Navigation Links
New effort to battle antibiotic resistance rallies researchers throughout Harvard University
Date:10/13/2009

Boston. MA--The National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) have awarded $5 million to an interdisciplinary group of Harvard researchers to launch the "Harvard-wide Program on Antibiotic Resistance." Headed by Michael S. Gilmore, Ph.D., (Senior Scientist, Schepens Eye Research Institute and Schepens Professor of Ophthalmology [Department of Microbiology and Molecular Genetics], HMS), the group is uniting Harvard institutions in the fight against methicillin-resistant Staphylococcus aureus (MRSA) and other antibiotic resistant infection. The goal of the project is for the research team with a range of expertise to tackle the problem from different directions, and then to translate those findings into better treatments.

It shocked many a year and a half ago when CDC researchers noted that methicillin-resistant S. aureus (MRSA) were killing more in the US than HIV/AIDS (over 18,000 deaths per year). According to Gilmore, other penicillin resistant strains of S. aureus cause almost half again as many deaths. Worse, since 2002, MRSA have been acquiring resistance to one of the last line drugs used to treat those infections, vancomycin, a problem he has been studying with scientists at CDC.

MRSA are a major concern for hospitalized patients. More recently they have begun causing infections in healthy individuals in the community as well -- approximately 15% of invasive MRSA infections occur in patients with no known underlying cause. Most of these infections begin as skin infections, some acquired in sports locker rooms and other shared facilities. The infections become life-threatening when the microbe enters the bloodstream. New strains of MRSA have emerged that are causing many of the community infections.

Gilmore credits the Harvard-wide Microbial Sciences Initiative (an initiative launched in 2004 to bring together microbiology researchers from all Harvard campuses), the Harvard Catalyst Clinical and Translational Science Center, and a Schepens program to launch interdisciplinary research projects, for bringing this team together.

"We have been friends and collaborators on this important problem and also the new interdisciplinary and translational efforts on campus. Formalizing these relationships was a small and logical step that each of us embraced. We were lucky that all of the pieces fell into place so well," said Gilmore.

Working with molecular microbiologist Gilmore are: David Hooper, MD (Associate Chief of Infectious Diseases and Head of Infection Control, MGH and Professor of Medicine, HMS); Suzanne Walker, Ph.D. (Professor of Microbiology and Molecular Genetics, HMS); Eleftherios Mylonakis, MD, PhD (Assistant Professor of Medicine, HMS and Member, Infectious Diseases, MGH); and Frederick M. Ausubel, Ph.D., Professor of Genetics HMS, and Member, Molecular Biology, MGH).

Walker, Mylonakis and Ausubel will be taking different high-throughput approaches to screen libraries of compounds for possible new drugs. Gilmore, Hooper and Mylonakis will then test these compounds for their ability to clear an infection, and will also examine possible pathways for the development of resistance. These projects will additionally benefit from input from, Richard Losick, Ph.D. (Harvard College Professor and Maria Moors Cabot Professor of Biology), who will assist Gilmore on his subproject, as well as head an advisory panel.


'/>"/>

Contact: Patti Jacobs
pjacobs12@comcast.net
617-864-2712
Schepens Eye Research Institute
Source:Eurekalert

Related medicine news :

1. Blue Cross and Blue Shield of Georgia Foundation Donates $25,000 to Red Cross for Flood Relief Efforts in Georgia
2. Kaiser Permanente Recognized by National Committee for Quality Assurance for Innovative Efforts to Reduce Health Care Disparities
3. Greenway Medical Technologies EHR Platform Continues to Lead Interoperability Efforts With Participation in Key Health IT Integration Showcases
4. Sudden Cardiac Arrest Association Honors Illinois Governor Pat Quinn for Legislative Efforts to Increase Survivability of Sudden Cardiac Arrest
5. Sudden Cardiac Arrest Association Honors FDNYs Department of Emergency Services for Efforts to Address Sudden Cardiac Arrest
6. Typhoon Parma: World Vision Launches Relief Efforts in the Philippines, Pre-positions Supplies in Taiwan
7. Cord Blood America Retires Note in Continuing Effort to Reduce Debt
8. The Kingdom of Saudi Arabia Commits $30 Million to Polio Eradication Efforts
9. Kidney advocates launch $10.25 million effort to examine cause of kidney failure
10. Childrens Hospitals and Clinics of Minnesota Launches H1N1 Outreach Effort with Minneapolis and Saint Paul Public Schools
11. NFL Network Launches 2009 National Keep Gym in School Campaign at New York City Middle School; Effort Will Give More U.S. Students Access to Quality Physical Education
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... Cambridge, MA (PRWEB) , ... February 09, 2016 ... ... Institute (WCRI) compares the workers’ compensation fee schedule rates and Medicare rates for ... medical services covered in the report, Evaluation of the 2015 Fee Schedule ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... announces today the continuation of the ‘Pay It Forward’ program into 2016. BioPlus ... received at our specialty pharmacy. , “Since our Pay It Forward program ...
(Date:2/9/2016)... , ... February 10, 2016 , ... The Journal ... need to “level the playing field .” , As corresponding author Dr John F. ... use to categorize and diagnose our chronic pain patients. ‘Chronic cancer pain’ and ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... to expand access to affordable hearing aids , increase industry transparency, and ... in the United States. , “For the average consumer, the hearing aid industry ...
(Date:2/9/2016)... ... 2016 , ... Two renowned photographers, Robert Caplin (New York, NY) and Peter ... June 14-19, 2016, hosted by Four Seasons Resort Maui at Wailea as part of ... in 2015, the Maui Photo Expedition workshop will once again consist of ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... 2016 The leader in accelerated orthodontics, OrthoAccel ... is the recipient of the 2015 Townie Choice Award ... II medical device that speeds up orthodontic tooth movement ... often associated with treatment, AcceleDent was selected by orthodontists ... Orthotown survey of the most reliable and ...
(Date:2/9/2016)... NEW BRUNSWICK, N.J. , Feb. 9, 2016 /PRNewswire/ ... in the RBC Capital Markets Global Healthcare Conference on ... New York City.  Dominic Caruso , Vice President, ... , Worldwide Chairman, Consumer will represent the Company in ... www.investor.jnj.com . --> www.investor.jnj.com . ...
(Date:2/9/2016)... Md. , Feb. 9, 2016  The ... for pharmaceutical professionals developing and manufacturing sterile drug ... Sterile Manufacturing Regulatory Guidance Comparison – With link ... guidance documents issued by the U.S. FDA, the ... Health Organization. --> ...
Breaking Medicine Technology: