Navigation Links
New explanation for cardiac arrest
Date:4/19/2010

Researchers have discovered a new disorder linked to heart problems that stems from a genetic defect in the protein glycogenin. In a worst case scenario, disruption of this protein's function can lead to cardiac arrest, which is exactly what happened to the young man whose case triggered the investigation at Sahlgrenska University Hospital at the University of Gothenburg, Sweden, that led to a brand new diagnosis.

Published today in the revered New England Journal of Medicine, the study details how a young man suffered a cardiac arrest but survived thanks to the work of the ambulance paramedics. An investigation at Sahlgrenska University Hospital led to the discovery of not only a new disorder but also how a defect in the protein glycogenin can lead to an energy crisis in the muscle cells.

This protein's job is to initiate the build-up of glycogen that constitutes the muscle cells' carbohydrate reserves. The glycogenin starts the actual process by building up a short chain of around ten sugar molecules, which can then be turned into glycogen with the help of other enzymes. During strong muscular work the sugar molecules in the glycogen are used to create energy.

"The disorder is characterised by an inability to form the initial chain of sugar molecules," says Anders Oldfors, who headed up the research team and is a professor at the Sahlgrenska Academy and consultant at Sahlgrenska University Hospital. "This leads to a shortage of glycogen and an energy crisis in the muscle cells that can result in cardiac arrest."

The study also reveals how muscle cells that have a severe congenital defect can adjust and find other ways of sourcing energy, though it may not be sufficient in all situations.

"We're hoping that our continued research in the field will provide answers to how the change in the glycogenin causes an inability to start accumulating carbohydrates in the muscle cells," says Oldfors.

Clinically,
'/>"/>

Contact: Anders Oldfors
anders.oldfors@gu.se
46-313-422-084
University of Gothenburg
Source:Eurekalert

Page: 1 2

Related medicine news :

1. King Tuts Demise Gets New Explanation
2. His or hers jealousy? Study offers new explanation for sex differences in jealousy
3. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
4. "Zerona" Lipo-Laser Penetrates Wellness Industry for Anti-aging, Weight Loss, Body Sculpting and Cardiac Health
5. The creative engagement and cardiac health connection disclosed
6. Study from CWRU Nursing School finds a year after cardiac event only 37 percent still exercising
7. Minnesota State High School League and Take Heart Minnesota Team Up to Save More Lives From Sudden Cardiac Arrest (SCA)
8. As girth grows, risk of sudden cardiac death shrinks
9. Top 10 Pharmaceutical Company Awards Comprehensive Cardiac Safety Study to iCardiac
10. Doctors Turning to Cardiac Catheterization Too Quickly
11. Cardiac Science Sets Date for Fourth Quarter, Year-End Results Release and Conference Call
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... August 03, 2015 , ... ... research organisations (CROs) for a slew of benefits, allowing them to gain access ... boost quality with cost-effective utilisation of resources, get access to innovation and ensure ...
(Date:8/3/2015)... CA (PRWEB) , ... August 03, 2015 , ... ... services to help patients in need. Most people know that general health emergencies, such ... Unfortunately, a fewer amount of people know where to turn to during a dental ...
(Date:8/3/2015)... ... August 03, 2015 , ... AxoGen, Inc. (NASDAQ: AXGN), ... scheduled to present at the Wedbush Healthcare Conference on Wednesday, August 12, 2015 at ... and subsequent archived replay of the Company’s presentation may be accessed via the investor ...
(Date:8/3/2015)... ... 2015 , ... A July 13 article from The Daily Mail titled ... Painkiller That Can Last 'For Five Weeks'" discusses the use of stem cells ... showed that harvesting stem cell-rich bone marrow from the hip, known as bone marrow ...
(Date:8/3/2015)... ... 2015 , ... Constantin Vasilica, 48 from Romania wanted to have an alternative ... many years of suffering and using medications with strong side effects. This had already ... extra time off or wait longer hours in the waiting rooms. Instead, he went ...
Breaking Medicine News(10 mins):Health News:Global CRO Market Space Reviewed by Aniruddha Sowale in In-demand Research Report Available at MarketPublishers.com 2Health News:Global CRO Market Space Reviewed by Aniruddha Sowale in In-demand Research Report Available at MarketPublishers.com 3Health News:Los Angeles Dental Practice, Sunset Plaza Dental, Now Offers Emergency Dental Services 2Health News:Los Angeles Dental Practice, Sunset Plaza Dental, Now Offers Emergency Dental Services 3Health News:AxoGen, Inc. to Present at the Wedbush Healthcare Conference 2Health News:Los Angeles Spine Surgeon Gives Insight into How Stem Cells Can Relieve Back Pain 2Health News:Los Angeles Spine Surgeon Gives Insight into How Stem Cells Can Relieve Back Pain 3Health News:Chinese Health Care Provider Heshoutang Now Give Patients Complimentary Online Healing Options 2Health News:Chinese Health Care Provider Heshoutang Now Give Patients Complimentary Online Healing Options 3
... at Moffitt Cancer Center in Tampa, Fla., have found ... patients with gastrointestinal malignancies to higher body mass index ... negative outcomes, there was no such link. They concluded ... or esophageal cancer patient survival. Their study was ...
... News) -- The common cold appears to increase the ... them more sensitive, which triggers coughing, wheezing and breathlessness, ... especially vulnerable to this virus-induced coughing, said the researchers ... known as transient receptor potential (TRP) receptors. ...
... boys rated reading more valuable as an activity after ... new study. The findings come from a study ... and who participated in a reading improvement class that ... authors, Dara Williams-Rossi, Southern Methodist University, Dallas. The ...
... What happens on the day before a colonoscopy may ... Gastroenterologists at Washington University School of Medicine in ... prep for the test by cleansing their colons, doctors ... in the journal Gastrointestinal Endoscopy , the researchers ...
... Steven Reinberg HealthDay Reporter , MONDAY, March ... a novel "monoclonal antibody" lowered LDL cholesterol levels in ... percent. This new treatment could help lower levels ... who don,t respond to the commonly prescribed cholesterol-lowering drugs ...
... By Steven Reinberg HealthDay Reporter , MONDAY, March 26 ... with chest pain aren,t having a heart attack, but it can ... a new study finds that a special kind of CT scan ... faster than traditional methods, so patients can be sent home safely ...
Cached Medicine News:Health News:Does BMI affect post-surgical complications, survival in esophageal adenocarcinoma? 2Health News:Research Shows How Colds Lead to Coughing, Wheezing 2Health News:Middle school boys who are reluctant readers value reading more after using e-readers 2Health News:Middle school boys who are reluctant readers value reading more after using e-readers 3Health News:Poor colonoscopy prep hides pre-cancerous polyps 2Health News:Poor colonoscopy prep hides pre-cancerous polyps 3Health News:Poor colonoscopy prep hides pre-cancerous polyps 4Health News:New Injection Might Lower Tough-to-Treat Cholesterol 2Health News:New Injection Might Lower Tough-to-Treat Cholesterol 3Health News:CT Scans Can Spot Heart Trouble Fast 2Health News:CT Scans Can Spot Heart Trouble Fast 3
(Date:8/3/2015)... and FLORHAM PARK, N.J. , ... once-daily naldemedine met its primary and secondary endpoints in ... of opioid-induced constipation (OIC) in adult patients with chronic ... mu-opioid receptor antagonist (PAMORA). This is the third Phase ... key secondary endpoints. Study results showed that ...
(Date:8/3/2015)... BOULDER, Colo., Aug. 3, 2015  Encision Inc. (PK:ECIA), ... prevents dangerous stray electrosurgical burns in minimally invasive surgery, ... quarter that ended June 30, 2015. The ... a quarterly net loss of $213 thousand, or $(0.02) ... $2.476 million for a net loss of $202 thousand, ...
(Date:8/3/2015)... DIEGO , Aug. 3, 2015  Sorrento Therapeutics, ... it has entered into an exclusive licensing agreement to ... biobetter antibodies from Mabtech Limited, a holding company for ... China . Under the terms ... 4 monoclonal antibodies (mAbs) for the North American, European ...
Breaking Medicine Technology:Naldemedine Meets Primary Endpoint In Phase 3 Study For The Treatment Of Opioid-Induced Constipation 2Naldemedine Meets Primary Endpoint In Phase 3 Study For The Treatment Of Opioid-Induced Constipation 3Naldemedine Meets Primary Endpoint In Phase 3 Study For The Treatment Of Opioid-Induced Constipation 4Encision Reports First Quarter Fiscal Year 2016 Results 2Encision Reports First Quarter Fiscal Year 2016 Results 3Encision Reports First Quarter Fiscal Year 2016 Results 4Encision Reports First Quarter Fiscal Year 2016 Results 5Sorrento In-Licenses Four Late-Stage Clinical Biobetter and Biosimilar Antibodies 2Sorrento In-Licenses Four Late-Stage Clinical Biobetter and Biosimilar Antibodies 3Sorrento In-Licenses Four Late-Stage Clinical Biobetter and Biosimilar Antibodies 4
... spine can happen for any number of reasons, whether it,s ... old age, or blunt injury. Unfortunately, people who have experienced ... back braces, reduced mobility, and elongated periods of pain and ... patients are able to restore proper function to the spine ...
... 17, 2011 Zen Holding Corp. (Symbol: ZNHL) today ... name change to Millennium HealthCare Inc.  The Company will ... change as well. About Zen Holding Corp. ... company that operates thru its wholly-owned subsidiaries Greenleaf Management ...
Cached Medicine Technology:Dr. Seyed M. Rezaian's Spinal Fixator a Revolutionary Invention for Healing Injuries of the Thoracolumbar Spine 2Zen Holding Corp. Changes Name to Millennium HealthCare Inc. 2
3 Gently Curved Prongs, 5mm extended, Stainless Steel Tips; with titanium handle....
Straight shafts with fine Pierse type tips on a 5mm platform; In Titanium...
Straight shaft; a 5mm platform with 0.3mm 1x2 teeth; In Titanium....
Straight Shafts with 0.2mm 1X2 Teeth, 5mm Tying Platform; In Titanium....
Medicine Products: