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New drug shows promising results for psoriatic arthritis
Date:4/7/2009

50 percent and at least 70 percent improvement.

The results showed that golimumab was efficacious and generally well tolerated. An ACR20 response was achieved at week 14 by 51 percent of patients receiving 50mg and 45 percent of those receiving 100mg, compared with 9 percent of placebo-treated patients. In addition, significantly more golimumab-treated patients than placebo-treated patients achieved ACR50 and ACR70 responses and those who initially showed little improvement and switched from placebo to golimumab or increased their dosage also showed improvement. Patients treated with the drug had significant improvement in physical function and health-related quality of life, as well as significant improvement in enthesitis, an inflammation where muscles attach to bones. In addition to improving arthritic symptoms, golimumab also improved psoriasis symptoms: 40 percent of the 50 mg group and 58 percent of the 100 mg group had at least 75 percent improvement in psoriasis symptoms, compared with 3 percent of the placebo group. "The safety profile of golimumab in psoriatic arthritis was similar to other anti-TNF agents that have been studied in this disease. Subcutaneous administrations were well tolerated. Only a small number of patients had injection site reactions, which were mostly mild.

This was also the first placebo-controlled study evaluating the effect of an anti-TNFα on nail psoriasis, which affected about 70 percent of the patients involved in the study. Significant improvements in nail symptoms were seen in those treated with golimumab as early as week 14 and were maintained or improved through the end of the study period.

The authors conclude that "subcutaneous golimumab (at doses of 50 mg and 100 mg) administered every 4 weeks significantly improved active psoriatic arthritis and associated skin disease." Longer-term data on golimumab's efficacy and safety will be reported in the future.


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Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

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