Navigation Links
New drug combination brings 1-2 punch against acute leukemia
Date:5/16/2008

CINCINNATI, OHIO - Researchers at The University of Texas M. D. Anderson Cancer Center have discovered a drug combination that kills leukemia cells by shutting down their energy source and hastening cell starvation.

In a preclinical study, Lauren Akers, D.O., postdoctoral fellow from the Children's Cancer Hospital at M. D. Anderson, found that combining a novel glycolysis inhibitor, 3-BrOP, with mTOR inhibitor, rapamycin, induced more than 90 percent cell death in human tissue cultures of acute lymphocytic leukemia. She presented her study at the American Society of Pediatric Hematology/Oncology annual conference on May 16.

"We already knew that 3-BrOP was effective in preclinical research of glioblastoma, colon cancer and lymphoma, and most recently acute leukemias" says Akers, lead investigator on the study. "We also knew that mTOR inhibitors intensify cellular starvation. This study showed that the two together have a more powerful impact on treating acute lymphocytic leukemia, which is the most common childhood cancer."

Glycolysis is a process that turns glucose into energy for cells. Unlike healthy cells that get their energy for growth from both glycolysis and respiration, cancer cells are highly dependent on glycolysis. Using the M. D. Anderson-developed drug, 3-BrOP, researchers inhibited glycolysis, thus starving the leukemia cells from their energy source while leaving healthy cells free to get their energy from respiration.

Rapamycin is an mTOR inhibitor that keeps cancer cells from coping with stress, thus resulting in cell death. When researchers on the study combined the two drugs, they discovered a synergistic effect.

"We found that a lower dosage of 3-BrOP with rapamycin created the same results of more than 90 percent tumor cell death," says Akers. "Theoretically, we believe that patients will better tolerate the therapy by lowering the dosage of 3-BrOP and combining it with rapamycin."


'/>"/>
Contact: Sara Farris
sfarris@mdanderson.org
281-467-1337
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Promising drug combination may help those with ocular melanoma that has spread
2. Combination therapy reverses effects of portal hypertension in rats
3. Combination vaccines okay for infants, study shows
4. Antidepressants and painkillers - a dangerous combination
5. Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
6. U.S. Oncology Initiates Complete Phase Ib Trial of Brostallicin Combination Therapy in Advanced Solid Tumors
7. Drug combination might offer hope for patients deadly brain tumors
8. EpiCept to Present Preclinical Studies of EPC2407 in Combination With Anti-Angiogenic and Chemotherpeutic Agents at the AACR-NCI-EORTC International Conference
9. Combination targets: some drugs may work best when they work together
10. MAP Pharmaceuticals Initiates Phase 2a Clinical Trial of Combination Therapy in Adult Patients with Asthma
11. Quality Control: Nissan Quest to Feature micronAir(R) Combination Cabin Air Filters
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New drug combination brings 1-2 punch against acute leukemia
(Date:7/23/2014)... Steven Reinberg HealthDay ... -- Many obese and overweight American children and teens ... is fine, U.S. health officials reported Wednesday. "Being ... such as high blood pressure, high cholesterol and diabetes," ... the U.S. Centers for Disease Control and Prevention,s National ...
(Date:7/23/2014)... 2014 Home Care Assistance Calgary ... seniors, is proud to announce the next installment in ... a wide range of health and wellness-related fields. The ... award-winning author Nancy Kriseman, and will cover the most ... burnout by becoming more self-aware. In particular, Nancy will ...
(Date:7/23/2014)... new study supports a growing body of research ... steroid hormones in treating postmenopausal breast cancer, with ... than with standard anti-hormone therapies. The study will ... open-access journal Reproductive Biology and Endocrinology . ... cancer in women in the United States. Approximately ...
(Date:7/23/2014)... DC (PRWEB) July 23, 2014 ... for ATA 2015, ATA’s twentieth annual meeting and ... The meeting, expected to attract over 5,000 attendees ... will take place May 3-5, 2015, in Los ... most renowned healthcare technology professionals from researchers, clinicians, ...
(Date:7/23/2014)... X syndrome ( FXS ) is a genetic disorder ... on the autistic spectrum, as well as cognitive deficits. ... impairment and the most common cause of autism. , ... have published a study that sheds light ... online today (July 23) in the Journal of ...
Breaking Medicine News(10 mins):Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 2Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 3Health News:Home Care Assistance Calgary to Host Public Webinar on the Topic of Caregiver Mindfulness 2Health News:Home Care Assistance Calgary to Host Public Webinar on the Topic of Caregiver Mindfulness 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 4Health News:Hormones after breast cancer: Not fuel for the fire after all? 5Health News:ATA Seeks Speakers to Present at the World’s Largest Telemedicine, mHealth and Telehealth Conference 2Health News:Study links enzyme to autistic behaviors 2Health News:Study links enzyme to autistic behaviors 3
... provides the strongest evidence yet that a key portion of ... assessment// for toxins is wrong when it comes to measuring ... a scientist at the University of Massachusetts Amherst. The findings, ... 13 strains of yeast using 2,200 drugs, are published in ...
... suffering from chronic diseases are faced with uncertainty and ... Some may feel embarrassed to trouble others with their ... in Toronto, can expect to be linked to a ... themselves actively in their treatment. ,This online ...
... stressful conditions provide immunity// to face stressors which they ... ,Scientists from National Institute of Mental Health (NIMH) have ... against such hard knocks - the circuitry of resilience. ... hub, the prefrontal cortex, but also altered it so ...
... with calories. Most often, despite knowing that a particular dish ... because we are unaware of how many extra calories actually ... would take to burn those calories. , ,A ... diet-calorie reckoner, has enabled a true account of the amount ...
... of the lowest premium rise of about 4 per cent ... equates to about $1.50 a week extra on a typical ... The private cover will also be expanded to include a ... at home. ,Health Minister Tony Abbott is putting ...
... (SE) is present in eggs sometimes, and when preparations //made ... cause illness. The FDA (The U. S. Food and Drug ... follow food safety practices to avoid egg-related illness. ... and some types of stuffing, contain eggs that are raw ...
Cached Medicine News:Health News:New Study Challenges How Regulators Determine Risk 2Health News:An Online Portal To Aid Kidney Patients 2Health News:Prior Experience to Stress Acts as an Immunization 2
(Date:7/23/2014)... , July 23, 2014 Today,s U.S. ... to treat patients with relapsed chronic lymphocytic leukemia ... (SLL) is a significant advance for patients with ... goes by the trade name Zydelig®, is a ... is highly expressed in many B-cell malignancies and ...
(Date:7/23/2014)... 2014  Varian Medical Systems (NYSE: VAR ... diluted share in the third quarter of fiscal year ... per diluted share due to an approximately $8 million ... equity investment in Augmenix, a privately-held company developing minimally ... million for the third quarter of fiscal year 2014, ...
(Date:7/23/2014)... UBM Medica US today announced the launch ... and information resource for neurologists and other healthcare providers ... with neurological disorders . The prevalence ... greater access to dedicated information for healthcare providers who ... include: , 1 in 6 people are ...
Breaking Medicine Technology:The Leukemia & Lymphoma Society Applauds FDA's Approval of Idelalisib To Treat Three Types of Blood Cancers 2Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 2Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 3Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 4Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 5Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 6Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 7Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 8Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 9Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 10UBM Medica US Launches NeurologyTimes.com 2UBM Medica US Launches NeurologyTimes.com 3
... The Self-Cath family of ... patients a variety of ... Each catheter is ... grade PVC and has ...
... The Self-Cath family of ... patients a variety of ... Each catheter is ... grade PVC and has ...
IMMCO ANA Elisa meets the guidelines for the laboratory diagnosis and monitoring of systemic autoimmune rheumatic diseases intended for the use of clinical pathologists and laboratory physicians....
... is engineered to distribute contact pressure evenly over ... back, to maximize stability and patient comfort. ... readily conformable to patient anatomy, to provide a ... wool liner is standard on both units, as ...
Medicine Products: