Navigation Links
New drugs to relieve cancer pain
Date:6/21/2010

Researchers at the University of Leicester and the University of Ferrara in Italy have collaborated to develop new drugs which have the potential to relieve cancer pain without causing many of the side effects of current pain-treatments like morphine.

Figures show that 90% of cancer patients experience pain in the final year of their lives and this is a big problem. Currently, the use of drugs like morphine produces side effects such as depressed breathing, drowsiness, constipation and tolerance. Unfortunately tolerance usually results in an increased dose of morphine, which in turn means that patients experience more of these side effects.

Professors David Lambert and David Rowbotham at the University of Leicester, as well as Doctors Guerrini, Calo and Professor Salvadori from the University of Ferrara in Italy, are leading the early experiments of a new group of drugs which may not produce these side effects. The research done at the University of Leicester has been funded by the Leicestershire and Rutland charity Hope Against Cancer.

Professor David Lambert commented:

"This work is still at a very early stage but has the potential to change the way we think about making drugs for pain related issues."

The new group of drugs, which were developed in the University of Ferrara and tested by the University of Leicester, is designed to produce pain relief by acting at two targets simultaneously. The two target idea may provide effective pain relief with less tolerance.

Hope Against Cancer has funded this 3-year PhD project at the University of Leicester to look at the long term effects of these new drugs, with a primary focus on drug tolerance.

Nikolaos Dietis, the PhD research student who is currently working on the project, said:

"Tolerance to strong painkillers like morphine involves complicated biological processes, aspects of which still remain questionable. Our research may provide some answers by designing new drugs that have multiple roles. We are now studying these drugs to see what they do in the long-term."

Dr Guerrini said:

"Pain is a very complicated condition, whose control and relief could be achieved with the use of drugs that act on two different targets in order to obtain pain relief more effectively."

The project at the University of Leicester could lead to further development of these new drugs that could even lead to future trials on cancer patients.

Professor Rowbotham commented:

"We need to further refine this work to enable studies to be performed in patients. This may be a relatively long-term process, but it offers a completely new approach to pain management for cancer patients in the future."


'/>"/>

Contact: Professor David Lambert
dgl3@le.ac.uk
01-162-525-694
University of Leicester
Source:Eurekalert

Related medicine news :

1. New Drugs, New Combinations Fight Breast Cancer
2. NICE guidelines ration affordable osteoporosis drugs
3. Bone Drugs May Beat Back Breast Cancer
4. Rehabilitation for Opiate Addiction Without Maintenance Drugs
5. Review and approval of oncology and hematology drugs at FDA from 2005 to 2007
6. Fake Drugs Bought on the Web Pose Big Health Risks
7. Scientists show how molecular switch helps pancreatic cancer beat drugs
8. Common antidepressant drugs linked to lactation difficulties in moms
9. Counterfeit Internet drugs pose significant risks and discourage vital health checks
10. Fertility drugs contribute heavily to multiple births
11. Scientists show how brain tumors outsmart drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... February 08, 2016 , ... Remember the old saying “rub ... According to Perry A~, author of “Calcium Bentonite Clay” the health benefits of integrating ... balancing and detoxifying the body. , A former motivational speaker, Perry A~ has since ...
(Date:2/8/2016)... ... ... Discover the Rocky Mountain region’s longest running and impressive garden and home ... get to see the most incredible gardens and home improvement experts that attend this ... Convention Center - 700 14th St. Denver CO, is an exciting event that Performance ...
(Date:2/8/2016)... ... 08, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to a ... derived from a cluster of melanin when exposed to sunlight. Although most moles are ... lifetime of embarrassment. Historically, mole removal has involved a painful, often expensive ...
(Date:2/8/2016)... ... , ... The schedule is now online for the largest and ... is being held May 25-29 at the Loews Chicago O’Hare Hotel, continues to give ... of chronic illness in children. , Very recent articles have cited 1 child in ...
(Date:2/7/2016)... , ... February 07, 2016 , ... Women's Excellence staff, ... Wear Red Day. National Wear Red Day is the first Friday each February ... disease and stroke cause 1 in 3 deaths among women each year – more ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... --> --> ... Technologies Market by Product (Radiofrequency, Ultrasound, Irreversible Electroporation, Cryotherapy, ... Ophthalmology, Gynecology) - Global Forecasts to 2020", published by ... forecast period of 2015 to 2020. The market is ... of 10.5% from 2015 to 2020. Browse ...
(Date:2/8/2016)... 2016 http://www.researchandmarkets.com/research/fqx6nz/global_skin ) ... Skin Protective Equipment Market 2016-2020" report to ... ) has announced the addition of the ... to their offering. --> ... the addition of the "Global Skin Protective ...
(Date:2/8/2016)... historic vote among its members this weekend, the Shinnecock Indian Nation voted ... dispensary on tribal land near Southampton . ... patients in the state,s Medical Cannabis Program. --> ... the state,s Medical Cannabis Program. --> Tribal members voted ... from the State of New York as a ...
Breaking Medicine Technology: