Navigation Links
New drug prevents spread of human prostate cancer cells
Date:4/3/2012

CHICAGO --- A new drug developed by Northwestern Medicine scientists prevented human prostate cancer cells from spreading to other tissues without any toxic effects to normal cells or tissues. The drug turns off the "go" switch in the cancer cells and immobilizes them.

Prostate cancer is the second-leading cause of cancer death in North American males. Death is mainly caused by metastasis, prostate cancer cells moving out of prostate tissue and spreading to other organs.

"This is an extremely promising new therapeutic that locks down aggressive prostate cancer cells so they don't move," said Raymond Bergan, M.D., director of experimental therapeutics for the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. "The spread of prostate cancer is what kills men. Cancer cells have a switch that tells them to keep moving all the time. This drug turns it off."

The drug works by binding to and disabling proteins in the cancer cell that instruct it to move, said Bergan, a professor of medicine at Northwestern's Feinberg School of Medicine and a physician at Northwestern Memorial Hospital.

The research was presented April 3 at the American Association for Cancer Research Annual Meeting 2012 in Chicago by Li Xu, a research assistant professor of medicine at the Feinberg School. She helped develop the drug, along with Karl Scheidt, an associate professor of chemistry at the Weinberg College of Arts and Sciences.

In the study, Northwestern researchers transplanted aggressive human prostate cancer cells into mice prostate tissue and fed the mice with the new drug for five weeks. The drug inhibited movement of the cells and prevented them from metastasizing to the lung, one of the tissues to which prostate cancer spreads in men.

Xu said she conducted extensive toxicity studies, including on normal human cells, and found that the drug, called KBU2046, is nontoxic and does not cause any harmful effects.

"We envision that this drug, if shown to be effective in clinical trials, could be used to treat men diagnosed with prostate cancer, so they wouldn't need more aggressive procedures," Bergan said. "Or, the drug could augment the effectiveness of surgery and radiation."

Bergan hopes to test the drug in a clinical trial.


'/>"/>
Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Related medicine news :

1. Colonoscopy prevents deaths from colon cancer
2. Dirt prevents allergy
3. Drug prevents bone loss side effects of breast cancer medication
4. Knockout of protein prevents colon tumor formation in mice
5. Marijuana administration after a traumatic experience prevents post-traumatic stress symptoms
6. Adding a stent during minimally invasive surgery to repair aneurysms prevents recurrence
7. Tai Chi Prevents Falls, Boosts Mental Health in Seniors: Study
8. UNC-led study shows early treatment with antiretroviral therapy prevents HIV transmission
9. Tobacco-derived compound prevents memory loss in Alzheimers disease mice
10. Early infusion of donor T cells prevents graft versus host disease in blood cancer patients
11. Tomatoes found to contain nutrient which prevents vascular diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... , ... February 05, 2016 , ... After years as ... Hospital Burn Unit, plastic and cosmetic surgeon Dr. Wayne Carman transitioned to chief of ... He successfully completed his first three-year term as chief and began a second three-year ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... ... independent PROSHRED franchises from across the country gathered at the La Valencia Hotel ... top performers. PROSHRED Chicago was named the year’s most outstanding franchise, walking ...
(Date:2/5/2016)... ... February 05, 2016 , ... Give To Cure today announced ... and donate to Give To Cure’s campaign that is crowdfunding clinical trials to help ... and share payments through a smart device. In 2015 alone, Venmo processed $7.5 billion ...
(Date:2/5/2016)... York, New York (PRWEB) , ... February 05, 2016 , ... ... announced the election of Patrick McDermott as Chairman of the National Board of Directors. ... Pat as Chairman of the Board,” stated Leslie A. Chambers , APDA President ...
(Date:2/5/2016)... ... February 05, 2016 , ... Dr. Ben Amini, ... it is now welcoming orthodontist, Dr. Amanda Cheng, to the practice. With the ... oral health care, including general dentistry, cosmetic treatments, periodontics, implant dentistry , ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... Feb. 5, 2016  Venice,s newest laser clinic, ... first of its kind in the area and ... advanced laser treatment. The physician-owned and operated laser ... Suncoast by storm with its revitalizing skin care ... multi-wavelength Astanza Trinity technology. http://photos.prnewswire.com/prnh/20160204/329957 ...
(Date:2/5/2016)... Feb. 5, 2016  Zimmer Biomet Holdings, Inc. (NYSE ... previously announced underwritten secondary offering of 11,027,558 shares of ... of affiliates of Blackstone and Goldman Sachs.  The shares ... price of $96.45 per share. The selling stockholders will ... Zimmer Biomet nor any of its directors, officers or ...
(Date:2/5/2016)... , February 5, 2016 ... Today, VoicePower Ltd - The Speech Recognition People, announced their ... deployed to improve patient care, reduce turnaround times and to save ... CCG ,- VoicePower client since 2013 Challenge: --> ... Challenge: --> - Six doctors ,- Wirral CCG ,- ...
Breaking Medicine Technology: