Navigation Links
New drug combination could prevent head and neck cancer in high-risk patients
Date:2/19/2013

PHILADELPHIA A new drug combination shows promise in reducing the risk for patients with advanced oral precancerous lesions to develop squamous cell carcinoma of the head and neck. The results of the study, which included preclinical and clinical analyses, were published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

"Squamous cell carcinoma of the head and neck (SCCHN) is the most common type of head and neck cancer," said Dong Moon Shin, M.D., professor of hematology, medical oncology and otolaryngology at Emory University School of Medicine, and director of the Cancer Chemoprevention Program at Winship Cancer Institute at Emory University in Atlanta, Ga. "The survival rate for patients with SCCHN is very poor. An effective prevention approach is desperately needed, especially since we can identify patients who are at extremely high risk: those with advanced oral precancerous lesions."

Based on prior research suggesting a role for epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) in promoting SCCHN, Shin and colleagues believed combining an EGFR inhibitor and a COX-2 inhibitor could provide an effective chemopreventive approach.

They found that the combination of the EGFR inhibitor erlotinib and the COX-2 inhibitor celecoxib was more effective for inhibiting the growth of human SCCHN cell lines compared with either drug alone. In addition, treating mice with the drug combination prior to transplanting them with human SCCHN cells more effectively suppressed cancer cell growth than did pretreating the mice with either drug alone.

Based on these preclinical analyses, Shin and colleagues initiated a phase I chemoprevention trial. Eleven patients with advanced oral precancerous lesions were assigned to treatment with erlotinib and celecoxib. Tissue samples from the patients were obtained and evaluated pathologically at three, six and 12 months after therapy i
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mayo Clinic: 2-drug combination may slow deadly thyroid cancer
2. People with HIV hospitalized less often since combination antiretroviral drug therapy introduced
3. Combination of imaging exams improves Alzheimers diagnosis
4. Drug combination acts against aggressive chronic lymphocytic leukemia
5. Scientists test 5,000 combinations of 100 existing cancer drugs to find more effective treatments
6. Combination treatment may improve survival of breast cancer patients with brain metastases
7. Drug combination against NRAS-mutant melanoma discovered
8. Combination peptide therapies might offer more effective, less toxic cancer treatment
9. DNDi and Cipla to develop 4-in-1 pediatric antiretroviral drug combination
10. BUSM in vitro study identifies potential combination therapy for breast cancer
11. Moffitt Cancer Center researchers test drug combinations to prevent graft vs. host disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... Dallas, Texas (PRWEB) August 23, 2014 ... deterioration of the function of the myocardium (the ... heart failure; common symptoms are dyspnea (breathlessness) and ... cardiomyopathy are often at risk of dangerous forms ... The most common form of cardiomyopathy is dilated ...
(Date:8/23/2014)... Peripheral intervention surgeries are part of the ... addressing the root cause of peripheral artery disease. Peripheral ... other part of the arteries where the blood clot ... the use of a catheter, (which is a thin ... are inserted through a thin cut in an artery, ...
(Date:8/23/2014)... York, New York (PRWEB) August 23, 2014 ... http://www.consumerinjurylawyers.com/wright-conserve-hip-replacement.html ) filed on behalf of individuals ... the Conserve hip replacement line continue to move ... of Georgia, Bernstein Liebhard LLP reports. According to ... established a bellwether trial program that would allow ...
(Date:8/23/2014)... 2014 Professional kitchen employees, prospective chefs ... in preparing for Food Safety Certification exams thanks to ... Dynamic Path. , Dynamic Path announced the release of ... than 200 review questions for culinary industry students and ... cover requirements of the ServSafe® Food Safety Certification, National ...
(Date:8/23/2014)... August 23, 2014 Teen drug and ... It’s no different in Wilmington, NC. Substance abuse can ... falling victim to drug and alcohol dependency in higher ... looking to overcome substance abuse, but don’t know where ... treatment facility can be a challenge because most treatment ...
Breaking Medicine News(10 mins):Health News:Cardiomyopathy (Heart Muscle Disease) Therapeutics Clinical Trials Market 2014 Analysis in a New Report Available at MarketOptimizer.org 2Health News:Cardiomyopathy (Heart Muscle Disease) Therapeutics Clinical Trials Market 2014 Analysis in a New Report Available at MarketOptimizer.org 3Health News:Cardiomyopathy (Heart Muscle Disease) Therapeutics Clinical Trials Market 2014 Analysis in a New Report Available at MarketOptimizer.org 4Health News:Global Peripheral Intervention Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Health News:Global Peripheral Intervention Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Health News:Global Peripheral Intervention Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 4Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 2Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 3Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 4Health News:Food Handler Safety Certification Made Easy with Dynamic Path 2Health News:Troubled Teens Wilmington Helpline Guides Adolescents to the Path of Recovery 2
... thermal performance of protective clothing worn by firefighters. A ... the burns received by firefighters when they are not ... burns. Researchers at North Carolina State University have developed ... suits to be evaluated for their ability to prevent ...
... and nutritional benefits; Packaging now more environmentally responsibleNEW YORK, ... to the enhanced water category, PepsiCo (PEP) is re-launching ... water beverage designed to help hydrate and nourish the ... Propel is available in a variety of ...
... In recognition of April as National Autism Awareness Month, LoJack Corporation ... at: http://www.lojack.com/knowledge/Documents/AutismAwarenessMonth.mp3 ) that provided valuable ... The rising incidence of autism in ... challenges of caring for an autistic child , ...
... no problems at 6 months of use , , TUESDAY, ... Cialis (tadalafil) and Viagra (sildenafil) didn,t appear to damage ... six months, according to a drug company study. , ... treat erectile dysfunction by interfering with the action of ...
... marketing exclusivityPITTSBURGH, April 14 Mylan Inc. (Nasdaq: ... its subsidiary Mylan Pharmaceuticals Inc. have been sued by ... an Abbreviated New Drug Application (ANDA) with the U.S. ... mg and 500 mg, the generic version of Xeloda(R) ...
... WILMINGTON, Del., April 14 Patent litigation firm Teuton, ... Therative, Inc. on behalf of inventor Joseph Neev, PhD. ... District Court, District of Delaware, Dr. Neev claims sole ... issued patent that Therative claims protects its ThermaClear Acne ...
Cached Medicine News:Health News:NC State develops new test method to measure stored heat in firefighter suits 2Health News:Propel Unveils New Enhanced Experience 2Health News:Propel Unveils New Enhanced Experience 3Health News:April is National Autism Awareness Month: LoJack Hosts Educational Podcast Featuring Panel of Experts Addressing Autism Issues 2Health News:Impotence Drugs Don't Harm Vision: Study 2Health News:Mylan Confirms First-to-File Patent Challenge Relating to Xeloda(R) Cancer Treatment 2Health News:Inventor Sues Therative, Inc. Over Inventorship of Patent on ThermaClear Device; Separate Invention Theft Case Continues 2
(Date:8/22/2014)... 22, 2014 Research ... addition of the  "Global Operating Room Equipment ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,An operating ... environment in a healthcare facility used to ... technically advanced equipment, which ensures patient care ...
(Date:8/22/2014)... /CNW/ - On Aug. 20, at its annual meeting ... Association (CMA) voted on and approved a delegate resolution ... cannabis. Bedrocan Cannabis Corp., a leading Canadian licensed producer ... The CMA is quite right to point ... any plant material, including medicinal cannabis. While some patients, ...
(Date:8/22/2014)... , Aug. 22, 2014 Research and ... "Global and Chinese Intravenous Catheter Industry Report 2014" ... and Chinese Intravenous Catheter Industry Report 2014 is a ... the global intravenous catheter industry with a focus on ... overview of the industry including definitions, classifications, applications and ...
Breaking Medicine Technology:Global Operating Room Equipment Market 2014-2018: Key Vendors are Getinge, STERIS, Stykron and TRUMPF Medical Systems 2Bedrocan Canada Statement Regarding Canadian Medical Association Motion on Smoking Marijuana 2Global and Chinese Intravenous Catheter Industry Report 2014 2
... 2, 2012 CVS Caremark Corporation (NYSE: CVS ) ... months ended March 31, 2012. (Logo: http://photos.prnewswire.com/prnh/20090226/NE75914LOGO ... , Net revenues increased 19.9% to a record $30.8 ... , Retail Pharmacy segment same stores sales increased ...
... Ill., May 2, 2012  Celebrity chef Spike Mendelsohn knows all ... – especially for a person with acid reflux disease (ARD). ... Spike has also had to learn how to turn down ... awareness and understanding about the importance of managing heartburn symptoms ...
Cached Medicine Technology:CVS Caremark Reports Record First Quarter Results 2CVS Caremark Reports Record First Quarter Results 3CVS Caremark Reports Record First Quarter Results 4CVS Caremark Reports Record First Quarter Results 5CVS Caremark Reports Record First Quarter Results 6CVS Caremark Reports Record First Quarter Results 7CVS Caremark Reports Record First Quarter Results 8CVS Caremark Reports Record First Quarter Results 9CVS Caremark Reports Record First Quarter Results 10CVS Caremark Reports Record First Quarter Results 11CVS Caremark Reports Record First Quarter Results 12CVS Caremark Reports Record First Quarter Results 13CVS Caremark Reports Record First Quarter Results 14CVS Caremark Reports Record First Quarter Results 15CVS Caremark Reports Record First Quarter Results 16Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 2Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 3Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 4Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 5
Used for drainage and retrograde pyelogram. The spiral tip aids in negotiation of a tortuous or partially obstructed ureter. Supplied sterile in peel-open packages. Intended for one-time use....
Used for drainage and retrograde pyelogram. Supplied sterile in peel-open packages. Intended for one-time use....
Used for drainage and navigation of a tortuous ureter. The tapered tip eases placement as there are no edges to interfere with the ureteral orifice. Supplied sterile in peel-open packages. Intended f...
These flexible stone retrieval devices are reusable, 3 Fr in diameter, with a working length of either 60 cm or 115 cm...
Medicine Products: