Navigation Links
New drug prevents spread of human prostate cancer cells
Date:4/3/2012

CHICAGO --- A new drug developed by Northwestern Medicine scientists prevented human prostate cancer cells from spreading to other tissues without any toxic effects to normal cells or tissues. The drug turns off the "go" switch in the cancer cells and immobilizes them.

Prostate cancer is the second-leading cause of cancer death in North American males. Death is mainly caused by metastasis, prostate cancer cells moving out of prostate tissue and spreading to other organs.

"This is an extremely promising new therapeutic that locks down aggressive prostate cancer cells so they don't move," said Raymond Bergan, M.D., director of experimental therapeutics for the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. "The spread of prostate cancer is what kills men. Cancer cells have a switch that tells them to keep moving all the time. This drug turns it off."

The drug works by binding to and disabling proteins in the cancer cell that instruct it to move, said Bergan, a professor of medicine at Northwestern's Feinberg School of Medicine and a physician at Northwestern Memorial Hospital.

The research was presented April 3 at the American Association for Cancer Research Annual Meeting 2012 in Chicago by Li Xu, a research assistant professor of medicine at the Feinberg School. She helped develop the drug, along with Karl Scheidt, an associate professor of chemistry at the Weinberg College of Arts and Sciences.

In the study, Northwestern researchers transplanted aggressive human prostate cancer cells into mice prostate tissue and fed the mice with the new drug for five weeks. The drug inhibited movement of the cells and prevented them from metastasizing to the lung, one of the tissues to which prostate cancer spreads in men.

Xu said she conducted extensive toxicity studies, including on normal human cells, and found that the drug, called KBU2046, is nontoxic and does not cause any harmful effect
'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Colonoscopy prevents deaths from colon cancer
2. Dirt prevents allergy
3. Drug prevents bone loss side effects of breast cancer medication
4. Knockout of protein prevents colon tumor formation in mice
5. Marijuana administration after a traumatic experience prevents post-traumatic stress symptoms
6. Adding a stent during minimally invasive surgery to repair aneurysms prevents recurrence
7. Tai Chi Prevents Falls, Boosts Mental Health in Seniors: Study
8. UNC-led study shows early treatment with antiretroviral therapy prevents HIV transmission
9. Tobacco-derived compound prevents memory loss in Alzheimers disease mice
10. Early infusion of donor T cells prevents graft versus host disease in blood cancer patients
11. Tomatoes found to contain nutrient which prevents vascular diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... R.I. Researchers have found that fecal transplantation ... in immunocompromised patients. This is the result of ... in the Center for Women,s Gastrointestinal Medicine at The ... been published online in advance of print in the ... difficile , or C. diff , has increased ...
(Date:7/9/2014)... is available in French . ... 14 year old teens, including brain structure and function, personality, ... who will go on to develop binge drinking within the ... and other variables such as life events and a family ... drinking. Whether or not the child had had a ...
(Date:7/9/2014)... highlights, Brian Williams refreshing old school rap classics, and ... A University of Colorado Cancer Center study published in ... also allows researchers, journals, and health advocates to connect ... and prevention. , "No matter what field you,re in, ... around the world," says Chante Karimkhani, MD candidate in ...
(Date:7/9/2014)... BOSTON (July 9, 2014) A retrospective study conducted ... and colleagues reports that among adults with intellectual and ... the number of years receiving dental care increased. The ... Care in Dentistry , may help improve interventions designed ... population. , The researchers reviewed the dental records ...
(Date:7/9/2014)... A study published in the scientific journal ... Bonin, two researchers at Universit Laval, reveals that it ... method that involves rekindling pain so that it can ... means to alleviate chronic pain. , The researchers from ... universitaire en sant mentale de Qubec (IUSMQ) were inspired ...
Breaking Medicine News(10 mins):Health News:Women's Medicine Collaborative examines safety of fecal transplant to treat C. difficile 2Health News:What drives a child to abuse alcohol? 2Health News:Study of dermatology on YouTube shows new ways science reaches public 2Health News:Adults with special needs see gains, challenges with long term oral care 2Health News:Adults with special needs see gains, challenges with long term oral care 3Health News:Discovery of a new means to erase pain 2
... Over ... their subscribers and readers demand for more alkaline and organic food…, , ... (PRWEB) June 14, 2010 -- TheAlkalineDiet.org has just ... products from all over the world. Since the launch of the website in November 2009, ...
... patients who directly confronted the stress of the Second Lebanon ... with the situation by focusing on feelings. This has been ... the University of Haifa, the Technion-Israel Institute of Technology and ... sclerosis to date, it is important to uncover all the ...
... recommended A1c blood test cutoff didn,t accurately diagnose elderly ... -- Despite its endorsement last year by the American ... 2 diabetes, new research out of Singapore suggests that ... the disease among elderly Asians. , The American Diabetes ...
... ... Horizon Healthcare Services, Inc. to Put Evidence-Based Medicine into Practice with Via Oncology Pathways ... Pittsburgh ... will continue to improve as a result of wider application of Via Oncology™ Pathways, ...
... ... ,Camera to data toggle application revolutionizes any Windows Mobile Device with Camera and replaces any ... ... of the Kodak roll film camera in 1888, engineers, inspectors and professionals have used a ...
... ... The Verdin Company announced today it has acquired ... a leader in manufacturing architectural site furnishings. The Verdin Company, ... installer of clocks, bells, carillons, bell and clock towers, glockenspiels, and ...
Cached Medicine News:Health News:Official Alkaline Diet Site Launches Organic Food Store for Healthy Living And Natural Weight Loss 2Health News:Official Alkaline Diet Site Launches Organic Food Store for Healthy Living And Natural Weight Loss 3Health News:Can multiple sclerosis attacks be minimized in a war zone? 2Health News:Age, Race May Affect Type 2 Diabetes Screening Results 2Health News:Hematology-Oncology Associates of Northern New Jersey (HOANNJ) Joins Effort to Improve Cancer Care with Via Oncology™ Pathways 2Health News:Hematology-Oncology Associates of Northern New Jersey (HOANNJ) Joins Effort to Improve Cancer Care with Via Oncology™ Pathways 3Health News:Mobile and Patented: DATA-TO-CAMERA TOGGLE on handheld device replaces old camera and clipboard approach everywhere! Beats IPAD to camera punch too..... 2Health News:The Verdin Company Acquires Canterbury International, an industry leader in architectural site furnishings for over 50 years 2Health News:The Verdin Company Acquires Canterbury International, an industry leader in architectural site furnishings for over 50 years 3
(Date:1/15/2014)... LAWRENCEVILLE, N.J. , Jan. 15, 2014  Celsion Corporation (the ... it has received commitments from institutional investors to purchase ... common stock in an at-the-market registered direct offering, led ... Company entered into definitive purchase agreements with these investors ...
(Date:1/15/2014)... 2014 Shire plc (LSE: SHP, NASDAQ: ... Trading (OFT) approval condition to the announced tender offer for all ... As a result of the waiver, the transaction is no ... tender offer on January 24, 2014 following the currently scheduled expiration ...
(Date:1/15/2014)... 2014 BreedIT Corp (OTC: BRDT), through ... of highly sophisticated agro-breeding solutions for plant breeders and ... Company,s board of directors appointed chemistry and pharmaceutical industry ... member of the board. From 1975 to ...
Breaking Medicine Technology:Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3
... Reportlinker.com announces that a new market ... Vaccines - Eastern Europe ... This package contains 15 vaccine market ... Bulgaria, Czech Republic, Estonia, Greece, Hungary, Latvia, ...
... pleased to announce the signing of a reseller agreement ... Body Pro-Lok to its customers. Introduced in 2008 and ... Body Pro-Lok excels as a modular base for indexable ... (Logo: http://photos.prnewswire.com/prnh/20110419/AQ85801LOGO ) Body ...
Cached Medicine Technology:Vaccines - Eastern Europe 2Varian Medical Systems to Offer CIVCO Medical Solutions' Body Pro-Lok™ for SBRT 2
For use with cushioned neckband....
... PVC siliconized. Stainless steel spiral reinforced. X-ray ... use. Adjustable Flange: The flange can be ... the thickness of the cervical soft tissue. ... the flange is tightly connected to the ...
... The permanent flexible tube ... of the neck flange helps ... neck, chin, and stoma, enhancing ... ,Bivona® FlexTend™ tracheostomy tubes ...
Aire-Cuf® tracheostomy tubes are ideal for short-term to medium-term ventilator support....
Medicine Products: