Navigation Links
New evidence that smokeless tobacco damages DNA and key enzymes
Date:6/16/2010

Far from having adverse effects limited to the mouth, smokeless tobacco affects the normal function of a key family of enzymes found in almost every organ in the body, according to the first report on the topic in ACS' monthly journal Chemical Research in Toxicology. The enzymes play important roles in production of hormones, including the sex hormones estrogen and testosterone; production of cholesterol and vitamin D; and help the body breakdown prescription drugs and potentially toxic substances. Smokeless tobacco also damages genetic material in the liver, kidney and lungs.

Krishan Khanduja and colleagues note widespread recognition of smokeless tobacco's harmful effects on the mouth, which include an increased risk of gum disease and oral cancer. The potential carcinogens and other chemicals in chewing tobacco and other smokeless products are absorbed into the blood and travel throughout the body. However, scientists have little information on smokeless tobacco's effects on other parts of the body. To fill that knowledge gap, the scientists evaluated changes in enzymes and genetic material in laboratory rats using extracts of smokeless tobacco.

In addition to damage to the genetic material DNA, they found that smokeless tobacco extracts alter the function of the so-called CYP-450 family of enzymes. "These products are used around the world but are most common in Northern Africa, Southeast Asia, and the Mediterranean region," the report says. "Most of the users seem to be unaware of the harmful health effects and, therefore, use smokeless tobacco to 'treat' toothaches, headaches, and stomachaches. This false impression only promotes tobacco use among youth. The use of smokeless tobacco and its new products is increasing not only among men but also among children, teenagers, women, and immigrants of South Asian origin and medical and dental students."


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert  

Page: 1

Related medicine news :

1. Aleres Dr. Michael Taitel Presents Compelling Evidence at IBI/NBCH Health & Productivity Forum that Wellness Programs Positively Impact Health & Productivity
2. New Scientific Studies Show Further Evidence of Avandia Dangers
3. More Evidence That Statins Cut Stroke Risk
4. Wiley-Blackwell launches new online medical reference tool -- Essential Evidence
5. Mayo Clinic Proceedings: Researchers find evidence of survival gains in bone marrow disease
6. Considering the evidence in health care
7. EBSCO Publishing and Zynx Health Expand Partnership for Integrated Access to Evidence-Based Content
8. Hayes Announces Appointment Of Dr Susan Levine To The Medicare Evidence Development and Coverage Advisory Committee (MEDCAC)
9. Evidence-based care and outcomes improve at Get With The Guidelines-Stroke hospitals
10. Researchers find further evidence linking Epstein-Barr virus and risk of multiple sclerosis
11. More Evidence That Swings in Blood Pressure Raise Stroke Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New evidence that smokeless tobacco damages DNA and key enzymes
(Date:8/27/2014)... August 27, 2014 Skirt Sports , ... its partnership with pioneer runner, Kathrine Switzer, most noted for ... The collaboration creates a line of women’s running clothes that ... message of Kathrine’s 261 Fearless Movement. , “It ... icon,” said Nicole DeBoom. “Kathrine is the original Skirt ...
(Date:8/27/2014)... 2014 New Jersey’s own Morgan Hoffmann ... County Club during The Barclays – and thanks to ... the tournament’s four rounds, stepped his way into raising ... Blue Shield of New Jersey (Horizon BCBNSNJ) Walking Challenge. ... native playing before family and friends at the Paramus ...
(Date:8/27/2014)... Dennis Thompson HealthDay ... Someone who has been mugged in a dark alley will ... with a fear of being attacked. But neuroscientists working ... how memories are linked with positive and negative emotions. And ... emotions attached to a memory. In essence, they made ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Ticket Down ... Chile tickets at Levi’s Stadium in Santa Clara. ... Santa Clara, California just opened in July and will host ... Mexico takes on Chile. These are two of the best ... 2014 World Cup and will look to continue their successes ...
(Date:8/27/2014)... lipids are known to play a key role in ... like atherosclerosis. A new study at UCLA demonstrates that ... lung disease that narrows the small blood vessels in ... showed that a peptide mimicking part of the main ... may help reduce the production of oxidized lipids in ...
Breaking Medicine News(10 mins):Health News:Skirt Sports Launches Clothing Line with Legendary Runner Kathrine Switzer 2Health News:Morgan Hoffmann, PGA TOUR Pro & Wyckoff Native, golfs and walks his way to top 10 finish at The Barclays while raising additional $7,500 for charity 2Health News:Scientists 'Rewrite' Bad Memories in Mice 2Health News:Scientists 'Rewrite' Bad Memories in Mice 3Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 2Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 3Health News:Protein in 'good cholesterol' may be a key to treating pulmonary hypertension 2
... Md., Jan. 7 Hanger Orthopedic Group, Inc. (NYSE: ... its results of operations for the year ended December 31, ... a press release announcing the results for the year ended ... close of the market. The conference call is scheduled to ...
... identified mutations in a gene that predict a high ... (ALL). Although the researchers caution that further research is ... IKZF1 or IKAROS, lead to leukemia relapse, the findings ... tests to assess the risk of treatment failure. ...
... to Provide Support and Convenience CARLSBAD, Calif., Jan. ... of a new on-line service for physicians and ... and products. The new Web site, www.skinmedica.com ... physicians while offering the convenience of on-line information ...
... Seabrook House, an internationally recognized inpatient treatment center, is ... programs in 2009. The following is just a few ... that recovery from addiction is possible and that treatment works. ... family who needs it and to educate the public at ...
... (NYSE: MED ), a leading portion-controlled weight-loss program, ... Baltimore SmartCEO magazine. Medifast is a 2007 and ... the 50 fastest growing companies in the Greater Baltimore area ... 16, 2008 that The Company expects revenues in excess of ...
... Colo., Jan. 7 Zuma,s Rescue Ranch received its ... years of being self funded, Zuma,s Rescue Ranch can ... had a very busy 2008, along with formally becoming ... Health Institute on getting Medicaid to cover Equine Assisted ...
Cached Medicine News:Health News:Hanger Orthopedic Group, Inc. Announces 2008 Year-End Earnings Release Conference Call 2Health News:Gene abnormality found to predict childhood leukemia relapse 2Health News:Gene abnormality found to predict childhood leukemia relapse 3Health News:Gene abnormality found to predict childhood leukemia relapse 4Health News:SkinMedica Launches On-Line Service for Physician Partners 2Health News:Seabrook House Embraces the New Year with New Programs 2Health News:Seabrook House Embraces the New Year with New Programs 3Health News:Medifast Named Baltimore SmartCEO Future 50 Company for Second Time 2
(Date:8/27/2014)... Mass. , Aug. 27, 2014 North American ... a prestigious R&D 100 Award for the new OSRAM ITOS ... and LED-based white light module for microscopy, endoscopy and surgical ... lamps with significantly higher efficacy and lamp life. ... as one of the most innovative new technologies of the ...
(Date:8/27/2014)... STATESVILLE, N.C. , Aug. 27, 2014 ... today its Board of Directors increased its quarterly cash ... from eleven cents per outstanding share, beginning with the ... record at the close of business on September 8, ... Founded in 1906, Kewaunee Scientific Corporation is ...
(Date:8/27/2014)... , Aug. 27, 2014  Columbia Laboratories, Inc. (Nasdaq: ... provider of pharmaceutical development, clinical trial manufacturing, and advanced ... announced that it will participate at the upcoming Rodman ... to be held in New York ... 11:15am on September 9, 2014 at the New York ...
Breaking Medicine Technology:OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 2OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 3
... Expandable, Multichannel Pipettor The Equalizer ... productivity with an industry breakthroughequal tip spacings ... a slide rod. This innovation allows the ... vessels with different configurations. Adjustable and ...
... Ergonomic Design for Unparalleled Comfort Pick ... Notice the balance. Notice the trigger and ejector ... Thats because our pipettors are ergonomically designed to ... hours of pipetting. Productivity In The Palm ...
... Design for Unparalleled Comfort Pick one of ... balance. Notice the trigger and ejector positionsright where ... our pipettors are ergonomically designed to help avoid ... pipetting. Productivity In The Palm Of Your ...
... Ergonomic Design for Unparalleled Comfort Pick ... Notice the balance. Notice the trigger and ejector ... Thats because our pipettors are ergonomically designed to ... hours of pipetting. Productivity In The Palm ...
Medicine Products: