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New drug strategies for Alzheimer's, multiple sclerosis examined at UH
Date:10/20/2011

fic research tools and potential therapeutics for a multitude of conditions.

One successful example of using ERβ as a drug target has proven the receptor as an effective cancer cell combatant in breast cancer tissue. Closer examination of human breast cancer cell lines determined that, while ERα alone may stimulate the development of tumors, the combined presence of ERα and ERβ reduced and prevented tumor development.

"These modulators are well-established in the treatment of breast cancer and osteoporosis," Gustafsson said. "We now are pushing the limits of their influence to develop new treatments and ultimately save lives."

CNRCS researchers continue to examine the two estrogen receptor subtypes in various animal disease models, focused on identifying therapeutic opportunities. ERβ remains the most likely target for expanding treatments beyond breast cancer. The widespread involvement of ERβ presents the greatest probability for impacting these other diseases. Early results indicate that the selective activation of ERβ may represent a safe, disease-modifying therapy for the treatment of Alzheimer's disease.


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Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

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