, according to researchers at Wake Forest University Baptist Medical Center. The finding, reported online in the journal Hypertension, may help explain how the disorder develops.

Preeclampsia, or high blood pressure induced by pregnancy, affects 7 to 10 percent of pregnancies in the United States and is the second-leading cause of maternal mortality. It is the leading cause of pre-term delivery and contributes significantly to stillbirths and death in newborns.

The researchers found that in women with preeclampsia, levels of angiotensin II (Ang II), a hormone that constricts blood vessels and causes blood pressure to rise, was doubled in the chorionic villi, part of the placenta that links mother and fetus and supplies food and oxygen.

This finding may be part of the preeclampsia puzzle, said Lauren Anton, a graduate student who is first author on the research. Anything that gets us closer to understanding this disease is important because there is no treatment and no cure and women are still delivering babies too early.

The researchers theorize that Ang II may restrict the fetal vessels that lie within the chorionic villi, which not only raises blood pressure, but also lowers oxygen and nutrient flow to the baby and may result in lower birth weight and other complications of preeclampsia.

The study involved 21 women with preeclampsia and 25 women without the disorder. After delivery, tissue sections were taken from the center of the placenta for analysis.

Ang II is part of the renin angiotensin system (RAS) that regulates blood pressure. The system has been shown to play an important role in preeclampsia. However, changes in the system also occur in women who dont develop the condition. In normal pregnancies, estrogen causes increased levels of several hormones, including Ang II, in the blood. Despite the increase of Ang II in the blood during pregnancy, most women do not develop preeclampsia.

This the first study to demonstrate that all three peptides involved in the RAS are found in the chorionic villi of both normal and preeclamptic women. And, it was the first to show that levels of Ang II are higher in the chorionic villi of women with preeclampsia.

This implies that local tissues are contributing to the problem, said K. Bridget Brosnihan, Ph.D., senior researcher, who has been studying preeclampsia for 12 years. The hormone is remarkably elevated in this relatively small tissue, which implies that it has an important role in the development of preeclampsia.

The researchers hope that the findings may one day lead to treatment for preeclampsia.

ACE inhibitor drugs are currently used to lower Ang II in non-pregnant women with hypertension, but these drugs cannot be given to pregnant women. The study authors suggest that other therapies aimed at regulating blood pressure might be beneficial if they target the chorionic villi rather than the system as a whole. They are currently working to determine if growth factors that cause the placentas blood supply to develop may also be regulated by the increase in Ang II.


'/>"/>

Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. MarketResearch.com Distributes Key Findings on Global Specialty Medical Beds and Therapeutic Surfaces Market
2. New findings show Enbrel significantly reduced levels of C-reactive protein
3. Finding the Right Home for Your Vitamins and Other Supplements
4. Super Bowl Fans Should Heed Heart Risk Finding
5. New nanotube findings by Stanford researchers give boost to potential biomedical applications
6. NASA Releases Findings of Astronaut Survey
7. Findings point to molecular Achilles heel for half of breast cancer tumors
8. Researchers challenge previous findings regarding widely used asthma treatment
9. Statement From the Consumer Healthcare Products Association on the SAMHSA Findings on Cough Medicine Abuse
10. The blood-brain barrier: A misunderstood key to finding life-saving cures to brain disease
11. Finding the right words: Provider-patient discussions can help domestic violence victims speak up
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/13/2017)... ... ... KOAMTAC ®, Inc., a leading manufacturer of Bluetooth barcode scanners and mobile ... collector at the National Retail Federation’s Big Show (NRF17) held January 15-17 in New ... need for more compact and rugged devices for collecting barcode data paired with a ...
(Date:1/13/2017)... ... ... Pahrump, Nev., used an unsavory medical experience to think of a way to improve the ... for a half year due to lazy bladder," he said. "Keeping these things on my ... to do this." , He then designed and created a prototype of the FOLEY CRADLE, ...
(Date:1/13/2017)... ... 2017 , ... People who have sensitive teeth are about as common as ... teeth. Sadly, most dental hygiene products in the market contain chemical ingredients that only ... continuing their daily oral care routine to keep their teeth white and healthy is ...
(Date:1/13/2017)... ... January 13, 2017 , ... Friday, January 13 at 5 ... game room, increasing the size of the location to 90,000 square feet. , Included ... golf course that takes customers on an educational tour of the historic route, with ...
(Date:1/13/2017)... Tennessee (PRWEB) , ... January 13, 2017 , ... MyGenetx, ... Director of Communications, and Sales Administration Specialist, Mary Taylor Smith, RD, LD, will serve ... President after serving one year as a board member and one year as Vice ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... Pharmaceuticals, Inc. ("InMed") (CSE: IN; OTCQB: IMLFF), today announced that ... Banking at Eli Lilly & Company, has been appointed to ... 28 years of senior financial and executive leadership to InMed,s ... ... significant leadership position in financial and business expertise with one ...
(Date:1/13/2017)... , January 13, 2017 Stock-Callers ... Wright Medical Group N.V. (NASDAQ: WMGI ), Varian ... Inc. (NASDAQ: MDXG ), and NuVasive Inc. (NASDAQ: ... sector which fell back to a negative finish on Thursday, ... Index falling about 0.1%, while shares of health care companies ...
(Date:1/13/2017)... January 13, 2017 According ... and Equipment Market by Method (Biochemical (Calcium Phosphate, ... Protein Production), End User - Global Forecast to ... global market from 2016 to 2021. This market ... 2021 from USD 715.4 Million in 2016, at ...
Breaking Medicine Technology: