Navigation Links
New drug candidates show promise for cure for Chagas disease
Date:12/26/2013

A team of researchers from Canada has developed a class of compounds which may help eradicate a neglected tropical disease that is currently hard to kill in its chronic form. The research was published ahead of print in Antimicrobial Agents and Chemotherapy.

Chagas disease or American trypanosomiasis, caused by Trypanosoma cruzi, affects about 18 million people living mostly in Latin America. The parasite is transmitted to humans by blood-sucking reduviid bugs, also known as kissing bugs due to their predilection for feeding on the faces of their victims. In the United States, Chagas disease is considered one of the neglected parasitic infections, a group of five parasitic diseases that have been targeted by CDC for public health action.

"While historically infection was largely confined to poor and rural populations in Central and South America, it has been emerging in the U.S., Canada, Europe, Japan, and Australia, due to immigration, and nonvectorial transmission is becoming a public health threat," says Deborah Nicoll-Griffith of the Merck Frosst Centre for Therapeutic Research in Kirkland, Quebec, a researcher on the study. One 2005 estimate put the number of people infected within the U.S. at 300,000 (1/1000).

There are two phases of Chagas disease: the acute phase and the chronic phase. Both phases can be symptom free or life threatening. Left untreated the disease can lead to cardiac and digestive disorders, as the parasite burrows into the heart, esophagus and colon tissue where it causes damage over time.

The current standard of care, the drug benznidazole, has significant activity against the parasite during the acute phase, but is less effective once the disease becomes chronic.

Efforts to find new drugs focus on disrupting an enzyme, cruzipain, which the parasite uses for digestion, to produce other cellular machinery, to evade the host's immune system, and to invade heart and gastrointe
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Innovative Screening Strategy Swiftly Uncovers New Drug Candidates, New Biology
2. Dissertation Pal Introduces Statistics Help for Doctoral Candidates
3. Women's Strike Force Announces First Fund Distribution to Virginia House of Delegates Candidates for November Race
4. Issue III registry defines best syncope candidates for cardiac pacing
5. Genetic variations may help identify best candidates for preventive breast cancer drugs
6. Drugs targeting blood vessels may be candidates for treating Alzheimers
7. NIH-funded researchers begin trial of Shigella vaccine candidates
8. Katon Direct, a Healthcare Micro-Marketing Solutions Company, Launches Their New Website, Innovating the way Healthcare Companies Find the Most Qualified Candidates
9. Presidential candidates should address childhood obesity and bullying, poll says
10. Novel drug candidates offer new route to controlling inflammation
11. With Over 12 Million Christmas Wishes Viewed at 123Greetings.com Last Year, Christmas 2013 Promises Even More Cheers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... SF Cable, distributor of the highest quality cables, ... internet with guaranteed customer satisfaction announces the availability of ... These lightning cords are MFI certified to meet Apple ... Cable Lightning to USB Cables feature the ... and syncing. Compatible with the iPhone 5S/5C/5 plus iPad ...
(Date:7/30/2014)... The family of a Vermont man ... Xarelto lawsuit ( http://www.xareltolawsuitcenter.com/ ) alleging his death ... reports. According to the complaint, which was filed in ... July 25th, the decedent had been taking Xarelto for ... bleed that ultimately led to his death on August ...
(Date:7/30/2014)... 2014 Visitors to our region recognize ... to ensure its protection. Bob Kiesendahl, one of the ... the Delaware Highlands Conservancy for donations collected through participation ... donations add up fast, as visitors welcome the opportunity ... River Region. , The Kiesendahl family has owned Woodloch ...
(Date:7/30/2014)... obese people have a genetic mutation that seems to ... they see food, researchers report. Gaining a better ... and gratification at the sight of high-calorie foods like ... the scientists suggested. More than one-third of U.S. ... a combination of overeating, a lack of physical activity ...
(Date:7/30/2014)... DRE Medical — a leading medical ... of its Medical Trade Shows & Conventions Calendar ... and equipment vendors. , The calendar is a continually-updating ... United States and around the world. Hundreds of entries ... is always growing. , Information listed on each trade ...
Breaking Medicine News(10 mins):Health News:SF Cable Delivers Certified Lightning Cable in Multiple Sizes and Colors 2Health News:Xarelto Lawsuit Alleges Man’s Death from Uncontrollable Brain Bleeding Was Caused by Xarelto, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuit Alleges Man’s Death from Uncontrollable Brain Bleeding Was Caused by Xarelto, Bernstein Liebhard LLP Reports 3Health News:Pocono Mountain Resort Guests Contribute Over $8500 to Protect Land in 6 Short Months 2Health News:Gene Mutation May Make Food More Tempting 2Health News:DRE Launches Online Interactive Medical Trade Show Calendar 2
... School of Engineering and Applied Science have taken a ... successfully using the bacterium Escherichia coli to ... polyketides, which include important antibiotic and anticancer drugs. ... potent chemical compounds produced by living organisms; many are ...
... 2008 The Women,s Heart Health Initiative at the ... a new fellowship dedicated to gender-specific research that will ... in women. The announcement will take place during a ... "Women face unique challenges to successful diagnosis and treatment ...
... offered the perfect job. The not-so-good news it,s ... people with diseases like HIV, or those who are simply ... a medical exam to qualify for a job can be ... brings excellent news. , Medical exams are often not an ...
... Women with deficiency at time of delivery had almost ... 22 (HealthDay News) -- Vitamin D deficiency greatly increases ... U.S. researchers report. , During the two-year study, Boston ... examined the relationship between vitamin D levels in pregnant ...
... oncology researcher Dr. Daniel Von Hoff, a member ... an in-depth look at the "lost opportunity" in ... biotechnology companies use the phase I trial to ... Hoff advocates that it can also provide valuable ...
... from overweight and obesity. This is the result of a ... Elisabeth Weber and her coauthors present the results in the ... Arztbl Int 2008; 105 [51-52]: 883-9). The doctors recorded ... children, but also their mother tongue. Their parents had to ...
Cached Medicine News:Health News:E. coli engineered to produce important class of antibiotic, anti-cancer drugs 2Health News:A simple questionnaire to replace a doctor's exam 2Health News:Renowned Cancer Researcher Dan Von Hoff, M.D. Advocates for 'The Lost Opportunity in Phase I Oncology Trials' 2Health News:Renowned Cancer Researcher Dan Von Hoff, M.D. Advocates for 'The Lost Opportunity in Phase I Oncology Trials' 3Health News:Renowned Cancer Researcher Dan Von Hoff, M.D. Advocates for 'The Lost Opportunity in Phase I Oncology Trials' 4
(Date:7/30/2014)... /PRNewswire-iReach/ -- This is a professional and in-depth ... (CAS 9041-08-1) & calcium (CAS 37270-89-6) industry. The ... sodium (CAS 9041-08-1) & calcium (CAS 37270-89-6) including ... then explores global and China,s top manufacturers of ... listing their product specification, capacity, production value, cost, ...
(Date:7/30/2014)... , July 30, 2014   Bluegrass Vascular ... on innovating lifesaving devices and methods for vascular ... in Series A financing, which was led by ... the deal will allow Bluegrass Vascular to obtain ... System, enhance manufacturing capabilities, and proceed with US ...
(Date:7/30/2014)... , July 30, 2014 ... CUDA programming expertise to big data, aerospace and ... eInfochips, a leading engineering R&D services company, ... develop NVIDIA GPU-powered solutions for aerospace and ... computing (HPC), industrial , and ...
Breaking Medicine Technology:Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 2Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 3Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 4Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 5Bluegrass Vascular Technologies Raises $4.5M Series A Financing Led By Targeted Technology Funds 2eInfochips to Develop NVIDIA GPU-powered Solutions for Aerospace and Defense, Medical Imaging, HPC and Visual Computing 2
... Dec. 5, 2011   New product launches are continually ... critical for organizations to balance the dueling goals of containing ... executives face is determining how much to invest, and how ... budget for primary care launch is spent before ...
... 5, 2011 Technology is revolutionizing healthcare — making ... lowering the cost of care. AT&T ,s* new ... — is designed to do just that. The 2011 ... awarded to AT&T for its approach to mHealth, recognizing ...
Cached Medicine Technology:Launch Spend Insights: Companies Now Invest More in Launch Year Than in Previous 3 Ramp-Up Years Combined 2Frost and Sullivan Recognizes AT&T's Innovative mHealth Strategy 2Frost and Sullivan Recognizes AT&T's Innovative mHealth Strategy 3Frost and Sullivan Recognizes AT&T's Innovative mHealth Strategy 4
... a plastic device that fits over a standard ... a minimum amount of reagent. , , ... between the coverplate and slide. The liquid ... is dispensed into the well. Its pressure ...
ISI Micro Brushes are available in a variety of French diameters. Made with stainless steel handles and nylon bristles, the ISI Micro Brushes will last through countless cleanings....
... ISI offers instrument cleaning brushes ... diameters and composition. The long, ... cannulas and tubing. The smallest ... micros. The brass and stainless ...
... Nest is the wall organizer with a complete ... of sizes and diameters. Made of tough, durable ... Brush Nest is the ultimate organizer. , The ... in a variety of lengths, diameters and composition.,The ...
Medicine Products: