Navigation Links
New drug for children with high-risk leukemia
Date:7/28/2009

inspired to screen for gene mutations that could result in increased proliferation of cells. In collaboration with the iBFM Study Group, a European childhood leukemia consortium, 90 cases of Down syndrome leukemia from all over Europe were studied. A JAK2 mutation was found in 20% of these cases.

The discovery represents a unique biological phenomenon. "This is perhaps the first example of two very similar ― but different ― mutations that apparently do the same thing in a cellular protein. But they're associated with two completely different disorders, one that causes polycythemia in adults and the other that causes leukemia in children," says Dr. Izraeli.

"Those children at the highest risk for leukemia may be treated with inhibitors of JAK2," he says. "And because of the existence of polycythemia in adults, there are already drugs to fight polycythemia entering into trials as we speak. We will know in just a few years what these drugs are capable of."

An alternative to chemotherapy

Dr. Izraeli says the discovery offers "potential hope" to children who suffer from leukemia. "JAK2 inhibitors are not based on chemotherapy. The first experiences with these treatments show very few side effects. All that researchers need to do is to expand these clinical trials to children and adults with high-risk leukemia ― and that can happen relatively quickly," says Dr. Izraeli.

Dr. Izraeli explains that typical chemotherapies for leukemia also have a high "toxicity cost." Children with leukemia are treated with 10 to 12 different chemotherapies over a period of two to three years. Some of them have long-term and irreversible damage, such as neurological, heart, bone problems and sterility. Researchers looking for viable alternatives may turn to Dr. Izraeli's research as a promising avenue for success.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Children of depressed moms do better when dad is involved, SLU researcher finds
2. High pollution linked to poor lung function growth in children in Mexico City
3. NYC-area 1st: Morgan Stanley Childrens Hospital performs transcatheter pulmonary valve replacement
4. Obese Children Miss More School Days
5. Ultra-Runner to Run 63 Marathons in 63 Days for Children with Incurable Disease
6. Psoriasis Cure Now offers Back to School Resources for Parents of Children with Psoriasis
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Practice-based intervention has sustained benefits for children and families
10. 1.5 million children could be saved
11. Annual flu shot cuts need for doctors visits, hospitalization among children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/21/2014)... Theme and plugin developers ... plugin for Final Cut Pro X entitled ProMotion. , ... more with absolute ease.” Said Christiana Austin, CEO of ... needed to easily animate their media inside FCPX.” , ... users to animate pictures, videos, logos, and more with ...
(Date:12/20/2014)... BambooIndustry.com is a professional company ... business has recently shown its new engineered bamboo flooring ... bamboo flooring models. , BambooIndustry.com’s customers come from many ... more. According to the CEO of the company, the ... in the past few years, and the demand for ...
(Date:12/20/2014)... Dress company LunaDress has recently announced its ... Christmas Sale, offering big discounts on all of its special ... idea to own a perfect wedding gown. If you have ... then come to LunaDress. Many different wedding dress styles and ... website now and enjoy the current special offer, up to ...
(Date:12/20/2014)... (PRWEB) December 20, 2014 The Doctor’s Office ... for the better part of a decade. They’ve treated ... a better, faster healthcare alternative to the Paramus ... announce three new additions to their staff of top-notch board ... Jill Zeiger MD. These new doctors will work ...
(Date:12/20/2014)... December 20, 2014 Recently, AngelWeddingDress.com has ... Discount ”) for the coming Christmas. In the promotion, ... 80% off. , “We have something special for the ... the holiday season. Moreover, our new collections of 2015 ... are offered now at greatly discounted prices. Visit our ...
Breaking Medicine News(10 mins):Health News:Announcing a new plugin for Final Cut Pro X ProMotion from Pixel Film Studios. 2Health News:BammbooIndustry.com: Big Discounts On All Kinds Of Bamboo Flooring Collections 2Health News:2015 Collection of Wedding Dresses from LunaDress Online on Sale Now 2Health News:The Doctor's Office Urgent Care Adds 3 New Physicians to Their Growing Medical Team 2Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2
... recent report in Nature Medicine had said that the ... Encephalitis in India is due to lack of preparedness ... early vaccination programs//. The encephalitis infection is spread by ... in water logged paddy fields in the monsoon seasons. ...
... in the July issue of the journal Environmental Health ... levels and age of onset of natural menopause//. ... to reflect the rate of atrophy of the ovarian ... health implications because women with early menopause are at ...
... for its miraculous properties, Herceptin, the breast cancer wonder ... British medical journal questioned its effectiveness//. ,"The ... is profoundly misleading to suggest, even rhetorically, that the ... breast cancer," the editors of The Lancet wrote in ...
... role in female mortality, second only to infanticide in Asian ... student of economics at Harvard University//, found that infanticide may ... to female ratios in many Asian countries, reports science portal ... particularly China, where some 10 to 15 percent of the ...
... a multinational company to bring a cost effective vaccine ... Minister Anbumani Ramadoss //on the occasion of National Cancer ... cancer has been instrumental behind the initiative. ... mobilizing things to implement the plan in association with ...
... that reflecting on personal values can keep neuroendocrine and ... is implicated in the development //and progression of a ... and research on the self suggest that self-affirming activities ... study, published in the November issue of the journal ...
Cached Medicine News:Health News:Herceptin Not A ‘Wonder’ Drug, Says The Lanc 2Health News:Cervical Cancer Vaccine To Be Developed In India 2
(Date:12/17/2014)... and SAN DIEGO , Dec. 17, 2014 ... ; AEX: PHIA) and Volcano Corporation (NASDAQ: VOLC ... for cardiovascular applications, today announced that they have entered into ... commence a tender offer to acquire all of the issued ... or a total equity purchase price of USD 1 billion ...
(Date:12/17/2014)... Dec. 17, 2014  Strategic Health Services, Inc. (SHS), ... today announced a strategic agreement with QualCare, Inc., a leading ... Jersey regional marketplace.  This agreement will further ... and wellness solutions QualCare brings to its clients in ... region. QualCare plans cover more than ...
(Date:12/17/2014)... , Dec. 17, 2014  Beamz Interactive, Inc. ... music products, today announced that it has signed ... manufacturer and supplier of innovative prosthetic, orthotic and ... part of the agreement, RSL Steeper will promote ... specifically configured for use within UK residential care ...
Breaking Medicine Technology:Philips to acquire Volcano to expand global leadership position in image-guided therapy market 2Philips to acquire Volcano to expand global leadership position in image-guided therapy market 3Philips to acquire Volcano to expand global leadership position in image-guided therapy market 4Philips to acquire Volcano to expand global leadership position in image-guided therapy market 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 6Philips to acquire Volcano to expand global leadership position in image-guided therapy market 7Philips to acquire Volcano to expand global leadership position in image-guided therapy market 8Strategic Health Services to collaborate with QualCare on Population Health and Wellness Technology for QualCare Members 2Strategic Health Services to collaborate with QualCare on Population Health and Wellness Technology for QualCare Members 3Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 3
... Calif., Sept. 1, 2011 Please replace the release ...  First graph, second and third sentences added and should ... presentation, which will be filed in a Form 8K ... financial markets on Friday, September 9, 2011.  This presentation ...
... Inc. (OTCQB: FROI) (the "Company") is pleased to announce the ... President.  Mr. Lopez replaces Kyle Schlosser, who had served as ... is currently the Chief Operating Officer of the Company and ... (the 98% owned Fero Industries operating subsidiary in Mexico) and ...
Cached Medicine Technology:UPDATING and ADDING: Questcor Pharmaceuticals to Present at Upcoming Investor Conferences in September 2UPDATING and ADDING: Questcor Pharmaceuticals to Present at Upcoming Investor Conferences in September 3Fero Industries Appoints Lopez as President 2Fero Industries Appoints Lopez as President 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: