Navigation Links
New evidence that smokeless tobacco damages DNA and key enzymes
Date:6/16/2010

Far from having adverse effects limited to the mouth, smokeless tobacco affects the normal function of a key family of enzymes found in almost every organ in the body, according to the first report on the topic in ACS' monthly journal Chemical Research in Toxicology. The enzymes play important roles in production of hormones, including the sex hormones estrogen and testosterone; production of cholesterol and vitamin D; and help the body breakdown prescription drugs and potentially toxic substances. Smokeless tobacco also damages genetic material in the liver, kidney and lungs.

Krishan Khanduja and colleagues note widespread recognition of smokeless tobacco's harmful effects on the mouth, which include an increased risk of gum disease and oral cancer. The potential carcinogens and other chemicals in chewing tobacco and other smokeless products are absorbed into the blood and travel throughout the body. However, scientists have little information on smokeless tobacco's effects on other parts of the body. To fill that knowledge gap, the scientists evaluated changes in enzymes and genetic material in laboratory rats using extracts of smokeless tobacco.

In addition to damage to the genetic material DNA, they found that smokeless tobacco extracts alter the function of the so-called CYP-450 family of enzymes. "These products are used around the world but are most common in Northern Africa, Southeast Asia, and the Mediterranean region," the report says. "Most of the users seem to be unaware of the harmful health effects and, therefore, use smokeless tobacco to 'treat' toothaches, headaches, and stomachaches. This false impression only promotes tobacco use among youth. The use of smokeless tobacco and its new products is increasing not only among men but also among children, teenagers, women, and immigrants of South Asian origin and medical and dental students."


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert  

Page: 1

Related medicine news :

1. Aleres Dr. Michael Taitel Presents Compelling Evidence at IBI/NBCH Health & Productivity Forum that Wellness Programs Positively Impact Health & Productivity
2. New Scientific Studies Show Further Evidence of Avandia Dangers
3. More Evidence That Statins Cut Stroke Risk
4. Wiley-Blackwell launches new online medical reference tool -- Essential Evidence
5. Mayo Clinic Proceedings: Researchers find evidence of survival gains in bone marrow disease
6. Considering the evidence in health care
7. EBSCO Publishing and Zynx Health Expand Partnership for Integrated Access to Evidence-Based Content
8. Hayes Announces Appointment Of Dr Susan Levine To The Medicare Evidence Development and Coverage Advisory Committee (MEDCAC)
9. Evidence-based care and outcomes improve at Get With The Guidelines-Stroke hospitals
10. Researchers find further evidence linking Epstein-Barr virus and risk of multiple sclerosis
11. More Evidence That Swings in Blood Pressure Raise Stroke Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New evidence that smokeless tobacco damages DNA and key enzymes
(Date:1/20/2017)... ... January 20, 2017 , ... “Mary Magdalene: Grace is ... life of the woman who witnessed Jesus Christ firsthand. “Mary Magdalene: Grace is Greater ... spent her career as an educator interacting with countless women who had little knowledge ...
(Date:1/20/2017)... ... 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following a man who went on ... of published author, Marlyn Ivey, born in Lynn Haven, Florida and at the age of ... 19 years of age, he joined the Navy and got married right out of boot ...
(Date:1/20/2017)... ... January 20, 2017 , ... D ... Expiratory Pressure (OPEP) device, was featured in a study indicating superior performance against ... FAARC, “Analysis of Three Oscillating Positive Expiratory Pressure Devices During Simulated Breathing“ ...
(Date:1/20/2017)... ... ... and enchanting tale that teaches children the true meaning of Christmas. “Journey to Christmas” is ... a devoted woman of faith. , “Becoming a parent changes you. In my case, ... for years, but actually doing it might have been a while in coming if it ...
(Date:1/20/2017)... ... January 20, 2017 , ... “The Land of More ... to the issue of world hunger, and shares the simple and achievable answer. “The ... husband and member of the Fairview Missionary Church in Angola, Indiana where he works ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... NEW YORK , Jan. 19, 2017 /PRNewswire/ ... reach USD 233.7 billion by 2025, according to ... The market is anticipated to be predominantly driven ... companies, resulting into the large-scale production of new ... widen the influx of drugs at an unprecedented ...
(Date:1/19/2017)... The Global Therapy Partnering Terms and Agreements ... deals and agreements entered into by the world,s leading ... Top deals by value - Deals listed by company ... The report provides understanding and access to the partnering ... healthcare companies. The report provides an analysis of ...
(Date:1/19/2017)... and Webcast to Follow Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: ... the fourth quarter of 2016 on Wednesday, February 15, 2017, after ... ... on Wednesday, February 15, 2017, during which management will discuss the ... activities. To participate in the conference call, please dial 1-888-771-4371 (domestic) ...
Breaking Medicine Technology: