Navigation Links
New drug shows promising results for psoriatic arthritis
Date:4/7/2009

Psoriatic arthritis affects about 11 percent of patients with psoriasis. Anti-tumor necrosis factor α (anti-TNFα) agents, which block signaling molecules that induce inflammation, improve the symptoms of psoriatic arthritis. Golimumab is a new human monoclonal antibody that works against TNFα and has been shown to be beneficial within two weeks of the first subcutaneous injection in a phase II rheumatoid arthritis trial. A new phase III, multicenter, randomized, double-blind, placebo-controlled trial, the largest of its kind to be completed with a biologic agent to treat psoriatic arthritis and the first placebo-controlled study evaluating the effect of a TNF inhibitor on nail psoriasis, found that golimumab significantly improved active psoriatic arthritis and associated skin and nail psoriasis. The study was published in the April issue of Arthritis & Rheumatism (http://www3.interscience.wiley.com/journal/76509746/home).

Led by Arthur Kavanaugh of the University of California San Diego in La Jolla, CA the study involved 405 patients with active psoriatic arthritis even after having taken disease-modifying antirheumatic drugs or nonsteroidal anti-inflammatory drugs. Patients were randomized to receive subcutaneous injections of placebo, golimumab 50 mg, or golimumab 100 mg every four weeks for 24 weeks. Patients with less than 10 percent improvement in swollen and tender joints at week 16 were switched from placebo to 50 mg golimumab or from 50 mg to 100 mg. The primary end point of the study was the proportion of patients who met the American College of Rheumatology 20 percent improvement criteria (ACR20 response) at week 14. This response included at least a 20 percent improvement in swollen and tender joint counts and other measures such as pain, disease activity, physical function, and C-reactive protein. ACR50 and ACR70 responses were defined by at least
'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. U study shows MRI-based method holds promise for predicting treatment outcomes in patients with AF
2. Photos: Report Shows Youth Health Educators Reach More Poor Teens with a Message of Living Healthy Lives!
3. Motorola Study Shows 80 Percent of Global Healthcare IT Executives Placing Increased Reliance on Mobility
4. Sexual behavior at work still a problem shows new study from U of Ts Rotman School
5. DDB Worldwide and M/A/R/C Research Find in Time of Economic Crisis: Health Is the New Wealth, Survey Shows Empowering Patients Is Key to Influence
6. New Survey Shows School Kids 'Wagging' Breakfast Are Missing Healthy Brain Fuel
7. Biological Product Shows Promise Against Gum Disease
8. S-Shaped Light Display on Blue Cross Blue Shield of Michigan Building Shows Support for MSU Spartans
9. Survey Shows Nearly 40 Percent of Americans Reel From Heel Pain
10. Corticon Shows Business Transformation Potential of Dialogs, The First Intelligent Interactions Platform, at April 23 Webinar
11. New research shows lower educational outcomes for survivors of childhood cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Maintaining its commitment to improving life ... Campaign. Kicking off in the spirit of Better Sleep ... for everyone and to providing a therapeutic sleep experience, ... May is Better Sleep Month, a result of the ... due to the Centers for Disease Control’s confirmation that ...
(Date:5/23/2013)... To kick off barbecue season, fire up the grill this ... with simple tips from Retrofit weight loss . Keep ... , “The powerful heat of the grill can be one ... not mindful of your selections, it can be as bad ... Margulies. , Margulies advises clients to choose healthy options from ...
(Date:5/23/2013)... May 23, 2013 Retül University ... proud to announce the formation of a strategic educational ... Technologies to offer a bike industry first “Positioned ... aerodynamic assessment for time trial, road and triathlon bike ... offered to bike fitters with a Retül University, F.I.S.T. ...
(Date:5/23/2013)... to moderate iodine deficiency during pregnancy may have a ... report. Low levels of the so-called "trace element" ... child at risk of poorer verbal and reading skills ... women can boost their iodine levels by eating enough ... finding, published online May 22 in The Lancet ...
(Date:5/23/2013)... of support for war influences soldier PTSD , ... heightened risk for developing post-traumatic stress disorder if public ... recent research. Social validation or invalidation shapes the level ... the researchers say. The study involved two experiments that ... grinder in one, having an actor show either ...
Breaking Medicine News(10 mins):Health News:DUXIANA®, Quality Bed Innovator, Celebrates Better Sleep Month and Launches Summer Health Campaign 2Health News:Fire It Up! Master Calories at the Grill with Retrofit Weight Loss 2Health News:Fire It Up! Master Calories at the Grill with Retrofit Weight Loss 3Health News:Retül, Ero Sports and Alphamantis Partner for Industry First Aero Fit Course 2Health News:Retül, Ero Sports and Alphamantis Partner for Industry First Aero Fit Course 3Health News:Low Prenatal Iodine May Affect Child's Brain Development 2Health News:Link between war support and PTSD, time it late in negotiations and courtship by narcissists 2Health News:Link between war support and PTSD, time it late in negotiations and courtship by narcissists 3
... could expose people to serious risks of injury and even death ... ,As lung cancer is the leading cause of cancer deaths among ... could save lives. But a study in New York seems to ... ,Dr. Peter B. Bach, a lung specialist and epidemiologist, who ...
... the number of amyloid plaques in the brains of ... like Alzheimer's. ,Roderic Eckenhoff, MD, Vice Chair ... Anesthesia and Critical Care, and his co-authors, report their ... of Aging. ,Every year over 100 million ...
... grow a genetically modified (GM) variety of rice from ... company behind the proposal, Ventria Bioscience, says the plants ... in infants. ,These plants, incorporating human genes ... some 3,000 acres (1,215 hectares) of farmland in the ...
... intake of soy isoflavones significantly reduced the risk of prostate ... cent//, says a new study. ,"To our knowledge, ... association between isoflavone and localized prostate cancer in Japanese, whose ... Kurahashi from Japan's National Cancer Center. ,Over half ...
... food industry representatives in Sydney has come out with the ... The move follows similar ones followed overseas by other food ... under pressure from the federal government to deal with the ... of trans fats in foods ,to be spelled out on ...
... faster than the current laboratory based detection, which may ... ,Sheila MacNeil and researchers at Sheffield University have ... bacteria in less then a minute by using light, ... ,The technology could have wide applications in wound healing, ...
Cached Medicine News:Health News:CT Scans may Not Benefit Lung Cancer Patients 2Health News:Inhaled Anesthetics Accelerate the Onset of Neurodegenerative Diseases Like Alzheimer's 2Health News:Soy Isoflavones Linked to Lower Prostate Cancer Risk 2
(Date:5/23/2013)... 23, 2013  BioElectronics Corporation (OTC Pink: BIEL), the ... on the FDA panel meeting for non-thermal shortwave diathermy: ... Pulsed Shortwave Therapy Meeting was held on May 21, ... The focus of the meeting was very narrow, in ... solely on the application of non-thermal shortwave diathermy for ...
(Date:5/23/2013)... , May 23, 2013  Intercept Pharmaceuticals, Inc. (Nasdaq: ... company focused on the development and commercialization of novel ... as primary biliary cirrhosis, today announced that ... Officer, will present at the Deutsche Bank Securities 38th ... on Wednesday, May 29, 2013 at 4:10 p.m. ...
(Date:5/23/2013)...  Inhibikase Therapeutics, Inc., an emerging leader in ... present new results on its antiviral program to ... the PML Consortium (composed of Pfizer, Bristol-Meyers Squibb, ... the causative agent of Progressive Multifocal Leukoencephalopathy (PML). ... extended release formulation, can clear JC polyomavirus (JCV) ...
Breaking Medicine Technology:BioElectronics and Pulsed Shortwave Therapy Make Progress 2Inhibikase Therapeutics to present at Industry Conference on Drug-Induced Progressive Multifocal Leukoencephalopathy (PML) 2
... Oct. 7 Nile Therapeutics, Inc. (Nasdaq: ... of novel therapeutics for cardiovascular disease, today announced that ... Advisory Board overseeing the development of CD-NP, a dual ... of acute decompensated heart failure. Dr. ...
... Reportlinker.com announces that a new market research report ... RIS/PACS Market http://www.reportlinker.com/p0306627/European-RIS/PACS-Market.html ... terms of the challenges faced by market participants, drivers ... the research service include an executive summary, overview of ...
Cached Medicine Technology:Michael R. Bristow, M.D. Ph.D. Joins Nile Therapeutics Scientific Advisory Board 2Michael R. Bristow, M.D. Ph.D. Joins Nile Therapeutics Scientific Advisory Board 3Reportlinker Adds European RIS/PACS Market 2Reportlinker Adds European RIS/PACS Market 3
... are constructed of a patented ... polyvinyl acetal sponge. Each device ... to both surgeon and patient, ... firm enough to gently manipulate ...
... KeraCel Ophthalmic Products are constructed ... of lint-free MEROCEL polyvinyl acetal ... to be beneficial to both ... absorbent, and yet firm enough ...
... Ophthalmic Products provide the ... free products for unparalleled ... cleaning of fine microsurgical ... material is highly absorbent, ...
... Merocel Ophthalmic Products provide ... fiber free products for ... safe cleaning of fine ... Merocel material is highly ...
Medicine Products: