Navigation Links
New effort to battle antibiotic resistance rallies researchers throughout Harvard University

Boston. MA--The National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) have awarded $5 million to an interdisciplinary group of Harvard researchers to launch the "Harvard-wide Program on Antibiotic Resistance." Headed by Michael S. Gilmore, Ph.D., (Senior Scientist, Schepens Eye Research Institute and Schepens Professor of Ophthalmology [Department of Microbiology and Molecular Genetics], HMS), the group is uniting Harvard institutions in the fight against methicillin-resistant Staphylococcus aureus (MRSA) and other antibiotic resistant infection. The goal of the project is for the research team with a range of expertise to tackle the problem from different directions, and then to translate those findings into better treatments.

It shocked many a year and a half ago when CDC researchers noted that methicillin-resistant S. aureus (MRSA) were killing more in the US than HIV/AIDS (over 18,000 deaths per year). According to Gilmore, other penicillin resistant strains of S. aureus cause almost half again as many deaths. Worse, since 2002, MRSA have been acquiring resistance to one of the last line drugs used to treat those infections, vancomycin, a problem he has been studying with scientists at CDC.

MRSA are a major concern for hospitalized patients. More recently they have begun causing infections in healthy individuals in the community as well -- approximately 15% of invasive MRSA infections occur in patients with no known underlying cause. Most of these infections begin as skin infections, some acquired in sports locker rooms and other shared facilities. The infections become life-threatening when the microbe enters the bloodstream. New strains of MRSA have emerged that are causing many of the community infections.

Gilmore credits the Harvard-wide Microbial Sciences Initiative (an initiative launched in 2004 to bring together microbiology researchers from all Harvard campuses), the Harvard Catalyst Clinical and Translational Science Center, and a Schepens program to launch interdisciplinary research projects, for bringing this team together.

"We have been friends and collaborators on this important problem and also the new interdisciplinary and translational efforts on campus. Formalizing these relationships was a small and logical step that each of us embraced. We were lucky that all of the pieces fell into place so well," said Gilmore.

Working with molecular microbiologist Gilmore are: David Hooper, MD (Associate Chief of Infectious Diseases and Head of Infection Control, MGH and Professor of Medicine, HMS); Suzanne Walker, Ph.D. (Professor of Microbiology and Molecular Genetics, HMS); Eleftherios Mylonakis, MD, PhD (Assistant Professor of Medicine, HMS and Member, Infectious Diseases, MGH); and Frederick M. Ausubel, Ph.D., Professor of Genetics HMS, and Member, Molecular Biology, MGH).

Walker, Mylonakis and Ausubel will be taking different high-throughput approaches to screen libraries of compounds for possible new drugs. Gilmore, Hooper and Mylonakis will then test these compounds for their ability to clear an infection, and will also examine possible pathways for the development of resistance. These projects will additionally benefit from input from, Richard Losick, Ph.D. (Harvard College Professor and Maria Moors Cabot Professor of Biology), who will assist Gilmore on his subproject, as well as head an advisory panel.


Contact: Patti Jacobs
Schepens Eye Research Institute

Related medicine news :

1. Blue Cross and Blue Shield of Georgia Foundation Donates $25,000 to Red Cross for Flood Relief Efforts in Georgia
2. Kaiser Permanente Recognized by National Committee for Quality Assurance for Innovative Efforts to Reduce Health Care Disparities
3. Greenway Medical Technologies EHR Platform Continues to Lead Interoperability Efforts With Participation in Key Health IT Integration Showcases
4. Sudden Cardiac Arrest Association Honors Illinois Governor Pat Quinn for Legislative Efforts to Increase Survivability of Sudden Cardiac Arrest
5. Sudden Cardiac Arrest Association Honors FDNYs Department of Emergency Services for Efforts to Address Sudden Cardiac Arrest
6. Typhoon Parma: World Vision Launches Relief Efforts in the Philippines, Pre-positions Supplies in Taiwan
7. Cord Blood America Retires Note in Continuing Effort to Reduce Debt
8. The Kingdom of Saudi Arabia Commits $30 Million to Polio Eradication Efforts
9. Kidney advocates launch $10.25 million effort to examine cause of kidney failure
10. Childrens Hospitals and Clinics of Minnesota Launches H1N1 Outreach Effort with Minneapolis and Saint Paul Public Schools
11. NFL Network Launches 2009 National Keep Gym in School Campaign at New York City Middle School; Effort Will Give More U.S. Students Access to Quality Physical Education
Post Your Comments:
(Date:11/30/2015)... Ill. (PRWEB) , ... November 30, 2015 , ... ... Decision Support Solutions, announced at the Radiology Society of North America (RSNA) annual ... have seen over 60% growth from 2014. Throughout 2015, the company has ...
(Date:11/30/2015)... ... November 30, 2015 , ... Since its inception, Seniors Guide ... living, assisted living and all other retirement options. Support for issues surrounding the ... remains a top priority. , So it’s no surprise that every November, ...
(Date:11/30/2015)... Washington, DC (PRWEB) , ... ... ... Services, Inc. (AIS) is pleased to announce the speakers for “Value-Based Payer-Provider ... valuable lessons learned from three innovative value-based care arrangements: Essentia Health and ...
(Date:11/30/2015)... PA (PRWEB) , ... November 30, 2015 , ... ... software provider, has verified that their Vasont Universal Integrator (VUI) extension unites with ... creating, editing, and managing content as a continuous process with the latest release ...
(Date:11/30/2015)... ... 30, 2015 , ... Scott Newman MD, FACS of New ... plastic surgeons in the New York City area to utilize the new, non-invasive ... heat-induced laser treatment for fat loss in the abdomen, flanks, and other areas ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... and REHOVOT, Israel , Nov. 30, ... company focused on acquiring and developing innovative therapies for ... appointment of Keith A. Katkin as chairman ... J. Flesher , chief executive officer for OticPharma, Ltd.  ... organizations.  As chairman, he will be able to share ...
(Date:11/29/2015)... , Nov. 29, 2015  Strengthening its leadership ... PHG, AEX: PHIA) today announced IntelliSpace Portal 8.0 ... analytics and visualization platform that helps radiologists detect, diagnose ... 2015 Radiological Society of North America Annual Meeting ... IntelliSpace Portal 8.0 helps address the changing demands in ...
(Date:11/29/2015)... -- The GE Health Cloud 1 was unveiled today at ... North America (RSNA) meeting in Chicago ... cloud ecosystem and its applications will connect radiologists and clinicians ... teams – both inside and outside the hospital setting. ... "As the digital industrial leader, we are betting big on ...
Breaking Medicine Technology: