Navigation Links
New drug target improves memory in mouse model of Alzheimer's disease
Date:3/7/2012

Researchers at the University of California, San Diego, the Medical University of South Carolina, the University of Cincinnati, and American Life Science Pharmaceuticals of San Diego have validated the protease cathepsin B (CatB) as a target for improving memory deficits and reducing the pathology of Alzheimer's disease (AD) in an animal model representative of most AD patients. The study has been published in the online edition of the Journal of Alzheimer's Disease.

According to investigator Vivian Y. H. Hook, PhD, professor of the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences and professor of neurosciences, pharmacology and medicine at the UCSD School of Medicine, the study is important because it could lead to new therapeutics that improve the memory deficits of AD.

Abnormal accumulation of brain amyloid-β peptides (Aβ) is thought to cause the memory loss and amyloid plaque pathology of AD. Aβ peptides are "cut" out from a larger protein called the amyloid precursor protein (APP) by an enzymatic "scissor" called β-secretase, and aggregate to form plaques in the brain regions responsible for memory. Inhibiting the β-secretase "scissors" from "cutting" the APP with a drug would reduce brain Aβ levels and thereby improve memory deficits and reduce amyloid plaque pathology. The vast majority of AD patients have wild-type (WT) β-secretase activity and thus the WT β-secretase has been a target of great interest for a long time.

Another protease, BACE1, has long been thought to be the -secretase involved in AD pathology, because deleting that gene from animal models reduces brain A and plaque pathology. However, deleting the BACE1 gene was reported to make memory deficits worse in a transgenic model having WT β-secretase activity.

Hook and colleagues set off to find a WT β-secretase target, which improves memory deficits while reducing amy
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Marker of Ewing sarcoma: Potential new drug target?
2. Dana-Farber and Sanford-Burnham Institute license flu-targeting antibodies to Genentech and Roche
3. New therapeutic target for most common solid cancer in childhood?
4. Fans Spread the Love on Target Facebook Page and Help Donate $1 Million to Five Charities
5. New Multivitamins Target Concern Over China's Quality Problems
6. Targeted delivery of losartan reduces liver inflammation and scarring
7. New Study: Improved Immune System with Gene-Eden, a Natural Antiviral Supplement that Targets Chronic Viruses
8. TV Ads Target House Members Who Voted for Obamacare
9. Targeting leukemia cells gene addiction presents new strategy for treatment
10. Hot Pepper Itch Remedy Targets Kidney Disease Patients Suffering From Chronic Pruritus
11. Americans for Responsible Health Care Launch Radio Ads Targeting Seven Democrats, Warning The People Are Watching...
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... FL (PRWEB) September 22, 2014 ... than 2,000 physicians, today Clearwater Clinical ... ClearSCOPE Endoscope Adaptor for smartphones. ClearSCOPE ... video from virtually any endoscope and smartphone. , ... adaptor in response to frustrations over the cost, ...
(Date:9/22/2014)... On Saturday, September 27, 2014, La Comunidad Hispana ... fair ¡Vive tu vida! Get Up! Get Moving!® This event ... health and wellness for people of all ages and all ... public, will be held at Anson B. Nixon Park, 100 ... pm. , “This is a wonderful event each year ...
(Date:9/22/2014)... Steven Reinberg HealthDay Reporter ... six-year study of people with type 2 diabetes found ... in preventing heart attacks, strokes and deaths. But intensive ... found. For the study, investigators followed nearly 8,500 ... had their blood pressure and blood sugar levels strictly ...
(Date:9/22/2014)... September 22, 2014 At the ... nonprofit Seafood Nutrition Partnership (SNP) announced the successful ... Healthy: A Cardiovascular Risk Reduction Program for Women. ... understand and mitigate their risk of heart disease ... Action, a plan for addressing significant global challenges ...
(Date:9/22/2014)... The Drive Against Domestic Violence ( ... Ben Talei, MD - a Beverly Hills Facial Plastic ... brothers have planned to drive across the country during ... raise funds and awareness for the National Coalition Against ... the American Academy of Facial Plastic & Reconstructive Surgery's ...
Breaking Medicine News(10 mins):Health News:ClearSCOPE 2.0 Endoscope Adaptor for Smartphones Announced; Endoscopic Video Capture Reinvented 2Health News:La Comunidad Hispana Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 2Health News:La Comunidad Hispana Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 3Health News:Tight Blood Sugar Control Doesn't Prevent Strokes in Diabetics: Study 2Health News:Tight Blood Sugar Control Doesn't Prevent Strokes in Diabetics: Study 3Health News:At 2014 Clinton Global Initiative Annual Meeting, Seafood Nutrition Partnership Announces Pilot Program to Reduce Women’s Heart Disease Risks 2Health News:At 2014 Clinton Global Initiative Annual Meeting, Seafood Nutrition Partnership Announces Pilot Program to Reduce Women’s Heart Disease Risks 3Health News:At 2014 Clinton Global Initiative Annual Meeting, Seafood Nutrition Partnership Announces Pilot Program to Reduce Women’s Heart Disease Risks 4Health News:FOX 5 News Story - Dr. Ben Talei a Beverly Hills Facial Plastic Surgeon organizes the Drive Against Domestic Violence & Botox-for-a-Cause as he Drives across the country 2Health News:FOX 5 News Story - Dr. Ben Talei a Beverly Hills Facial Plastic Surgeon organizes the Drive Against Domestic Violence & Botox-for-a-Cause as he Drives across the country 3
... Berger & Grossmann LLP is issuing the following statement regarding the Sunrise Senior Living, Inc. Securities Litigation. , , ... UNITED STATES DISTRICT COURT, ... INC. Master File, SECURITIES LITIGATION ... Relates to: All Cases, ...
... suggests, , , MONDAY, April 20 (HealthDay News) -- Want to live ... manage your stress. , A new study found that those were ... 100, and longevity is thought to run in families. , "We ... set the children of centenarians apart from other people the same ...
... HOLLYWOOD, Calif., April 20 IPC The Hospitalist ... hospitalist physician group practice company, announced today that it will ... on May 4, 2009, after the market close.A conference call ... (2:00 p.m. PT) on May 4, 2009 and will be ...
... "With Hurricanes Katrina, Rita and Ike we ... and healthcare providers navigate through chaos created by ... Davies, M.D., a seasoned critical care physician and ... which enable communication between patients, their physicians, hospitals ...
... with Picoplatin as Second-Line Therapy for Small Cell Lung ... Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ), a ... of its Phase 2 clinical trial of picoplatin in ... were published in the April 20, 2009, print ...
... 20, 2009 Forest Laboratories, Inc. (NYSE: FRX ... announced today that Savella(TM) (milnacipran HCl), a selective serotonin and ... will be shipped to wholesalers on April 24th and will ... Savella was approved by the U.S. Food and Drug Administration ...
Cached Medicine News:Health News:All Persons Who Purchased or Acquired the Common Stock of Sunrise Senior Living, Inc. ('Sunrise') Between February 26, 2004 and July 28, 2006, Inclusive, and Were Damaged Thereby (The 'Class') 2Health News:All Persons Who Purchased or Acquired the Common Stock of Sunrise Senior Living, Inc. ('Sunrise') Between February 26, 2004 and July 28, 2006, Inclusive, and Were Damaged Thereby (The 'Class') 3Health News:Outgoing Nature Could Get You to 100 2Health News:Outgoing Nature Could Get You to 100 3Health News:IPC The Hospitalist Company, Inc. to Report First Quarter 2009 Financial Results 2Health News:PatientCentral Technologies, LLC and VerdaSee Solutions, Inc. Team Up With Congressional Staff in Washington, DC for Disaster Preparedness 2Health News:PatientCentral Technologies, LLC and VerdaSee Solutions, Inc. Team Up With Congressional Staff in Washington, DC for Disaster Preparedness 3Health News:PatientCentral Technologies, LLC and VerdaSee Solutions, Inc. Team Up With Congressional Staff in Washington, DC for Disaster Preparedness 4Health News:Poniard Announces Publication of Results of Picoplatin Phase 2 Study in Journal of Clinical Oncology 2Health News:Poniard Announces Publication of Results of Picoplatin Phase 2 Study in Journal of Clinical Oncology 3Health News:Poniard Announces Publication of Results of Picoplatin Phase 2 Study in Journal of Clinical Oncology 4Health News:Poniard Announces Publication of Results of Picoplatin Phase 2 Study in Journal of Clinical Oncology 5Health News:Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce Commercial Availability of Savella(TM) 2Health News:Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce Commercial Availability of Savella(TM) 3Health News:Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce Commercial Availability of Savella(TM) 4Health News:Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce Commercial Availability of Savella(TM) 5Health News:Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce Commercial Availability of Savella(TM) 6
(Date:9/22/2014)... Sept. 22, 2014 China Nepstar Chain Drugstore Ltd. (NYSE: ... drugstore chain in China based on the ... its 2014 Annual General Meeting of Shareholders (the "AGM") on October ... held at the meeting room of the Company at 6th Floor, ... , Guangdong Province 518054, ...
(Date:9/19/2014)... A pharmaceutical executive in the market research ... he wanted the research and consulting firm to explore: ... for secondary research) to maximize efficiency and maintain a ... , Automation of market research processes for efficient ... to implement and manage those automated systems ...
(Date:9/19/2014)... 19, 2014 /PRNewswire-iReach/ -- Market Research Report ... 2009-2019 is a professional and in-depth market ... industry. The report firstly reviews the basic ... application and manufacturing technology. The report then ... Oxybutynin Hydrochloride listing their product specification, capacity, ...
Breaking Medicine Technology:China Nepstar Chain Drugstore Schedules Annual General Meeting of Shareholders for October 22, 2014 2In Era of Competing Needs, Market Research Groups Under Pressure to Utilize Automation and External Staffing 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 4Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 5
... Cosmetic Surgery hopes to raise awareness of some of the ... cosmetic surgery industry through the launch of a series of ... on the subject, such as question and answer sessions, conferences ... new initiatives online, that it hopes people from all over ...
... PINE BROOK, N.J., Oct. 24, 2011 Elusys Therapeutics, ... of antibody therapeutics, announced today that it is initiating ... of Anthim (ETI-204), the company,s anti-toxin in late-stage development ... inhaled anthrax. The company also announced it has successfully ...
Cached Medicine Technology:Liberate Cosmetic Surgery aims to Highlight Cosmetic Surgery Industry Issues 2Elusys Initiates Third Clinical Safety Study of Anthim, a New Anthrax Treatment; Company Successfully Completes Manufacturing at Commercial Scale 2Elusys Initiates Third Clinical Safety Study of Anthim, a New Anthrax Treatment; Company Successfully Completes Manufacturing at Commercial Scale 3
... Sun Med TruFlow™ Oxygen flowmeter with a ... warranty covering calibration and manufacturing defects. A ... meet most needs. Also available with all ... power take-off and double unit configurations. Our ...
... adults, the entire series of time-tested Timeter® ... the needs of care providers and patients ... accuracy. You can see it in the ... performance, year after year. Every Timeter® Classic ...
The Soft-Touch Timeter® Flowmeter is durable, long-lasting and easy to maintain. Timeter ® by Allied Flowmeters: Quality Plus Value....
The Soft-Touch Timeter® Flowmeter is durable, long-lasting and easy to maintain. Timeter ® by Allied Flowmeters: Quality Plus Value....
Medicine Products: