Navigation Links
New electrically-conductive polymer nanoparticles can generate heat to kill colorectal cancer cells

WINSTON-SALEM, N.C., Nov. 20, 2012 Researchers at Wake Forest Baptist Medical Center have modified electrically-conductive polymers, commonly used in solar energy applications, to develop revolutionary polymer nanoparticles (PNs) for a medical application. When the nanoparticles are exposed to infrared light, they generate heat that can be used to kill colorectal cancer cells.

The study was directed by Assistant Professor of Plastic and Reconstructive Surgery, Nicole H. Levi-Polyachenko, Ph.D., and done in collaboration with colleagues at the Center for Nanotechnology and Molecular Materials at Wake Forest University. This study was recently published online, ahead of print, in the journal, Macromolecular Bioscience (DOI: 10.1002/mabi.201200241).

Levi-Polyachenko and her team discovered a novel formulation that gives the polymers two important capabilities for medical applications: the polymers can be made into nanoparticles that are easily dispersed in water and generate a lot of heat when exposed to infrared light.

Results of this study showed that when colorectal cancer cells incubated with the PNs were exposed to five minutes of infrared light, the treatment killed up to 95 percent of cells. "The results of this study demonstrate how new medical advancements are being developed from materials science research," said Levi-Polyachenko.

The team made polymer nanoparticles and showed that they could undergo repeated cycles of heating and cooling without affecting their heating ability. This offers advantages over metal nanoparticles, which can melt during photothermal treatments, leading to a loss of heating efficiency. This also allows for subsequent treatments to target cells that are resistant to heat-induced killing.

A challenge with other electrically-conductive polymers that have recently been explored for photothermal therapy is that these other polymers absorb across a wide range of infrared light. Christopher M. MacNeill, Ph.D., post-doctoral researcher at Wake Forest and first author on the paper, noted that, "we have specifically used electrically-conductive polymers designed to absorb a very narrow region of infrared light, and have also developed small, 50-65nm, polymer nanoparticles in order to optimize both biological transport as well as heat transfer." For example, 50nm is about 2000 times smaller than a human hair.

In addition, the new PNs are organic and did not show any evidence of toxicity, alleviating concerns about the effect of nanoparticles that may potentially linger in the body.

"There is a lot more research that needs to be done so that these new nanoparticles can be used safely in patients," Levi-Polyachenko cautioned, "but the field of electrically-conductive polymers is broad and offers many opportunities to develop safe, organic nanoparticles for generating heat locally in a tissue. We are very enthusiastic about future medical applications using these new nanoparticles, including an alternative approach for treating colorectal cancer."


Contact: Paula Faria
Wake Forest Baptist Medical Center

Related medicine news :

1. Singular polymer, multiple functions
2. Applied nanobiomedicine: Exploiting nanoparticles to hunt for hidden cancer cells
3. Nanoparticles engineered at Notre Dame promise to improve blood cancer treatment
4. Researchers find gold nanoparticles capable of unzipping DNA
5. New nanoparticles shrink tumors in mice
6. UCSB scientists examine effects of manufactured nanoparticles on soybean crops
7. Improved nanoparticles deliver drugs into brain
8. Nanoparticles detect biochemistry of inflammation
9. UGA researchers boost efficacy of drugs by using nanoparticles to target powerhouse of cells
10. New technique predictably generates complex, wavy shapes
11. Abnormal gene product associated with prostate cancer generated by unusual mechanism
Post Your Comments:
(Date:11/27/2015)... ... 2015 , ... The moment you stop improving is the ... the needs of advisers and clients but going above and beyond to find ... service. However, there's always room for improvement, which is why the entire Consulting ...
(Date:11/27/2015)... ... 2015 , ... CBD College is proud to announce that on ... accreditation to its Diagnostic Medical Sonography program. CBD College is honored to join this ... colleges and universities in the state of California make the cut. CBD College is ...
(Date:11/27/2015)... ... 2015 , ... Dr. Thomas Dunlap and Dr. Patrick Coleman ... with Emergency Medicine at St., Joseph Health System’s Santa Rosa Memorial Hospital , ... in similar ways and require time-critical intervention to avoid large area heart damage and ...
(Date:11/27/2015)... ... ... Indosoft Inc., developer and distributor of the world-class Asterisk ... Term Support) into its Q-Suite 5.10 product line. , Making the change to ... of Asterisk that will receive not only security fixes, but feature and bug ...
(Date:11/26/2015)... ... 2015 , ... Inevitably when people think Thanksgiving, they also think Holiday sales ... Black Friday and Cyber Monday massage chair sales to receive the best ... low to find the best massage chair deals, they can see all of the ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 2015 AAIPharma Services Corp./Cambridge Major Laboratories, ... least $15.8  Million to expand its laboratories and ... . The expansion will provide additional office space ... demands of the pharmaceutical and biotechnology markets. ... provide up to 40,000 square feet of expanded ...
(Date:11/25/2015)... , Nov. 25, 2015  ARKRAY USA ... continues to provide evidence demonstrating the accuracy of its ... Congress on Insulin Resistance, Diabetes and Cardiovascular Disease in ... both the Company,s GLUCOCARD ® 01 meter and ... accuracy requirements. The ability to accurately measure glucose levels ...
(Date:11/25/2015)... 25, 2015 Kitov Pharma ... KTOV), a biopharmaceutical company focused on the development of ... conditions, today announced the closing of its previously announced ... ADSs ), each representing 20 ordinary shares of the ... The ADSs and warrants were issued in a fixed ...
Breaking Medicine Technology: