Navigation Links
New drug shows potential for treatment-resistant leukemia
Date:4/11/2011

BOSTON (April 11) --A study from Tufts Medical Center researchers published today finds that a novel drug shows promise for treating leukemia patients who have few other options because their disease has developed resistance to standard treatment.

Appearing in the journal Cancer Cell, the study is the first published report showing that the drug, DCC-2036, fights chronic myeloid leukemia (CML) in a mouse model of the disease and is effective against human leukemia cells.

"These findings demonstrate that DCC-2036 is an excellent candidate for clinical development as a treatment for resistant CML. Not all drugs that work in a test tube will actually be effective in a living organism such as our mouse model," said Richard Van Etten, MD, PhD, Director of Tuft's Medical Center's Cancer Center and senior author of the study.

Other authors of the study are scientists with Deciphera Pharmaceuticals LLC of Lawrence, Kansas, and Emerald Biostructures of Bainbridge Island, WA.

DCC-2036 is a tyrosine kinase inhibitor (TKI), a class of drugs that block the action of an abnormal enzyme, BCR-ABL1, that sends chemical messenges that tell CML cells to grow. The development of TKI drugs such as imatinib (Gleevec) dramatically improved the prognosis for patients with CML, which strikes about 5,000 new patients each year in the United States. But about a third of patients will eventually relapse, principally because of mutations that render BCR-ABL1 resistant to the TKI. Such patients are left with few treatment options other than bone marrow transplantation.

The study showed that in human cells taken from treatment-resistant patients who had received the new drug, DCC-2036 tamped down the mutant enzyme that led to their relapse. The study also found that the drug killed malignant cells and prolonged survival in a mouse model of CML developed by Van Etten's team.

Deciphera Pharmaceuticals, LLC used crystal structures of BCR-ABL1 to custom-desig
'/>"/>

Contact: Julie Jette
jjette@tuftsmedicalcenter.org
617-636-3265
Tufts Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Brain Tumor Vaccine Shows Promise in Early Trials
2. Warning labels better than a fat tax, University of Alberta study shows
3. Unemployment Plays Role in Early Deaths, Research Shows
4. Research shows blood protein levels may predict risk of a cardiovascular event: Study
5. Long-term study shows that kidney transplants are faring better than previously reported
6. New drug shrinks cancer in animals, U-M study shows
7. Simple chemical cocktail shows first promise for limb re-growth in mammals
8. Elevated levels of sodium blunt response to stress, study shows
9. Study shows that modern surgery for scoliosis has good long-term outcomes
10. Minimally Invasive Heart-Valve Procedure Shows Promise: Study
11. PegIFN-lambda shows superior virological response and improved safety than PegIFN-alpha-2a
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... ... , ... Olive Fertility Centre is proud to announce that Olive medical director ... of the department of Family Practice. , “This award is a real honour,” says ... technology is changing so rapidly and we are also developing new models of patient-centred ...
(Date:7/6/2015)... , ... July 06, 2015 , ... ... in southern California, has partnered with Woodbridge Walk-In Urgent Care to offer on-site ... and other serious medical conditions. Screenings are affordable and accurate and run about ...
(Date:7/6/2015)... ... ... Health care systems and genomics projects have generated massive patient data sets ... this “Big Data” to improve health and cut costs is now on the horizon, ... Health System in New York City. Physicians will have these new capabilities within two ...
(Date:7/6/2015)... ... July 06, 2015 , ... In a split second, breaking a bone can ... of having a fracture through the bone health screenings conducted by American Bone Health ... participating because our residents need this information to remain independent and strong for many ...
(Date:7/6/2015)... Los Angeles, CA (PRWEB) , ... July 06, 2015 , ... ... now offering patients the opportunity to achieve their ideal appearance through comprehensive treatment solutions. ... discuss their goals with the doctor and receive a plan that resolves each of ...
Breaking Medicine News(10 mins):Health News:Olive Fertility Centre Physician Honoured for Teaching 2Health News:Woodbridge Walk-In Offers Affordable Early Detection Health Screenings Through Longevity 2Health News:Mount Sinai CEO Kenneth L. Davis, MD: Our Ability to Access Information in Real Time to Prevent Disease is Drawing Closer 2Health News:Mount Sinai CEO Kenneth L. Davis, MD: Our Ability to Access Information in Real Time to Prevent Disease is Drawing Closer 3Health News:Mount Sinai CEO Kenneth L. Davis, MD: Our Ability to Access Information in Real Time to Prevent Disease is Drawing Closer 4Health News:Mount Sinai CEO Kenneth L. Davis, MD: Our Ability to Access Information in Real Time to Prevent Disease is Drawing Closer 5Health News:National Bone Health Screening and Awareness Day 2Health News:Los Angeles Plastic Surgeon, Dr. Paul Nassif, is Now Offering Comprehensive Facial Plastic Surgery Procedures 2
... Diagnostic X-rays may increase the risk of developing ... at the University of California, Berkeley,s School of Public ... with acute lymphoid leukemia (ALL) had almost twice the ... X-rays compared with children who did not have leukemia. ...
... Burton, MD, FAAP, will serve as the 2010-2011 president ... Oct. 4, at the AAP National Conference and Exhibition ... AAP is the nation,s largest pediatric organization with a ... and pediatric surgical specialists. Dr. Burton will ...
... Studies have shown a high rate of depression among ... if any. To address this issue, researchers at Rhode ... depression care protocol in home health care. The early ... the 29th Annual Meeting and Exposition of the National ...
... FRANCISCO The stresses of poverty have long been ... presented Sunday, Oct. 3, at the American Academy of ... researchers directly linked an increased unemployment rate to child ... statistics from the Bureau of Labor Statistics, and compared ...
... , FRIDAY, Oct. 1 (HealthDay News) -- ,In yet another ... healthy for the heart. The current research found that when ... of sudden cardiac death dropped by 36 percent. However, when ... day, they upped their risk of sudden cardiac death by about ...
... a mid-sized hospital were able to increase productivity and ... general technologist productivity, according to a study in the ... of Radiology ( www.jacr.org ). "Improving productivity ... may be difficult to achieve simultaneously," said C. Daniel ...
Cached Medicine News:Health News:X-rays linked to increased childhood leukemia risk 2Health News:X-rays linked to increased childhood leukemia risk 3Health News:X-rays linked to increased childhood leukemia risk 4Health News:O. Marion Burton, M.D., F.A.A.P., addresses American Academy of Pediatrics in new term as president 2Health News:Can telemedicine improve geriatric depression? 2Health News:Moderate Alcohol Use Helps Prevent Sudden Cardiac Death: Study 2Health News:Moderate Alcohol Use Helps Prevent Sudden Cardiac Death: Study 3
(Date:7/6/2015)... July 6, 2015 Mauna ... the multidisciplinary confocal laser endomicroscopy platform, announced today ... Ministry of Health, Labor and Welfare ... solution, the AQ-Flex 19 miniprobe.   ... 19 miniprobe is comprised of a fiber-optic microscope ...
(Date:7/6/2015)... , July 6, 2015  Protiviti, a global consulting ... Internal Auditing around the World publication ( www.protiviti.com/iaworld ... and reported on the evolution of the internal audit ... the globe as a means to providing senior executives ... this strategic business function. The 2015 edition ...
(Date:7/6/2015)... June 29, 2015 Research ... the "Pharmaceutical Grade Sodium Chloride Market by Applications, ... report to their offering. The pharmaceutical ... CAGR of 6.9% between 2014 and 2019 in terms ... 690 KT by 2019. The report on ...
Breaking Medicine Technology:Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 2Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 3New Edition of Internal Auditing Around the World from Protiviti Explores Changes and Trends 2Global Pharmaceutical Grade Sodium Chloride Market Report 2015 2Global Pharmaceutical Grade Sodium Chloride Market Report 2015 3
... N.J., May 16, 2011 New Jersey Center for ... in the nation to treat advanced prostate cancer patients ... class known as autologous cellular immunotherapies.  PROVENGE was approved ... the treatment of men with asymptomatic or minimally symptomatic ...
... public health, and regulatory highlights for this week from the ... designed for credentialed journalists. Release dates and times for items ... (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ) FDA News & Notes ... legal limitations. Events and Speeches for ...
Cached Medicine Technology:New Jersey Center for Prostate Cancer & Urology Among First in Nation to Treat Advanced Prostate Cancer Patients with PROVENGE 2FDA News & Notes - Week of May 16, 2011 2FDA News & Notes - Week of May 16, 2011 3
... to quality patient care., ,S/5 Anesthesia ... to anesthesia delivery. As part of the ... features, electronically controlled gas delivery and agent ... to create a truly integrated system. The ...
... Tegagel hydrogel wound filler and ... are amorphous hydrogel dressings specially formulated ... that has been shown to enhance ... formula meets clinical needs for management ...
... SS is a complete physician preference card ... management system for all the supply management ... preference card system combined with a broad ... entire case cart and operating suite supply ...
Easy to Use manual vacuum system features a pumping mechanism that can be operated with one hand....
Medicine Products: