Navigation Links
New drug targets vitamin D receptors in hormone resistant prostate cancers
Date:11/17/2010

A new anti-cancer drug aimed at vitamin D receptors on cancer cells has prompted encouraging responses in the levels of PSA (prostate specific antigen) in men with prostate cancer that has become resistant to hormonal therapies.

Results of the phase II(a) clinical trial will be presented at the 22nd EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Berlin today (Thursday). The trial found that when the new drug, inecalcitol, was combined with the existing, current therapy (docetaxel and prednisone) 83% of patients responded to the treatment with a drop in PSA levels of 30% or more within three months of the treatment. PSA levels are used as a marker for tumour activity and successful treatment shrinks cancer, leading to a drop in PSA levels in the blood.

"The PSA responses with this combination are encouraging," said Dr Jacques Medioni, who presented the findings. "It compares favourably with historical data showing that normally 65% of patients respond when treated with docetaxel alone. Furthermore, PSA levels declined by 50% in 67% of patients treated with inecalcitol, and biochemical relapse (when PSA levels start to go up again) did not occur for at least 169 days."

Now inecalcitol is to be tested further in more patients in a larger, phase II(b) clinical trial, which is expected to start in the second quarter of 2011.

Prostate cancer is a chronic disease, usually occurring in men over 50. It is the second most common cancer in men worldwide and an estimated 2.47 million men died from the disease in 2008 worldwide. Initially, male hormones drive the growth of most prostate cancers and so anti-hormonal drugs are effective in stabilising the cancer for several months or years. However, at some point the tumour usually progresses and becomes resistant to anti-hormonal treatments and then it is defined as being hormone-refractory or hormone-resistant prostate cancer (HRPC). Once this happens the p
'/>"/>

Contact: Emma Mason
wordmason@mac.om
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Drug Targets Faulty Process That Drives Cystic Fibrosis
2. Efforts to combat pneumonia among 15 high-burdened countries fall short of recommended targets
3. Texas Center for Cancer Nanomedicine targets 2 tough cancers
4. Scientists turn a new leaf to discover a compound in daffodils that targets brain cancer
5. Immune systems bare essentials used to speedily detect drug targets
6. Smart drug targets new mutation, dramatically shrinks aggressive sarcoma and lung cancer
7. New program targets research on reducing deaths due to prescription opioid overdose
8. New investigational compound targets pancreatic cancer cells
9. TGen finds therapeutic targets for rare cancer in children
10. MSU targets womens health research with $2.5 million grant
11. Researcher targets gene regulators on link between arsenic, cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... With the Affordable Care Act (ACA) open enrollment period ... for Research (AIR) finds that three out of four Americans ... 42 percent say they are not likely or only somewhat ... coverage. , The AIR survey found wide gaps in Americans’ ... correctly how much they owe for a routine doctor’s visit. ...
(Date:10/22/2014)... 2014 Although there are only 24 hours in ... people who have trouble finding time within their busy schedules for ... long periods of time to get in shape. Here are five ... the go. , Change Up Your Commute , Consider riding ... add some exercise into your daily routine. If you must use ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter ... women undergoing in vitro fertilization (IVF) are only about half ... popular assisted reproduction technique, new research indicates, and the racial ... the study, about 31 percent of white patients became pregnant ... Analyzing more than 4,000 IVF cycles over two years ...
(Date:10/22/2014)... Dennis Thompson HealthDay Reporter ... officials on Monday officially tightened guidelines for health workers treating ... exposure and use of a respirator at all times. ... issue the tougher rules after two Dallas nurses contracted Ebola ... United States, Liberian national Thomas Eric Duncan. Nina Pham is ...
(Date:10/20/2014)... 2014 The Advocator Group, LLC ... the American Foundation for Suicide Prevention’s (AFSP) Out of ... a not-for-profit organization that hosts hundreds of community walks ... events are used to help understand and prevent suicide ... relationships as well. , The Advocator Group shares ...
Breaking Medicine News(10 mins):Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3
... study by the American Psychological Association (APA) has found ... and young// women in advertising and media is harmful ... complete the report, the APA Task Force on the ... and effects of virtually every form of media, including ...
... successfully developed artificial teeth that they say could replace ... similar procedures in humans. ,In the technique, ... implanted into the mouths of adult mice and said ... the online edition of Australia's The Daily Telegraph. ...
... actor Saif Ali Khan, who was rushed to a city ... better and recovering from severe exertion, hospital sources said Monday. ... will be kept under observation for the next two days, ... 36, was rushed to Lilavati Hospital Sunday evening after suffering ...
... needle in the haystack as years of scientific slogging ... unknown genetic material that causes autism. ,The ... treatment of autism has been met with considerable excitement ... international team from 8 countries and led by Canadian ...
... its concerns about HIV-infected cases growing by leaps and bounds in ... the country’s most remote regions. , Talking ... 169,000 to 216,000 HIV cases in the most populous Muslim ... million. ,Higher incidences are seen among a special ...
... been closed to patients and visitors after an outbreak of ... members of the hospital and many patients have been affected ... for causing disorders affecting the intestine resulting in severe vomiting, ... last for two to three days but are severely pronounced ...
Cached Medicine News:Health News:Sexualization Linked to Mental Health Problems in Girls and Women 2Health News:New Gene Linked to Autism Discovered 2
(Date:10/22/2014)... 2014  Early symptoms of diabetic eye and ... new technology, coupled with yearly, comprehensive eye exams, ... detection of eye diseases, including those associated with ... left untreated, these diseases can potentially lead to ... Recently, optometric researchers have deployed a new tool ...
(Date:10/22/2014)... 2014 Influenza will affect as many as 200,000 ... the United States as high as 49,000 people.  ... is from person to person in respiratory droplets of coughs ... of death, but kills much fewer people each year than ... human fluids including sweat, saliva, blood and other bodily fluids. ...
(Date:10/22/2014)... InVivo Therapeutics Holdings Corp. (OTCQB: NVIV) based ... spinal cord injury (SCI) treatment with their novel Neuro-Spinal ... tissue regrowth in the spinal cord area when cells ... approved polymer, the scaffold ultimately breaks down to water ... body. NVIV has recently attracted significant investor attention with ...
Breaking Medicine Technology:Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 2Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 3WholeHealth Products is proud to be releasing its Influenza A and B combo test, on the heels of the announcing of its phase 2 completion of the Rapid Ebola Test 2InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 2InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 3
... SIRO Clinpharm, a leading full service Clinical Research Organization ... SIRO has developed a long term plan to align with ... charter is to transform SIRO into a global leader in ... continuing to build and enhance the biopharma service catalog for ...
... 2012  Amgen Inc. ("Amgen") (NASDAQ: AMGN ) announced ... tender offer (the "Offer") by a wholly owned subsidiary, "Merger ... Micromet, Inc. ("Micromet") (NASDAQ: MITI ) for $11.00 ... 12:00 midnight, New York City time, at the end of ...
Cached Medicine Technology:SIRO Clinpharm Announces Appointment of Gopakumar Menon as Chief Executive Officer to Lead the Global Clinical Research Organization 2Amgen Completes Tender Offer for Outstanding Shares of Micromet, Inc. 2Amgen Completes Tender Offer for Outstanding Shares of Micromet, Inc. 3Amgen Completes Tender Offer for Outstanding Shares of Micromet, Inc. 4
Stainless steel plain Steinman Pins available in point types A through F....
Full pin skeletal traction pins with cove point....
Calibrated Guide Pins have a 12.7 mm calibration and are available in plain, with a threaded tip, or with a trocar point....
Knowles Pins are available in 9" (228mm) overall length with 9/64" (3.5mm) shaft diameter and 1/4" (6.4mm) square bead....
Medicine Products: