Navigation Links
New drug shrinks cancer in animals, U-M study shows
Date:4/6/2011

ANN ARBOR, Mich. A study led by researchers at the University of Michigan Comprehensive Cancer Center showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.

The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppressor function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53.

"For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, Ph.D., Warner-Lambert/Parke-Davis Professor in Medicine and director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.

Wang presented the study at the American Association for Cancer Research 102nd annual meeting.

Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and sanonfi-aventis, researchers showed that these new drugs shrank tumors without significant side effects.

Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1

Related medicine news :

1. Stem Cell Therapy Shrinks Enlarged Hearts
2. Smart drug targets new mutation, dramatically shrinks aggressive sarcoma and lung cancer
3. Cholesterol-lowering drug shrinks enlarged prostates in hamster model
4. VCU study: Researchers discover a drug combination that shrinks tumors in vivo
5. As girth grows, risk of sudden cardiac death shrinks
6. Drug for advanced kidney cancer shrinks tumors prior to surgery
7. Fox Chase researchers find that fish oil boosts responses to breast cancer drug tamoxifen
8. Fox Chase researchers report that naproxen reduces tumors in a mouse model of colon cancer
9. Overall Health May Be Key to Beating Breast Cancer
10. Immune-Boost Treatment Might Help Some With Advanced Colon Cancer
11. An international study in China finds strawberries may slow precancerous growth in the esophagus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... 2017 , ... Paragon and IOTA ... the cannabis industry move towards greater legitimacy. By incorporating IOTA’s unique approach to ... lower fees. Paragon will build a fully verifiable database to track prescriptions, and ...
(Date:8/19/2017)... Toronto, ON (PRWEB) , ... August 19, 2017 , ... ... of the of NaturallyCurly.com® The Curl Leaders, Editors’ Choice 2017 Award for the second ... must-have accessory for hair stylists and curlies alike was voted Best Moisturizer for Type ...
(Date:8/19/2017)... ... August 19, 2017 , ... ... diverse community of over 1,000 passionate employees, caregivers, volunteers, thought leaders, researchers, educators ... Stonegate changed ownership, it was time to refresh the carpeting with the goal ...
(Date:8/18/2017)... ... August 19, 2017 , ... Mr. ... presided over the Amazing Thailand Health and Wellness Tourism Showcase 2017 yesterday, which ... Pakprot, Deputy Governor for Tourism Products and Business at TAT said, “Thailand has ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... (“Quick”), a highly specialized asset-light logistics provider of complex transport solutions for ... agreement to purchase Unitrans International Corporation, a division of Roadrunner Transportation Systems, ...
Breaking Medicine News(10 mins):
(Date:8/17/2017)... Aug. 17, 2017 MJAC2017 , the premier ... Broadcast Media, today reveals its leading lineup. ... a global cannabis innovator specializing in the development of pharmaceutical ... conference. MassRoots, Rambridge™ and The Green Organic Dutchman are gold ... Namaste Vapes™ as silver sponsors. ...
(Date:8/15/2017)... Aug. 15, 2017  Axium Pharmaceuticals Inc., the creator of the drug ... in the beginning stages of an IPO. The ... with the average cost of a prescription epilepsy drug being $450.00-$1200.00 for ... AXIUM PHARMACEUTICALS, INC ... Another staggering figure is the fact that Americans spent ...
(Date:8/10/2017)... Colo. , Aug. 10, 2017  Physical Rehabilitation Network ... located in Lakewood, Colorado . The reputable ... Jeff Lipkin , PT, DPT with his staff of four ... University of Pittsburgh and brings over 10 years of experience ... Belmar PT marks the 10th PRN clinic in ...
Breaking Medicine Technology: