Navigation Links
New evidence that 'gout' strongly runs in the family
Date:12/2/2013

It's historically known as 'the king of diseases and the disease of kings' and was long thought to be caused by an overindulgent lifestyle, but now scientists at The University of Nottingham have confirmed that 'gout' strongly runs in families.

Researchers in the Division of Rheumatology, Orthopaedics and Dermatology studied the whole population of Taiwan (23 million) where gout is most prevalent in the world. The findings have just been published in the leading rheumatology journal, Annals of the Rheumatic Diseases.

By examining 4.2 million identifiable families, the scientists found compelling evidence that the disease clusters in families, with increased risks for people with first and second degree relatives suffering from gout.

Gout is a kind of inflammatory arthritis, with sudden onset of acute pain, redness and swelling in peripheral joints, most commonly the joint in the big toe. It is caused by the deposition of monosodium urate crystals, which is related to high uric acid in the blood. The resulting acute arthritis and lumps around the joint cause disability due to pain and loss of joint function.

There is also increasing evidence that gout is not only a disease of joints but also is associated with major cardiovascular (heart attack, stroke) and renal diseases (kidney failure).

Previous studies had suggested that gout often clusters within families, which is indirect evidence for a role of genetic factors in causation. However, one recent classic twin study paradoxically found strong heritability for high uric acid but no evidence for heritability in gout.

Lead researcher on the project, Dr Chang Fu Kuo, said: "Our results confirm the clinical belief that gout strongly clusters within families. In Taiwan the risk of an individual with any first-degree relative suffering from gout is approximately twice that of the normal population.

"The risk increases with the number of the first-degree relatives affected. Having a twin brother with gout carries an 8-fold risk, whereas having a parent or offspring with gout has a 2-fold risk. The study also demonstrates that in addition to the genetic risk, shared environment factors play a substantial role in the aetiology of gout. The influences of environmental and genetic factors on the risk of gout are different in men and women. Genetic factors contribute one-third in men and one-fifth in women."

Professor Michael Doherty, Head of the Academic Rheumatology added: "We found evidence for both shared environmental factors and genetic factors in predisposing to gout within families, with environmental factors contributing a higher proportional risk. Both genetic and environmental factors play a role in gout pathogenesis. Having an affected family member increases the risk but part of the risk comes from modifiable shared environmental factors such as diet and lifestyle."

The findings from this study open new questions for future research. In particular large-scale genetic profiling is needed to find susceptibility genes. Further epidemiology studies, including in other countries, to identify 'shared environmental factors' within families contributing to the risk of gout will be very helpful.


'/>"/>

Contact: Emma Rayner
emma.rayner@nottingham.ac.uk
44-011-595-15793
University of Nottingham
Source:Eurekalert

Related medicine news :

1. Researchers find evidence of banned antibiotics in poultry products
2. Report says new evidence could tip the balance in aspirin cancer prevention care
3. More Evidence Bilingualism Aids Thinking Skills
4. Novel biomarkers reveal evidence of radiation exposure
5. Antiretroviral treatment for preventing HIV infection: an evidence review for physicians
6. WSU study finds overwhelming evidence of hidden heart disease in hypertensive African-Americans
7. Study shows no evidence medical marijuana increases teen drug use
8. Study of Retired NFL Players Finds Evidence of Brain Damage
9. New evidence for link between obesity and circle of friends
10. Cochrane finds no reliable evidence on effectiveness of electric fans in heatwaves
11. Study Gives First Evidence That Adult Human Lungs Can Regrow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading ... Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly ... CBD form that can be easily incorporated into liquid products, while reducing costs to ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The Visiting Nurse ... Market. Featuring a collection of specialty vendors and unique items from across the nation, ... quality-focused health and wellness services offered by the VNA. The boutique will be ...
(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Planet Fitness, ... the U.S., announced today its plans to open a flagship location in Covington, LA ... the former Rooms To Go store next to Office Depot in the Holiday Square ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  True Health, a leader in integrated ... during National Breast Cancer Awareness month to educate ... Research recently published ... more than 10 million American women are at ... or BRCA2 and have not had testing. These mutations ...
(Date:10/5/2017)... Oct. 5, 2017  In response to the ... and Maxillofacial Surgeons (AAOMS) released prescribing recommendations that ... be used as a first-line therapy to manage ... Recognizing the value and ... Paper "Opioid Prescribing: Acute and Postoperative Pain Management" ...
(Date:10/2/2017)... 2, 2017  Eli Lilly and Company (NYSE: ... the third quarter of 2017 on Tuesday, October 24, ... that day with the investment community and media to ... conference call will begin at 9 a.m. Eastern time. ... live webcast of the conference call through a link ...
Breaking Medicine Technology: