Navigation Links
New drug reduces tumor size in women with advanced hereditary ovarian or breast cancer
Date:8/12/2010

LOS ANGELES (Aug. 11, 2010) Understanding the underlying genetic weakness of certain types of cancer may lead to targeted therapy and provide the key to effective treatment, a new study suggests. An international consortium of researchers has shown that an investigational drug, Olaparib, can reduce the size of tumors in women with advanced hereditary ovarian cancer with BRCA gene mutations.

The Phase II ovarian cancer study results as well as another Phase II trial in which Cedars-Sinai researchers also participated that evaluated the drug's effectiveness in the treatment of hereditary breast cancer were published in a recent issue of Lancet. The two trials showed similar levels of response to the genetically-targeted drug in both breast and ovarian cancers with BRCA mutations.

"These are significant new studies. Olaparib is the first single-agent, non-chemotherapy treatment to show benefit to patients with cancers that result from BRCA1 or BRCA2 gene mutations," said William Audeh, M.D., an oncologist specializing in cancer genetics at Cedars-Sinai's Samuel Oschin Comprehensive Cancer Institute and first author on the ovarian cancer study "Until now, treatments for cancer have been selected based upon where in the body the cancer originated. These two studies suggest that it is the underlying genetic weakness of a cancer, not the organ of origin, that is the key to selecting effective therapy."

The first author of the breast cancer study and the principal investigator for both studies was Andrew Tutt, M.D., Breakthrough Breast Cancer Research Unit, King's College London School of Medicine.

Olaparib, a Poly ADP ribose polymerase (PARP) inhibitor made by AstraZeneca, represents a "targeted therapy" approach to cancer treatment anticancer drugs that interfere with specific pathways involved in cancer growth or survival. The PARP enzyme plays a role in DNA repair, including the repair of DNA damage from che
'/>"/>

Contact: Simi Singer
simi.singer@cshs.org
310-423-7798
Cedars-Sinai Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Service Foods Reduces its Carbon Footprint and Grows Sales
2. Health Care Reform Report Covers Uninsured, Reduces Costs
3. New cardiac CT technology drastically reduces patient radiation exposure
4. Accelerated radiation therapy reduces toxicity in patients with advanced head and neck cancers
5. Targeted delivery of losartan reduces liver inflammation and scarring
6. Drug dramatically reduces nausea and vomiting in bone marrow transplant patients
7. Soccer reduces risk of falls and bone fractures
8. Pioneering treatment reduces disability in premature babies with serious brain hemorrhage
9. New drug candidate reduces blood lipids
10. PSA Test Reduces Prostate Cancer Deaths by 40%
11. New technique reduces tobacco smoke damage to lungs in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... June 19, 2013 Bonita ™ ... effective answer for years, to many conditions that range ... loss and wrinkles. Essential Source® has now developed a ... Revytalyz 5™, that is not only stronger than the ... vegetarian and vegan community. , Justin Zehrung, ...
(Date:6/19/2013)... 19, 2013 Best Halfway House is stretching ... a chance to keep on their road of recovery from ... menu of selections for sober houses for men and women. ... their network need to meet certain criteria. They have to ... houses must have structure and accountability measures in place. This ...
(Date:6/19/2013)... Semi Truck Accident Victims Center says, "If you, ... serious accident involving a semi truck, or commercial vehicle in ... we are urging you to call us for our on ... essence, and it really is vital to have a skilled ... investigators in your corner as quickly as possible, and this ...
(Date:6/19/2013)... 19, 2013 MinuteHound, a leading time ... can save businesses up to 8% on payroll costs. ... traditional time card systems. Their biometric system is simple: ... which clocks them in and out automatically. Employee ... theft and buddy punching. , Because the fingerprint ...
(Date:6/19/2013)... 2013 National Camp Series (NCS) ... For The Dream’s effort to fight ovarian cancer according to ... , "We are excited to have Dan jump on board,” ... for young specialists; great example, great purpose. That is exactly ... , Zeidman says Kicking For The Dream is ...
Breaking Medicine News(10 mins):Health News:Essential Source ® Improves On Best Selling Bonita ™ Hair Skin and Nail Product 2Health News:Pensacola, Florida Joins Best Halfway House Recovery Network, Providing Resources for Those Seeking to Further Their Recovery from Drug and Alcohol Addiction 2Health News:The Semi Truck Accident Victims Center Urges Families Of Innocent Victims Of A Semi Truck Accident In Montana, Idaho Or Wyoming To Call Them For An On The Spot Response 2Health News:MinuteHound Announces How Cloud Computing Technology Boosts Savings 2Health News:MinuteHound Announces How Cloud Computing Technology Boosts Savings 3Health News:National Camp Series (NCS) Associate Dan Zeidman of Lifetime Kicking Academy Joins Kicking For The Dream’s Effort to Fight Ovarian Cancer 2Health News:National Camp Series (NCS) Associate Dan Zeidman of Lifetime Kicking Academy Joins Kicking For The Dream’s Effort to Fight Ovarian Cancer 3
... rural women, it,s cheaper and less time-consuming than ... News) -- Telephone counseling may be as effective as ... report. , The University of Florida study included 234 ... areas of northern Florida. , All the women completed ...
... regulate appetite , , WEDNESDAY, Nov. 26 (HealthDay News) -- As ... year, a molecule produced in the small intestine will be ... the impact of the fat you,ve just consumed. , For ... while. But, researchers are hoping that one day variations of ...
... breast tissue, cells lining the breast,s ducts have a ... structure and function. All breast cancers display a loss ... about the molecules and pathways that regulate tissue structure ... A team of scientists at Cold Spring Harbor Laboratory ...
... of rats to sweet foods and drives them to ... from the Penn State study could uncover a critical ... flab hooks the brain on sugary food., "When you ... to consume it in higher amounts," said Andras Hajnal, ...
... LWAY ), makers of a nutritious, probiotic dairy ... new share repurchase,program of up to 100,000 shares. Under ... of the Company,s Common Stock through the open,market within a ... purchase. The,Company will use its available cash resources to ...
... Billion Dollar Increase in Value of Family Members Taking Care of ... CHICAGO,Nov. 26 With the economy continuing it,s downward turn, family ... in need. A new AARP report found the value of ... a $1 billion increase since 2006. While nearly 1.5 million ...
Cached Medicine News:Health News:Over-the-Phone Weight Loss Counseling Works 2Health News:Fat-Sensing Hormones Might Fight Obesity 2Health News:CSHL scientists show how a protein that determines cell polarity prevents breast cancer 2Health News:CSHL scientists show how a protein that determines cell polarity prevents breast cancer 3Health News:Route to obesity passes through tongue 2Health News:Route to obesity passes through tongue 3Health News:Lifeway Foods Announces New 100,000 Share Buyback Program 2Health News:AARP Finds Value of Unpaid Family Caregiving in Illinois Hits $17 Billion 2
(Date:6/18/2013)... GARDEN CITY, N.Y. , June 18, 2013 ... announced that it has entered into an exclusive ... and Mid-Atlantic regions with eWellness Corporation ("EWC") for ... "An easy to use physical therapy program ... of diabetes and cardiovascular disease," said Chris ...
(Date:6/18/2013)... 18, 2013  Women are frequently the healthcare advocate ... often do not give the same priority to their ... from their doctor because they were too embarrassed or ... recent survey conducted by Allergan and endorsed by the ... education, funding and research to the field of women,s ...
(Date:6/18/2013)... Decision Resources, one of the world,s leading research and advisory ... past 12 months, 25 percent of surveyed physicians from the ... , Italy , Spain ... been required to change the antiretroviral (ARV) prescription for some ... Additionally, more than 40 percent of respondents report that changing ...
Breaking Medicine Technology:Millennium HealthCare Signs Exclusive Distribution Agreement with eWellness Corporation for Northeast and Mid-Atlantic Regions 2Millennium HealthCare Signs Exclusive Distribution Agreement with eWellness Corporation for Northeast and Mid-Atlantic Regions 3New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 2New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 3New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 4New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 5New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 6New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 7New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 8New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 9One in Four Surveyed EU5 Physicians Has Been Required to Change a Prescription for Some or Most of Their HIV Patients in the Past Twelve Months, Primarily to Reduce Costs 2One in Four Surveyed EU5 Physicians Has Been Required to Change a Prescription for Some or Most of Their HIV Patients in the Past Twelve Months, Primarily to Reduce Costs 3
... obesity and,complications arising from popular aesthetic surgical procedure, ... study,investigating the relationship between complications of body contouring,surgery ... in the occurrence of,such complications with worsening degree ... the July/August 2008 issue of the Aesthetic Surgery,Journal, ...
... MOORESVILLE, N.C., July 30 Anpath Group, Inc.,(OTC ... owned,subsidiary, EnviroSystems, Inc. (ESI) announced that its EnviroTru(R),disinfectant ... Department of,Management Services (DMS) in the State of ... of Green, LLC(TM) ( http://www.aworldofgreen.com ),worked ...
Cached Medicine Technology:Body Contouring Surgery Risk Rises with Increased Body Mass Index 2Body Contouring Surgery Risk Rises with Increased Body Mass Index 3Anpath Group, Inc. Announces Approval of its Disinfectant by the State of Florida 2Anpath Group, Inc. Announces Approval of its Disinfectant by the State of Florida 3
... result of DEKA s new technology ... different methods capable of restoring a ... treatment is designed to dramatically reduce ... combined action of a localized cooling ...
... its great versatility in epilation and ... the compactness and easy-transportability of the ... protocols developed for Smartepil II plus, ... indicated for hair removal of tricky ...
... new and efficient method applied to dermatological ... ongoing research and development with hundreds of ... light source, but rather a platform for ... horizons in pulsed-light-based technology, the most valid ...
Auto Refkeratomoeter...
Medicine Products: