Navigation Links
New electrically-conductive polymer nanoparticles can generate heat to kill colorectal cancer cells
Date:11/20/2012

WINSTON-SALEM, N.C., Nov. 20, 2012 Researchers at Wake Forest Baptist Medical Center have modified electrically-conductive polymers, commonly used in solar energy applications, to develop revolutionary polymer nanoparticles (PNs) for a medical application. When the nanoparticles are exposed to infrared light, they generate heat that can be used to kill colorectal cancer cells.

The study was directed by Assistant Professor of Plastic and Reconstructive Surgery, Nicole H. Levi-Polyachenko, Ph.D., and done in collaboration with colleagues at the Center for Nanotechnology and Molecular Materials at Wake Forest University. This study was recently published online, ahead of print, in the journal, Macromolecular Bioscience (DOI: 10.1002/mabi.201200241).

Levi-Polyachenko and her team discovered a novel formulation that gives the polymers two important capabilities for medical applications: the polymers can be made into nanoparticles that are easily dispersed in water and generate a lot of heat when exposed to infrared light.

Results of this study showed that when colorectal cancer cells incubated with the PNs were exposed to five minutes of infrared light, the treatment killed up to 95 percent of cells. "The results of this study demonstrate how new medical advancements are being developed from materials science research," said Levi-Polyachenko.

The team made polymer nanoparticles and showed that they could undergo repeated cycles of heating and cooling without affecting their heating ability. This offers advantages over metal nanoparticles, which can melt during photothermal treatments, leading to a loss of heating efficiency. This also allows for subsequent treatments to target cells that are resistant to heat-induced killing.

A challenge with other electrically-conductive polymers that have recently been explored for photothermal therapy is that these other polymers absorb across a wide range of infrared light. Christopher M. MacNeill, Ph.D., post-doctoral researcher at Wake Forest and first author on the paper, noted that, "we have specifically used electrically-conductive polymers designed to absorb a very narrow region of infrared light, and have also developed small, 50-65nm, polymer nanoparticles in order to optimize both biological transport as well as heat transfer." For example, 50nm is about 2000 times smaller than a human hair.

In addition, the new PNs are organic and did not show any evidence of toxicity, alleviating concerns about the effect of nanoparticles that may potentially linger in the body.

"There is a lot more research that needs to be done so that these new nanoparticles can be used safely in patients," Levi-Polyachenko cautioned, "but the field of electrically-conductive polymers is broad and offers many opportunities to develop safe, organic nanoparticles for generating heat locally in a tissue. We are very enthusiastic about future medical applications using these new nanoparticles, including an alternative approach for treating colorectal cancer."


'/>"/>

Contact: Paula Faria
pfaria@wakehealth.edu
336-716-1279
Wake Forest Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Singular polymer, multiple functions
2. Applied nanobiomedicine: Exploiting nanoparticles to hunt for hidden cancer cells
3. Nanoparticles engineered at Notre Dame promise to improve blood cancer treatment
4. Researchers find gold nanoparticles capable of unzipping DNA
5. New nanoparticles shrink tumors in mice
6. UCSB scientists examine effects of manufactured nanoparticles on soybean crops
7. Improved nanoparticles deliver drugs into brain
8. Nanoparticles detect biochemistry of inflammation
9. UGA researchers boost efficacy of drugs by using nanoparticles to target powerhouse of cells
10. New technique predictably generates complex, wavy shapes
11. Abnormal gene product associated with prostate cancer generated by unusual mechanism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2020)... FORT WORTH, Texas (PRWEB) , ... August 03, ... ... biopharmaceutical company, today announced enrollment of the first patients with first-line advanced pancreatic ... the ongoing phase 1/2 1801 trial of 9-ING-41, (NCT03678883, EudraCT#:2018-003739-32). 9-ING-41 is ...
(Date:7/31/2020)... SAN FRANCISCO (PRWEB) , ... July 31, 2020 ... ... for employers and health plans, is announcing an expansion of clinical & technical ... and health plans the most complete back and joint health solution. , ...
(Date:7/22/2020)... ... July 22, 2020 , ... As part of August’s Children’s Eye Health and Safety Month, and ... Eye Health at Prevent Blindness (NCCVEH) has released an updated version of the report ... . The goal of the report is , to provide ...
(Date:7/22/2020)... ... July 22, 2020 , ... ... of infectious diseases for patients and staff. These measures include partnering with ... prevention resources. This timely response is based on guidance from the Centers ...
(Date:7/18/2020)... ... July 17, 2020 , ... HMI Performance Incentives’ campaign, Spread ... was a charitable push put together to help spread positivity in the wake ... pandemic, HMI asked individuals in its audience to share stories, answering questions such ...
Breaking Medicine News(10 mins):
(Date:7/10/2020)... ... July 10, 2020 , ... Precision ADM, ... manufacturing solutions provider today announced that their CANSWAB™ nasopharyngeal swabs are the first ... engineered a new 3D-printed swab design and has trademarked the name CANSWAB™ for ...
(Date:7/10/2020)... ... July 10, 2020 , ... The Dolphin ... of experience and more than 12 million guests, unveiled its new comprehensive plan ... care and attention in all facets of the operation, safety, and health addressing ...
(Date:7/10/2020)... ... July 09, 2020 , ... The Urgent Care Association (UCA), College ... are collaborating to present a virtual education on acute flaccid myelitis (AFM), an uncommon ... at 1 p.m. CT on July 14, 2020. , AFM, which is most ...
Breaking Medicine Technology: