Navigation Links
New drug shows promise for those with clotting disorders: McMaster researcher
Date:12/6/2009

Hamilton, ON. Dec. 6, 2009 A new study provides welcome news for patients with a common clotting disorder known as venous thromboembolism (VTE).

The condition is estimated to impact 62,000 Canadians and half-a-million Americans every year, and occurs when an abnormal clot forms in a vein and restricts the flow of blood, causing pain and swelling. In some cases, the clot may detach from its point of origin and travel through the heart to the lungs, causing a potentially fatal condition known as a pulmonary embolism.

Currently, patients with VTE are treated with a blood thinner known as warfarin, which has many burdensome interactions with other medications and foods and requires frequent monitoring of the dosage.

However, this study published today shows that an oral drug called dabigatran etexilate, which does not have these disadvantages, is as safe and effective as warfarin for combating VTE.

To compare the two drugs, an international team of researchers lead by Sam Schulman, a professor of medicine of the Michael G. DeGroote School of Medicine, who conducted a randomized, double-blind trial of 2,539 patients with acute VTE.

Today, Schulman is scheduled to present this study to the annual conference of the American Society of Hematology in New Orleans, LA, and the New England Journal of Medicine will post the study on its web site. The study will be published in the Dec. 10 edition of the New England Journal of Medicine.

For six months, roughly half of the patients in the trial (1,274) were given a fixed dose of 150 mg of dabigatran etexilate twice daily, while the other half (1,265 patients) were given warfarin once daily.

The improvement seen in both groups from the treatments was similar. After six months of treatment, only 2.4 percent of the dabigatran etexilate group (30 patients) and 2.1 percent of the warfarin group (27 patients) experienced recurrent VTE.

The safety of the two drugs was also comparable. In the dabigatran etexilate arm, 205 patients experienced bleeding (including 20 patients with major bleeding) versus 277 patients in the warfarin arm (including 24 with major bleeding). Other possible side effects, including death, acute coronary syndromes, and abnormalities in liver function tests, were infrequent in the two groups.

"We are excited by these findings and feel that they will change the standard of care for venous thromboembolism, which affects a large number of our patients," said Schulman, a physician with the thrombosis service of Hamilton Health Sciences. "This study found that dabigatran is a safe and effective anticoagulant that does not require the routine monitoring or dose adjustments that are necessary with warfarin. In other words, patients can receive the same results in a more convenient manner."


'/>"/>

Contact: Susan Emigh
emighs@mcmaster.ca
905-518-3642
McMaster University
Source:Eurekalert

Related medicine news :

1. Congress Has Allowed Most Previous Medicare Cuts to Take Effect, New Study Shows
2. NYU Langone Medical Center Study Shows VNS Therapy is a Safe and Effective Treatment for Refractory Epilepsy
3. New Actuarial Analysis Shows Senate Bill Would Significantly Raise Premiums
4. New Hepatitis C Treatment Shows Promise
5. Report shows CIMT may improve arm use in children with hemiplegic cerebral palsy
6. Alcohol companies target youths with magazine ads, new study shows
7. Study shows modest improvement in advanced lung cancer overall survival rates
8. New Survey Shows Overwhelming Support Among Latinos for Health Care Reform That Includes Public Option
9. Brain scan study shows cocaine abusers can control cravings
10. Study shows new brain connections form rapidly during motor learning
11. Diabetes Population to Double, Diabetes Costs to Nearly Triple, in 25 Years, New Study Shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... ... today announced the official relaunch of its community and education hub for women ... Eggsurance's mission is to create a safe and welcoming place for women to ...
(Date:5/24/2016)... ... May 24, 2016 , ... The Radiosurgery Society (RSS), ... radiosurgery, is recognizing five medical residents and students for their outstanding contributions to ... The awards will be presented at the 2016 SRS/SBRT Scientific Meeting taking place ...
(Date:5/24/2016)... ... May 24, 2016 , ... The number of health ... or 10% over last year, according to data in the forthcoming AIS’s Directory ... comparatively stable, with a slight decrease in risk-based groups and a slight increase ...
(Date:5/24/2016)... ... May 24, 2016 , ... Bio-Logic Aqua® Research Water ... years and a trainer for Ageless Grace ( http://www.agelessgrace.com ) to discuss healthier ... May 16, 2016. , Formerly a Northwestern University Literature Professor, Kinst gravitated to ...
(Date:5/24/2016)... ... ... WaterAid launched the #perioddrama campaign to mark Menstrual Hygiene Day on May 28 ... world who do not have access to a toilet, even when they’re on their periods. ... #perioddrama. The (sometimes hilarious) results help shine a light on the awkwardness that women face ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... SAN FRANCISCO , May 23, 2016 ... expected to reach USD 5.0 billion by 2022, according ... The increasing generation of medical waste coupled with the ... healthcare industry is expected to drive the demand for ... with these devices as compared to that of the ...
(Date:5/20/2016)... 2016 The Biotech arena remains ... the industry is not far from recovering. There are ... the following four equities: Anacor Pharmaceuticals Inc. (NASDAQ: ... ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ), ... Sign up for your free trading alerts on these ...
(Date:5/19/2016)... Calif. , May 19, 2016  According ... thirds of the world lacks basic diagnostic imaging. ... in the United States , ... to such technology. In fact, the WHO reports ... risk of avoidable or treatable death, simply due ...
Breaking Medicine Technology: