Navigation Links
New drug shrinks cancer in animals, U-M study shows
Date:4/6/2011

ANN ARBOR, Mich. A study led by researchers at the University of Michigan Comprehensive Cancer Center showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.

The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppressor function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53.

"For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, Ph.D., Warner-Lambert/Parke-Davis Professor in Medicine and director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.

Wang presented the study at the American Association for Cancer Research 102nd annual meeting.

Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and sanonfi-aventis, researchers showed that these new drugs shrank tumors without significant side effects.

Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1

Related medicine news :

1. Stem Cell Therapy Shrinks Enlarged Hearts
2. Smart drug targets new mutation, dramatically shrinks aggressive sarcoma and lung cancer
3. Cholesterol-lowering drug shrinks enlarged prostates in hamster model
4. VCU study: Researchers discover a drug combination that shrinks tumors in vivo
5. As girth grows, risk of sudden cardiac death shrinks
6. Drug for advanced kidney cancer shrinks tumors prior to surgery
7. Fox Chase researchers find that fish oil boosts responses to breast cancer drug tamoxifen
8. Fox Chase researchers report that naproxen reduces tumors in a mouse model of colon cancer
9. Overall Health May Be Key to Beating Breast Cancer
10. Immune-Boost Treatment Might Help Some With Advanced Colon Cancer
11. An international study in China finds strawberries may slow precancerous growth in the esophagus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... ... conditions and Make-A-Wish grants the most heartfelt wishes of these children. The ... of medical treatment. President and CEO of Make-A-Wish Mississippi, Brent Wilson said, ...
(Date:5/5/2016)... ... ... Long Island’s fastest growing comprehensive eye care provider, North Shore Eye ... Valkenburg, MD as part of their ongoing effort to increase ophthalmic coverage in their ... of North Shore Eye Care. , “We are extremely proud to welcome ...
(Date:5/5/2016)... ... ... TIME for Kids and The ZAC Foundation – a national leader in drowning ... million children with important water safety messages before summer break begins. , ... in children one to 6 years of age. TIME for Kids and The ...
(Date:5/5/2016)... ... , ... In honor of National Nurses Week 2016, Aya Healthcare , ... to thank a nurse who's made a difference in their life. From Friday, May ... Cross of San Diego/Imperial Counties (up to $10,000) every time someone tells them via ...
(Date:5/5/2016)... ... ... Lung Institute will celebrate its three-year anniversary on May 14 by giving away a ... of May. To date, the Lung Institute has treated over 2,000 people at their five ... to the success of this treatment and to the patients who refuse to give up,” ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... 2016 Research and ... Thalassaemia Market and Competitive Landscape Highlights - ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) ... Competitive Landscape Highlights - 2016, provides comprehensive ... Thalassaemia market valuations and forecast, Thalassaemia products ...
(Date:5/4/2016)... May 4, 2016 According to ... entitled "Brain Computer Interface Market - Global Industry Analysis, Size, ... brain computer interface (BCI) market  is expected to reach ... is estimated to expand at a CAGR of 14.9 ... A BCI device provides collaboration between the ...
(Date:5/4/2016)... -- According to market research "Global Computed Tomography ... 2022 - Industry Insights by Slice Type (High, Mid and ... P&S Market Research, the global computed tomography market ... expected to grow at a CAGR of 5.0% during 2016-2022. ... expected to witness the faster growth, CAGR of 5.3%, during ...
Breaking Medicine Technology: