Navigation Links
New drugs, new ways to target androgens in prostate cancer therapy
Date:6/20/2012

AURORA, Colo. (June 20, 2012) - Prostate cancer cells require androgens including testosterone to grow. A recent review in the British Journal of Urology International describes new classes of drugs that target androgens in novel ways, providing alternatives to the traditional methods that frequently carry high side effects.

"In many ways, therapies for prostate cancer have led the way in the fight against the disease," says E. David Crawford, MD, investigator at the University of Colorado Cancer Center and review co-author. "The first effective oral therapy for any cancer was estrogen which was described in 1941. The first cancer biomarker that allowed diagnosis and staging was prostatic acid phosphatase back in 1938. Then there was little progress for over four decades."

During those 40 years, in which early work in prostate cancer led to Nobel prizes for researchers Charles Huggins and Andrew Schally, other cancer types capitalized on this research, notably developing hormone therapies targeting estrogen in breast cancer. But work in prostate cancer stalled.

"What we realized is that production of androgens like testosterone depends on an intact system in which the brain recognizes hormone levels, signals the pituitary to increase or decrease production, and the pituitary in turn sets the testes in motion. Additionally, by targeting the production of androgens by the testes, we could break that system at many other points," Crawford says.

For example, estrogen is similar enough to testosterone that administering estrogen to patients tricked the brain into thinking testosterone hormone levels were high with high presumed hormone levels, the brain sent no production signal to the pituitary. But estrogen therapy led to side effects including breast enlargement.

The next class of drugs, known as luteinizing hormone releasing hormones or LHRHs, intervened in this signaling chain at the level of the pituitary. Just as estrogen keeps th
'/>"/>

Contact: Erika Matich
erika.matich@ucdenver.edu
303-524-2780
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Leukemia inhibitory factor may be a promising target against pancreatic cancer
2. Identity Theft Expert Advises on Why Elders are Targets for Scams and Financial Abuse
3. Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target
4. Mount Sinai researchers develop a multi-target approach to treating tumors
5. Dana-Farber: Study reports first success of targeted therapy in type of non-small cell lung cancer
6. Scientists identify possible drug target for acute pancreatitis
7. Scientists identify new target to battle rheumatoid arthritis
8. Breathing during radiotherapy - how to hit the treatment target without causing collateral damage
9. Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
10. A closer look at PARP-1 reveals potential new drug targets
11. IBN discovers human neural stem cells with tumor targeting ability
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... 2015 Carinsurancequotesinfo.com has released a new ... cost auto insurance for flatbed trucks. , ... sometimes other vehicles. They are mainly used for commercial ... released blog post explains that by comparing multiple offers, ... and other commercial vehicles. , It is now possible ...
(Date:4/25/2015)... Islands, BWI (PRWEB) April 25, 2015 ... has celebrated three months of successfully welcoming visitors to ... 5, 2015. , As part of a major ... Providenciales airport was completely redesigned to speed up arrivals. ... the process of getting out of the airport and ...
(Date:4/25/2015)... York New York (PRWEB) April 25, 2015 ... that Dr. Jerry Blaivas has been chosen by the New ... for his contributions to medicine in the field of Urology. ... the best in his speciality, Genito-Urinary diseases. He was ... specifically in the field of urology. Not only did ...
(Date:4/25/2015)... 2015 For thirteen years, the Twin Cities ... education event in the nation! This year, on May 5th, ... US to take DI Day on the road by supporting ... CLU, ChFC, RHU, DIA, CLTC, Chief Executive Officer at Secura ... on the change by stating, "The first Twin Cities DI ...
(Date:4/24/2015)... 24, 2015 Multi Customer Discount , ... pumping ( http://www.zeitersseptics.com/multi-customer-discount.html ) of 1000-1500 gallons in Zeiter's ... program. This does not include any Dig fees, or ... per person. If someone is part of this group ... totaling approximately 2500 gallons or more, the cost would ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Quotes for Flatbed Trucks Available Online! 2Health News:The Tuscany on Grace Bay Celebrates Providenciales Airport Expansion With Summer Specials to Travelers! 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 3Health News:Secura Consultants Takes DI Day On The Road 2Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 2Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 3
... Qiao Xing,Mobile Communication Co., Ltd. (,Qiao Xing Mobile, or ... domestic manufacturers of mobile,handsets through its subsidiary CEC Telecom ... C7000A cardiograph mobile handset., The C7000A has ... will be able to perform a basic ...
... form of breast cancer are being tested in a ... six continents -- a clinical trial that investigators hope ... This trial, dubbed ALTTO (Adjuvant Lapatinib and/or Trastuzumab Treatment ... initiatives in which two large, academic breast cancer research ...
... affected by ... rare diseases, NEW YORK, Feb. ... Day will be launched on Friday 29,February...because it,s a rare day that ... Shire plc at:, http://media.medialink.com/WebNR.aspx?story=34701 ), Collectively, rare diseases aren,t ...
... Firm,s Growing Healthcare Practice, BROOKFIELD, Wis., Feb. ... human resources outsourcing company, has added,Gordon Warner to ... Services,Director., Warner brings extensive HR experience and ... Warner comes to Pinstripe from,M&I Bank in Milwaukee, ...
... 28 Millennium,Pharmaceuticals, Inc. (Nasdaq: MLNM ... 2008 Susquehanna Healthcare Conference will be webcast ... Investors section of the Company,s website, http://www.millennium.com ... The presentation will include an overview ...
... Idaho, Feb. 28 NightHawk,Radiology Holdings, Inc. (Nasdaq: ... groups across the United States, today announced,that Ernest G. ... of the,company,s Board of Directors for personal reasons. Mr. ... company intends to immediately begin a search,to identify a ...
Cached Medicine News:Health News:Qiao Xing Mobile's CECT Subsidiary Releases Newest Handset Model; C7000A Offers Cardiograph, 120 Days Ultra-Long Standby and 3.0'' LCD Screen 2Health News:Qiao Xing Mobile's CECT Subsidiary Releases Newest Handset Model; C7000A Offers Cardiograph, 120 Days Ultra-Long Standby and 3.0'' LCD Screen 3Health News:New study of targeted therapies for breast cancer -- model for global clinical trials 2Health News:New study of targeted therapies for breast cancer -- model for global clinical trials 3Health News:New study of targeted therapies for breast cancer -- model for global clinical trials 4Health News:VIDEO from Medialink and Shire plc: Rare Diseases Must Be Top of the Health Agenda 2Health News:VIDEO from Medialink and Shire plc: Rare Diseases Must Be Top of the Health Agenda 3Health News:Pinstripe Healthcare Group Adds Veteran HR Executive Warner as Client Services Director 2Health News:2008 Susquehanna Healthcare Conference to Webcast Millennium Presentation 2Health News:NightHawk Radiology Holdings, Inc. Announces Board Member Departure 2
(Date:4/24/2015)... 2015 Research and Markets ... of the "Lab Accessories Market by ... Station) & End User (OEM/Biotechnology & Pharmaceutical ... 2020" report to their offering. ... expected to reach $504.7 million by 2020 ...
(Date:4/24/2015)... Company, Inc. (NYSE: LCI ) today announced that ... facility to $120 million from $50 million.  The amended ... company to increase borrowings by a total of up ... commitments from existing lenders or new lending institutions.  The ... 2018.   "The amended credit facility, together ...
(Date:4/23/2015)... CHICAGO, Ill. , April 24, 2015  AbbVie ... Food and Drug Administration (FDA) has accepted its New ... company,s, all-oral, interferon-free, two direct-acting antiviral treatment of ombitasvir, ... for the treatment of adults with chronic genotype 4 ... regimen is the first all-oral, interferon-free therapy being evaluated ...
Breaking Medicine Technology:Global Lab Accessories Market Report 2015-2020 - Label Printer/ Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station 2Global Lab Accessories Market Report 2015-2020 - Label Printer/ Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station 3Lannett Expands Revolving Credit Facility To $120 Million 2U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 2U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 3U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 4U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 5U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 6U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 7
... compact Allegra X-22 Series is up to 10 inches/ ... library of 11 rotors, the Allegra X-22 Series is ... Features: Only 18 inches / 46 cm wide ... x g 3 different ways to Spin 1.5 ...
... Fractionation, Proteins and Viruses • ... with fixed-angle rotor • Spin ... 85 mL • Operating temperature ... C • Rotors certified by ...
... Eppendorf Multipurpose Centrifuges feature ... accommodate a variety of rotors ... are three centrifuges in one: ... centrifuge for cell harvesting; a ...
... MicroCentrifuge 6-Place Rotor has a standard 1.5ml rotor ... .4ml adapters. Easy operation (no switches to mess ... and press the plastic tab to open. Starts ... rpm and 2000 x g. Only five inches ...
Medicine Products: