Navigation Links
New drug screening identifies chemical agents with potent anti-cancer activity
Date:1/5/2012

Drugs already approved for clinical use across a variety of therapeutic categories can be screened to identify effective agents for thyroid cancer according to a recent study accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). These findings could rapidly be implemented into a clinical trial to test how effective the treatment would be.

The discovery of new chemical agents capable of modulating a disease is a long and expensive process. An alternative approach that is just beginning to be explored is the potential repurposing of already established drugs which have been approved for clinical use. The current study examined the newly assembled National Institutes of Health (NIH) Chemical Genomic Center's pharmaceutical collection, which contains 2,816 approved drugs and bioactive compounds and sought to identify agents with an anti-cancer effect in thyroid cancer cell lines.

"To our knowledge, this is the first study to use such a large collection of clinical drugs to test anti-proliferative effect in cancer cells," said Electron Kebebew, MD, of the National Cancer Institute in Bethesda, MD and lead author of the study. "The compounds found to have potent activity in our screen represent possible opportunities to repurpose these drugs for the treatment of patients with aggressive recurrent or metastatic thyroid cancer."

In this study, researchers used a quantitative high-throughput screening (qHTS) approach to examine the effect of 2,816 clinically approved drugs on thyroid cancer cells. qHTS is a titration-based screening paradigm where compounds are screened at multiple concentrations. By employing this approach, researchers found numerous agents across different therapeutic categories and mode of action that had an anti-cancer effect.

"Clinicians can more readily translate these findings into therapy when the drug characteristics are well-known. The drugs can then be used in developing clinical trials or in some cases for off-label use," said Kebebew. "Furthermore, qHTS could be used for identifying therapeutics not only for cancer, but for many other diseases."


'/>"/>
Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Self-affirmation may break down resistance to medical screening
2. Screening Alone Not Enough to Prevent Sudden Death in College Athletes
3. Making Sense of Cancer Screening Updates
4. IASLC sets up committee to move CT lung cancer strategic screening forward
5. American Cancer Society revises cancer screening guideline process
6. Biopsy referral after PSA screening stays consistent over time
7. NCAA mandatory sickle cell screening program not enough to save athletes lives
8. British Screening Program Finding More Early Stage Colon Cancers
9. Mammography screening reduced risk for death from breast cancer by half
10. Targeted Drugs, Lung CT Screening Top Cancer Advances in 2011
11. Studies of patients with cirrhosis uncover limitations in liver cancer screening
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... ... from across the country gathered at the La Valencia Hotel in San Diego, ... PROSHRED Chicago was named the year’s most outstanding franchise, walking away with the ...
(Date:2/5/2016)... ... , ... Give To Cure today announced that it is working ... To Cure’s campaign that is crowdfunding clinical trials to help find cures faster for ... a smart device. In 2015 alone, Venmo processed $7.5 billion in transactions among users. ...
(Date:2/5/2016)... New York, New York (PRWEB) , ... February 05, 2016 , ... ... (APDA) announced the election of Patrick McDermott as Chairman of the National Board of ... welcome Pat as Chairman of the Board,” stated Leslie A. Chambers , APDA ...
(Date:2/5/2016)... ... February 05, 2016 , ... Dr. Ben Amini, ... it is now welcoming orthodontist, Dr. Amanda Cheng, to the practice. With the ... oral health care, including general dentistry, cosmetic treatments, periodontics, implant dentistry , ...
(Date:2/5/2016)... ... February 05, 2016 , ... Health and wellness is a topic that ... the event they are experiencing an illness. Migraines are a severe form of a ... with migraines would not wish the pain on their worst enemy, the feeling can ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... -- Worldwide Radiology Oncology surgical robot markets are ... systems provide a way to improve traditional open ... systems pinpoint the delivery of radiation precisely, eliminating ... problem previously, limiting the quantity of radiation that ... far beyond what has been available, promising a ...
(Date:2/4/2016)... 4, 2016  SciClone Pharmaceuticals, Inc. (NASDAQ: ... entered into a settlement agreement with the United ... the SEC,s investigation into possible violations of the ... of the settlement agreement, SciClone has agreed to ... pre-judgment interest and a penalty.  This payment is ...
(Date:2/4/2016)... , Feb. 4, 2016  Montoya Love is recognized ... the field of Pharmaceuticals. Montoya is the Regulatory Systems ... Manufacturing and selling ... Becton Dickinson provides healthcare institutions, clinical laboratories and ... fifty countries across the globe. ...
Breaking Medicine Technology: