Navigation Links
New drug combo targets multiple cancers
Date:11/16/2011

n barrier.

After first determining that in vitro cancer cells incubated with 2-DG and exposed to low concentrations of ABT-263/737 died, the researchers conducted animal studies. They found that when 2-DG was injected into animals, it predominantly accumulated in cancer cells that were subsequently killed by an injection of ABT-263/737. The two-step approach successfully induced apoptosis in leukemia, hepatocarcinoma, lung, breast and cervical cancers. Yamaguchi said it caused cell death at many stages of cancer development, including a difficult-to-treat, chemo-resistant, highly metastasized form of prostate cancer.

"Since the combination of 2-DG and ABT-263/737 induces rapid apoptosis through the intrinsic pathway, meaning through mitochondria, it leaves little room for interference by a cancer cell's highly active mutagenic programs," Perkins said.

The combined treatment, however, does not work on all cancers. "There are certain cancers that are resistant or in which this would cause lymphopenia and thrombopenia," said Yamaguchi. Lymphopenia and thrombopenia are a loss of white blood cells or platelets, respectively. The scientists are developing "workarounds" to counteract these adverse effects, possibly by using stored hematopoietic stem cells for transplant after treatment.

"We are now trying to initiate a clinical trial for the combination," said Yamaguchi. "Since both 2-DG and ABT-263 (Navitoclax) are already in Phase II clinical trials (for other treatments), we know something about the safety of these agents. Once we take precautionary measures, the 2-DG-ABT combination therapy may prove an effective alternative to some existing cancer therapies. We may have found a simple, partial solution to a very complex disease."


'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Breast tenderness in women getting combo hormone therapy associated with increase in breast density
2. FDA Approves First Combo Drug for Diabetes, Cholesterol
3. Drug Combo Might Fight Aggressive Breast Cancer More Safely
4. For Some Prostate Cancer Patients, Combo Treatment Improves Survival
5. New Combo Therapy May Prevent TB, Save Lives in People With HIV
6. Vitamin D, Calcium Combo May Halve Melanoma Risk in Some Women
7. Energy Drink-Vodka Combo Nearly Kills Teen
8. Daily Four-Drug Combo Pill Halves Heart Disease Risk: Study
9. Combo of Paxil, Pravachol May Raise Blood Sugar
10. Chemo Combo May Help Stave Off Pancreatic Cancer Death
11. Alcohol-Energy Drink Combo Riskier Than Booze Alone, Study Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Auckland, NZ (PRWEB) August 29, 2014 ... of Greg Allen to Chief Executive Officer effective from ... Chief Technology Officer for Winscribe. , “During this time ... Winscribe than Greg Allen,” said Matthew Weavers, Winscribe’s Founder ... leader with a wealth of commercial, IT and management ...
(Date:8/28/2014)... 2014 Career Step, an online provider ... new video designed to help students and career seekers ... billing field. The video details what medical coders and ... professionals, and the education requirements for entering this field. ... often overlooked when people are considering a career in ...
(Date:8/28/2014)... FL (PRWEB) August 29, 2014 ... that brings pharmaceutical industry precision to the development ... zoning approval for its primary location in Sarasota ... and decisively with a total commitment to attracting ... forward to creating," says David Wright, President and ...
(Date:8/28/2014)... When David Gergen, President of ... Mark Brnovich, was asked to publicly support Mr. Brnovich ... Attorney General seat in the State of Arizona, Mr. ... of Cardinal Hall of Fame wide receiver Roy Green ... Mark Walczak. Green, Kennard and Walczak are members of ...
(Date:8/28/2014)... Farmington, New York (PRWEB) August 29, 2014 ... Autumn as they will be traveling around the country ... with a final show in November. The New Energy ... exhibit sharing their timber frame design and build expertise, ... addition, Drake Ambrosino , New Energy Works’ Mid-West ...
Breaking Medicine News(10 mins):Health News:Winscribe Names Greg Allen as CEO 2Health News:Career Step Releases New Video Designed to Help Students Explore the Medical Coding and Billing Field 2Health News:Sarasota County Approves Zoning for Leading Medical Cannabis Firm AltMed 2Health News:Pro Player Health Alliance Back in the Political Arena 2Health News:Pro Player Health Alliance Back in the Political Arena 3Health News:New Energy Works Timberframers Prepares to Exhibit Timber Framing at Autumn Trade Shows 2Health News:New Energy Works Timberframers Prepares to Exhibit Timber Framing at Autumn Trade Shows 3
... ... recent launch of accounts on the popular social networking sites, Facebook, Twitter, and LinkedIn. ... Las Vegas, ... consultations, diagnoses, prescriptions, and doctors, excuses for work and school, expands its outreach to ...
... SEATTLE, Aug. 27 IDRI (Infectious Disease Research ... in Sudan to test its leishmaniasis vaccine candidate for ... complication of visceral leishmaniasis (VL) which is observed in ... predominantly affecting children. This trial reflects IDRI,s commitment to ...
... PRINCETON, N.J., Aug. 27 More than 160 ... are coming together at educational summits sponsored this fall by ... Continuing Education (CBCE). For the fifth year, the Inhibitor Education ... professionals and fellow patients to address pertinent topics such as ...
... rates similar to those with deceased donor transplant organs, ... People with kidney disease may do just as well ... from a deceased donor, new research has found. , ... 1,239 patients who had either received a kidney transplant ...
... Japan, Aug. 27 Hisamitsu Pharmaceutical Co., Inc. (TSE: ... completion of the tender offer for all outstanding shares of Noven ... price per share of $16.50. The subsequent offering period expired ... 2009 and was not extended. , , ...
... , MAPLE GROVE, Minn., Aug. 27 NeuroVasx, Inc., ... hemorrhagic and ischemic stroke, announced today that it has received approval ... Canada,s Therapeutic Products Directorate. In addition to Canadian regulatory approval, ... , Eric B. Timko, President and Chief Executive ...
Cached Medicine News:Health News:KoolDocs.com Increases Online Presence through Social Networking Premium Online Medical Consultation Service Now on Facebook, Twitter, and LinkedIn 2Health News:IDRI Initiates Therapeutic Vaccine Clinical Trial in Sudan Against Leishmaniasis 2Health News:IDRI Initiates Therapeutic Vaccine Clinical Trial in Sudan Against Leishmaniasis 3Health News:Patient Education Summits to Address Special Challenges of Hemophilia Patients and Their Families 2Health News:Patient Education Summits to Address Special Challenges of Hemophilia Patients and Their Families 3Health News:Patient Education Summits to Address Special Challenges of Hemophilia Patients and Their Families 4Health News:Home Dialysis a Good Option for Kidney Disease Patients 2Health News:Hisamitsu Pharmaceutical Announces Expiration of Subsequent Offering Period and Completion of Tender Offer for Outstanding Shares of Noven Pharmaceuticals 2Health News:NeuroVasx Receives Canadian Approval for cPAX Aneurysm Treatment System 2Health News:NeuroVasx Receives Canadian Approval for cPAX Aneurysm Treatment System 3
(Date:8/28/2014)... Calif. , Aug. 28, 2014  In anticipation of ... infographic is being made available for the first time. ... Diego offers a snapshot of ... Highlighting everything from the latest employment statistics to ... made San Diego such a vital ...
(Date:8/28/2014)... Aug. 28, 2014 Levi & Korsinsky announces ... the United States District Court for the District of ... who purchased Galectin Therapeutics Inc. ("Galectin" or the "Company") ... 28, 2014. For more information, click here: ... during the Class Period the Company violated federal securities ...
(Date:8/28/2014)... CHARLOTTE, N.C. , Aug. 28, 2014 /PRNewswire/ ... innovation marketplace, today announced a worldwide search for ... of the senior population.  Promising ideas uncovered through ... presented to leading medical device manufacturers and healthcare ... to improve the lives of individuals age 65 ...
Breaking Medicine Technology:New Infographic Published - Overview of Medtech & Life Sciences Industry in San Diego 2SHAREHOLDER ALERT: Levi & Korsinsky, LLP Reminds Investors of Class Action Against Galectin Therapeutics Inc. and Its Board of Directors and a Lead Plaintiff Deadline of September 29, 2014 -- GALT 2Edison Nation Medical Launches Open Innovation Search to Uncover Innovative Senior Care Products 2Edison Nation Medical Launches Open Innovation Search to Uncover Innovative Senior Care Products 3
... BEVERLY, Mass.--(BUSINESS WIRE)--Apr 10, 2007 - Inotek,Pharmaceuticals Corporation ... preclinical animal data showing that the,administration of a ... on the survival of certain brain,cells following a ... the,repair of damaged DNA via the activation and ...
... study appearing in the March,22 New England Journal ... Healths National Institute of Arthritis and,Musculoskeletal and Skin ... gene and the inflammatory skin,condition vitiligo, as well ... is a chronic condition in which melanocytes (the ...
Cached Medicine Technology:Inotek Pharmaceuticals Announces Publication of Animal Data from,Study of PARP Inhibition as Potential Preventative of Brain Injury,Following Stroke 2Inotek Pharmaceuticals Announces Publication of Animal Data from,Study of PARP Inhibition as Potential Preventative of Brain Injury,Following Stroke 3Scientists Implicate Gene in Vitiligo and Other Autoimmune Diseases 2Scientists Implicate Gene in Vitiligo and Other Autoimmune Diseases 3
Colorimetric Assay of Antithrombin III Activity by STA© Analyzers. Bovine thrombin ~12NIH units/mL, freeze-dried....
Immuno-turbidimetric assay for Free Protein Sby STA© Analyzers. Suspension of microparticles coated with monoclonal antibodies to Free Protein S....
Colorimetric Assay of Unfractionated and Low Molecular Weight Heparins by STA© Analyzers. Lyophilized, patent-pending chromogenic substate, CBS 52.44 of ~4.2 moles/vial and bovine factor Xa ~1.1...
Substrate Plasma for Factor VII Assay by STA© Analyzers. Freeze-dried human plasma from which factor VII has been removed by selective immuno-adsorption....
Medicine Products: