Navigation Links
New drug screening identifies chemical agents with potent anti-cancer activity
Date:1/5/2012

Drugs already approved for clinical use across a variety of therapeutic categories can be screened to identify effective agents for thyroid cancer according to a recent study accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). These findings could rapidly be implemented into a clinical trial to test how effective the treatment would be.

The discovery of new chemical agents capable of modulating a disease is a long and expensive process. An alternative approach that is just beginning to be explored is the potential repurposing of already established drugs which have been approved for clinical use. The current study examined the newly assembled National Institutes of Health (NIH) Chemical Genomic Center's pharmaceutical collection, which contains 2,816 approved drugs and bioactive compounds and sought to identify agents with an anti-cancer effect in thyroid cancer cell lines.

"To our knowledge, this is the first study to use such a large collection of clinical drugs to test anti-proliferative effect in cancer cells," said Electron Kebebew, MD, of the National Cancer Institute in Bethesda, MD and lead author of the study. "The compounds found to have potent activity in our screen represent possible opportunities to repurpose these drugs for the treatment of patients with aggressive recurrent or metastatic thyroid cancer."

In this study, researchers used a quantitative high-throughput screening (qHTS) approach to examine the effect of 2,816 clinically approved drugs on thyroid cancer cells. qHTS is a titration-based screening paradigm where compounds are screened at multiple concentrations. By employing this approach, researchers found numerous agents across different therapeutic categories and mode of action that had an anti-cancer effect.

"Clinicians can more readily translate these findings into therapy when the drug characteristics are well-known. The drugs
'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Self-affirmation may break down resistance to medical screening
2. Screening Alone Not Enough to Prevent Sudden Death in College Athletes
3. Making Sense of Cancer Screening Updates
4. IASLC sets up committee to move CT lung cancer strategic screening forward
5. American Cancer Society revises cancer screening guideline process
6. Biopsy referral after PSA screening stays consistent over time
7. NCAA mandatory sickle cell screening program not enough to save athletes lives
8. British Screening Program Finding More Early Stage Colon Cancers
9. Mammography screening reduced risk for death from breast cancer by half
10. Targeted Drugs, Lung CT Screening Top Cancer Advances in 2011
11. Studies of patients with cirrhosis uncover limitations in liver cancer screening
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... Recently, 2014QuinceaneraDresses.com, the distinguished special ... new range of gorgeous Quinceanera dresses . ... for elegant Quinceanera outfits is huge. Therefore, 2014QuinceaneraDresses.com ... the company’s newly released dresses are made according ... elegant and vivid. , It is worthy ...
(Date:7/13/2014)... imaging device developed at Cedars-Sinai can provide early ... brain and are a classic sign of Alzheimer,s ... a clinical trial in Australia. , The researchers ... oral presentation at the Alzheimer,s Association International Conference ... by conference organizers to participate in a "breaking ...
(Date:7/13/2014)... 2014 Celebrity fitness trainer and former ... promotional partnership with Aqua Health Labs for their flagship ... supplement . The collaboration was recently announced live on ... trainer , actor, model, and a two time World ... celebrities, he has prepared stars including Demi Moore, Hilary ...
(Date:7/13/2014)... Seattle, Wa (PRWEB) July 13, 2014 ... updated by Vkool.com, this is a comprehensive guide that ... to deal with KP (keratosis pilaris). This ...     Chapter 1: What Is Keratosis Pilaris? ,     Chapter ... Do I Know If I Have KP? , ...
(Date:7/12/2014)... July 12, 2014 The Chicken ... the past five years, buoyed by stable demand for ... management system. “Eggs are a relatively affordable staple for ... egg consumption generally grows in line with the size ... McKitterick. Furthermore, demand for new specialty egg products with ...
Breaking Medicine News(10 mins):Health News:2014QuinceaneraDresses.com Releases Its New Quinceanera Dresses 2Health News:Study of noninvasive retinal imaging device presented at Alzheimer's conference 2Health News:Study of noninvasive retinal imaging device presented at Alzheimer's conference 3Health News:Celebrity Fitness Expert Supports Revolutionary New Health Supplement 2Health News:Living With KP Book Review Exposes Jennifer Richards' Keratosis Pilaris Guide – Vkool.com 2Health News:Living With KP Book Review Exposes Jennifer Richards' Keratosis Pilaris Guide – Vkool.com 3Health News:Chicken Egg Production in Canada Industry Market Research Report Now Available from IBISWorld 2Health News:Chicken Egg Production in Canada Industry Market Research Report Now Available from IBISWorld 3
... acoustic guitars to wounded guitar-playing service members as part of a ... in San Antonio, TX. , ... Pasadena, CA (PRWEB) ... will present over twenty new acoustic guitars to wounded guitar-playing service ...
... siRNA drug delivered systemically, FREMONT, Calif., June ... U.S. Food and Drug Administration (FDA) has,approved the ... drug candidate, DGFi, in kidney transplantation. The Company ... Delayed Graft,Function (DGF) in kidney transplant patients to ...
... at the Silicom Ventures Summit on June 29th-30th in Tel Aviv. ... ... Mind Ltd (SoM) was selected to present its concept and system for ... in Tel Aviv, Israel. The developed system, called SoM-ToUR, is based on ...
... condition a public health priority , , THURSDAY, June 26 ... kidney disease (CKD) is increasing, and the fact it raises ... public health priority, say Taiwanese researchers. , They analyzed data ... part in a standard medical screening program in 1994. The ...
... in the United States in recent years even though the ... by researchers at the Johns Hopkins Bloomberg School of Public ... percent among black men ages 25 to 44 and 12 ... is published in Online First edition of the Journal ...
... June 26 "The only way to flatten ... was the overriding,sentiment at last week,s I3 (insight, ... This statement made by keynote speaker,Wally Gomaa, president ... hospitals and employers must begin (or continue) working,together ...
Cached Medicine News:Health News:Freedom Celebration - Gibson Guitar to Provide Instruments for the Wounded 2Health News:Freedom Celebration - Gibson Guitar to Provide Instruments for the Wounded 3Health News:Quark Pharmaceuticals Receives FDA Approval of IND for Kidney Transplant siRNA Drug DGFi 2Health News:Quark Pharmaceuticals Receives FDA Approval of IND for Kidney Transplant siRNA Drug DGFi 3Health News:Step of Mind Ltd Will Present its Concept at the Silicom Ventures Summit 2Health News:Chronic Kidney Disease Growing Globally 2Health News:Researchers study hidden homicide trend 2Health News:Aegis Health Group Revealed Next Generation of Employer-Based Health-Improvement Strategies at Nashville Conference 2
(Date:7/10/2014)... 10, 2014   Ventana Medical Systems, Inc.  (Ventana), ... has entered into an agreement with Merck KGaA, Darmstadt, ... Serono in the United States ... Merck KGaA,s biopharmaceutical division on the development and commercialization ... using Ventana,s proprietary diagnostic assays. In alignment with Merck ...
(Date:7/10/2014)... Decision Resources Group finds that over half ... and Drug Administration,s (FDA) approval of Vifor Fresenius Medical ... approved by the FDA in November 2013 for the ... on dialysis. Other key findings from the ... : , Bundling: ...
(Date:1/15/2014)... Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced the addition of ... Size, Share, Growth, Trends And Forecast, 2013 - 2018" ... http://photos.prnewswire.com/prnh/20130307/600769 ) Dental consumables ... to treat dental impairments, for tooth restoration and in ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3
... schools across the country, teachers are directed to send students ... have a vision issue.  This could be due to the ... the blackboard, poor performance in class or disruptive behavior. The ... difficult and that student could end up in the principal,s ...
... largest professional network for physicians, announced today ... power their medical expert searches. These firms are the ... million in honoraria to physicians last year. Using Doximity,s ... of over 30,000 physician experts. For physicians,  ...
Cached Medicine Technology:Disruptive Students May Not Be Able to See Their Problem 2Disruptive Students May Not Be Able to See Their Problem 3Disruptive Students May Not Be Able to See Their Problem 4Doximity Launches ExpertFinder to Match Clinical Need with Clinical Experts 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: