Navigation Links
New drug targets vitamin D receptors in hormone resistant prostate cancers
Date:11/17/2010

A new anti-cancer drug aimed at vitamin D receptors on cancer cells has prompted encouraging responses in the levels of PSA (prostate specific antigen) in men with prostate cancer that has become resistant to hormonal therapies.

Results of the phase II(a) clinical trial will be presented at the 22nd EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Berlin today (Thursday). The trial found that when the new drug, inecalcitol, was combined with the existing, current therapy (docetaxel and prednisone) 83% of patients responded to the treatment with a drop in PSA levels of 30% or more within three months of the treatment. PSA levels are used as a marker for tumour activity and successful treatment shrinks cancer, leading to a drop in PSA levels in the blood.

"The PSA responses with this combination are encouraging," said Dr Jacques Medioni, who presented the findings. "It compares favourably with historical data showing that normally 65% of patients respond when treated with docetaxel alone. Furthermore, PSA levels declined by 50% in 67% of patients treated with inecalcitol, and biochemical relapse (when PSA levels start to go up again) did not occur for at least 169 days."

Now inecalcitol is to be tested further in more patients in a larger, phase II(b) clinical trial, which is expected to start in the second quarter of 2011.

Prostate cancer is a chronic disease, usually occurring in men over 50. It is the second most common cancer in men worldwide and an estimated 2.47 million men died from the disease in 2008 worldwide. Initially, male hormones drive the growth of most prostate cancers and so anti-hormonal drugs are effective in stabilising the cancer for several months or years. However, at some point the tumour usually progresses and becomes resistant to anti-hormonal treatments and then it is defined as being hormone-refractory or hormone-resistant prostate cancer (HRPC). Once this happens the p
'/>"/>

Contact: Emma Mason
wordmason@mac.om
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Drug Targets Faulty Process That Drives Cystic Fibrosis
2. Efforts to combat pneumonia among 15 high-burdened countries fall short of recommended targets
3. Texas Center for Cancer Nanomedicine targets 2 tough cancers
4. Scientists turn a new leaf to discover a compound in daffodils that targets brain cancer
5. Immune systems bare essentials used to speedily detect drug targets
6. Smart drug targets new mutation, dramatically shrinks aggressive sarcoma and lung cancer
7. New program targets research on reducing deaths due to prescription opioid overdose
8. New investigational compound targets pancreatic cancer cells
9. TGen finds therapeutic targets for rare cancer in children
10. MSU targets womens health research with $2.5 million grant
11. Researcher targets gene regulators on link between arsenic, cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... December 26, 2014 The microscopy ... of 7.2% to reach $5,756.0 million by 2019. ... microscopy market. The electron microscopes product segment is ... forecast period. , Rising focus on nanotechnology, technological ... of the microscopy market. , Get Full Copy ...
(Date:12/25/2014)... The report “Nintedanib (Colorectal Cancer) ... on the current treatment landscape, unmet needs, current ... market. Stivarga is a drug which is used ... Boehringer Ingelheim is developing nintedanib (BIBF-1120), an orally ... CRC in the US, Europe, and Japan. The ...
(Date:12/25/2014)... “Every three months the trends for evening dresses ... will be one of the hottest styles in the next ... the company releases 26 A-line sweetheart evening dresses, and announces ... , “We are trying our best to help a lady ... Along with affordable prices, we provide discounted delivery costs to ...
(Date:12/25/2014)... Angeles, CA (PRWEB) December 25, 2014 The ... Dolcemaschio was created in honor of a true 9/11 ... at two film festivals including the 24 hours of Nuremberg ... Festival in Bangladesh. , Actress, screenwriter and director ... helped produce this film together with her husband, Gregory ...
(Date:12/25/2014)... Woodland Hills, California (PRWEB) December 25, 2014 ... in her home in Woodland Hills, California after an ... Harris passed away on Christmas Eve evening in her ... battle with aggressive metastatic breast cancer. ... International for over forty years, she pioneered and championed ...
Breaking Medicine News(10 mins):Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 4Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4
... Total Health Through Free Online Makeover , , DALLAS, ... 1 killer of women in the U.S. That,s why the American ... country to listen to their hearts and turn their personal choices ... Red BetterU is not about fad diets and new exercise trends, ...
... supplies water to Sun City, Sun City West, and Town of ... 1 Arizona American Water will supply water to emergency services ... Youngtown as part of an organized effort by the Salvation Army ... here in the Arizona desert easily exceed 110 degrees in the ...
... estimated 200,000 people have been infected in U.S. , MONDAY, ... been reported in all 50 states, with the total number ... Monday. , , "It,s accurate to say that there are ... this flu," said Tom Skinner, a spokesman for the U.S. ...
... ,unintended consequences, researchers say , MONDAY, June 1 (HealthDay ... have dropped sharply since the government,s warning of an ... taking antidepressants, a new analysis finds. , Researchers at ... Drug Administration,s advisories about the use of selective serotonin ...
... , PITTSBURGH, June 1 , , WHAT: ... invitation to testify before the U.S. House of Representatives Judiciary Subcommittee ... Delay: Are Patent Settlements That Delay Generic Drug Market Entry Anticompetitive?" ... Rep. John Conyers Jr. (D-MI). , , WHO: ...
... Feature Nearly 100 Exhibits, Career Fair, Forums on Health Care and ... Duo Mary Mary to Headline Entertainment*** , , CHICAGO, June ... will bring its "Life Festival" event to Chicago on ... feature high-profile speakers such as TV personality James Brown (J.B. ...
Cached Medicine News:Health News:Go Red For Women(R) Launches 12-Week Program to Improve Heart Health and Save Lives 2Health News:Go Red For Women(R) Launches 12-Week Program to Improve Heart Health and Save Lives 3Health News:Arizona American Water and Salvation Army Offer Aid on Hottest Days 2Health News:Swine Flu Now Reported in All 50 States 2Health News:Swine Flu Now Reported in All 50 States 3Health News:Swine Flu Now Reported in All 50 States 4Health News:Swine Flu Now Reported in All 50 States 5Health News:Swine Flu Now Reported in All 50 States 6Health News:Swine Flu Now Reported in All 50 States 7Health News:Swine Flu Now Reported in All 50 States 8Health News:Swine Flu Now Reported in All 50 States 9Health News:Swine Flu Now Reported in All 50 States 10Health News:Swine Flu Now Reported in All 50 States 11Health News:Depression Treatment Wanes Following FDA Warnings 2Health News:Depression Treatment Wanes Following FDA Warnings 3Health News:AARP to Host Cross-Generational 'Life Festival' in Chicago, June 5-6 2
(Date:12/24/2014)... 23, 2014  Lockton Dunning Benefits, the ... announced the addition of Vice President Kim ... Dunning,s Pharmacy Consulting team, Excelsior Solutions. ... experience to the position.  Most recently, she worked ... Diplomat Specialty Pharmacy, where she has held various ...
(Date:12/24/2014)... CHENGDU, China , Dec. 23, 2014 /PRNewswire/ ... a pharmaceutical company that specializes in patented biopharmaceutical, ... active pharmaceutical ingredients (API) today announced that the ... for its Good Manufacturing Practice (GMP) certificate of ... & Drug Administration,s (CFDA). The public notice period ...
(Date:12/24/2014)... N.C. , Dec. 23, 2014  Endo Pharmaceuticals ... ENDP ) (TSX: ENL), and BioDelivery Sciences International, ... they have submitted a New Drug Application (NDA) for ... Drug Administration (FDA).  Buprenorphine HCl Buccal Film is under ... require daily, around-the-clock, long-term opioid treatment and for which ...
Breaking Medicine Technology:Kim Foerster Joins Lockton Companies 2TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5
... Inc. (NYSE: ALR ) (the "Company") announced ... of its consent solicitations commenced on May 31, 2011 ... "Proposed Modifications") governing its 9.0% Senior Subordinated Notes due ... 2018 (the "8.625% Notes") and 7.875% Senior Notes due ...
... Inc., (OTC BB: NWCI) a cardiac diagnostic technology provider, ... scheduled to present at the Wells Fargo Securities Healthcare ... 2011, at The InterContinental Boston. Mr. Renz, presentation is ... Investors planning to attend the conference ...
Cached Medicine Technology:NewCardio to Present at Wells Fargo Securities Healthcare Conference 2NewCardio to Present at Wells Fargo Securities Healthcare Conference 3
... has the right product for any patient ... intubated patients to patients with tracheotomies. These ... and critical care applications., ,The Unti-Mist ... patients and staff members. This entire product ...
Combination heat and moisture exchanger and bacterial/viral filters for Anesthesia and Respiratory applications....
Indications For Usage: ,Adult (recommended tidal volume >150ml), single patient use on anesthetized patients and respiratory care patients who require a breathing circuit. The product is intended to ...
Indications For Usage: ,Pediatric (recommended tidal volume 70-250ml), single patient use on anesthetized patients and respiratory care patients who require a breathing circuit. The product is intend...
Medicine Products: