Navigation Links
New drug candidates show promise for cure for Chagas disease
Date:12/26/2013

A team of researchers from Canada has developed a class of compounds which may help eradicate a neglected tropical disease that is currently hard to kill in its chronic form. The research was published ahead of print in Antimicrobial Agents and Chemotherapy.

Chagas disease or American trypanosomiasis, caused by Trypanosoma cruzi, affects about 18 million people living mostly in Latin America. The parasite is transmitted to humans by blood-sucking reduviid bugs, also known as kissing bugs due to their predilection for feeding on the faces of their victims. In the United States, Chagas disease is considered one of the neglected parasitic infections, a group of five parasitic diseases that have been targeted by CDC for public health action.

"While historically infection was largely confined to poor and rural populations in Central and South America, it has been emerging in the U.S., Canada, Europe, Japan, and Australia, due to immigration, and nonvectorial transmission is becoming a public health threat," says Deborah Nicoll-Griffith of the Merck Frosst Centre for Therapeutic Research in Kirkland, Quebec, a researcher on the study. One 2005 estimate put the number of people infected within the U.S. at 300,000 (1/1000).

There are two phases of Chagas disease: the acute phase and the chronic phase. Both phases can be symptom free or life threatening. Left untreated the disease can lead to cardiac and digestive disorders, as the parasite burrows into the heart, esophagus and colon tissue where it causes damage over time.

The current standard of care, the drug benznidazole, has significant activity against the parasite during the acute phase, but is less effective once the disease becomes chronic.

Efforts to find new drugs focus on disrupting an enzyme, cruzipain, which the parasite uses for digestion, to produce other cellular machinery, to evade the host's immune system, and to invade heart and gastrointe
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Innovative Screening Strategy Swiftly Uncovers New Drug Candidates, New Biology
2. Dissertation Pal Introduces Statistics Help for Doctoral Candidates
3. Women's Strike Force Announces First Fund Distribution to Virginia House of Delegates Candidates for November Race
4. Issue III registry defines best syncope candidates for cardiac pacing
5. Genetic variations may help identify best candidates for preventive breast cancer drugs
6. Drugs targeting blood vessels may be candidates for treating Alzheimers
7. NIH-funded researchers begin trial of Shigella vaccine candidates
8. Katon Direct, a Healthcare Micro-Marketing Solutions Company, Launches Their New Website, Innovating the way Healthcare Companies Find the Most Qualified Candidates
9. Presidential candidates should address childhood obesity and bullying, poll says
10. Novel drug candidates offer new route to controlling inflammation
11. With Over 12 Million Christmas Wishes Viewed at 123Greetings.com Last Year, Christmas 2013 Promises Even More Cheers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... 31, 2014 The Memory Healer review published ... Alexander Lynch, whose father suffered from Alzheimer's disease. , ... caused by his father's disease. His father pointed a gun ... crucial moment when the author of this method understood that ... , The Memory Healer program is based on years of ...
(Date:10/31/2014)... 31, 2014 Monica Williams-Murphy MD ... all too well the chaos that can occur for ... “The vast majority of Americans who come into the ... are completely unprepared for the moment and so are ... can serve as a catalyst for a family to ...
(Date:10/31/2014)... Summit, Missouri (PRWEB) October 31, 2014 ... the country about families narrowly escaping carbon monoxide poisoning ... season) looms just weeks away, one family-owned, Missouri-based heating ... straightforward approach to making sure families start the home ... are safe and secure. , Beginning Nov. 1, ...
(Date:10/31/2014)... UT (PRWEB) October 31, 2014 ... new Activz Silver line offering natural silver ... wipes. For over a century, silver has been used ... in Activz Silver products is the most advanced version ... has a unique chemical structure that supports the existing ...
(Date:10/31/2014)... Surgery for low back pain caused by spinal stenosis ... live, a new report says. "Nearly 80 percent ... point in their lives, and about 30 million people ... problem," co-author Brook Martin, of the Dartmouth Institute of ... news release. In spinal stenosis, thickening of tissue ...
Breaking Medicine News(10 mins):Health News:"Memory Healer" Review Reveals a New Natural Remedy Guide for Managing Memory Loss 2Health News:This Thanksgiving or Christmas Family Gathering, Use The New App ListStuffFast to Start "The Conversation" With a Parent That Has No Plan For End-of-Life 2Health News:This Thanksgiving or Christmas Family Gathering, Use The New App ListStuffFast to Start "The Conversation" With a Parent That Has No Plan For End-of-Life 3Health News:Many Homeowners Missing Key Safety Risks with Home Heating;Missouri-based Company E and Q Announces New Safety Check 2Health News:Many Homeowners Missing Key Safety Risks with Home Heating;Missouri-based Company E and Q Announces New Safety Check 3Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 2Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 3Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 4Health News:Spinal Surgery Varies by Region in U.S.: Study 2
... Acuo Technologies(R), developers of the market leading high-performance ... tools and services, announces another year of record ... 91% growth over the previous year in sales ... while adding 72 additional implementations of the DICOM ...
... chain honored for accomplishments , ... Dallas (Vocus) March 3, 2009 -- ... Alliance of Greater Cincinnati, was recently announced 2008 Contracting Professional of the ... ,Described as a pioneer in healthcare for more than three decades, Robb ...
... InfuSystem Holdings, Inc. (OTC Bulletin Board: INHI; ... pumps and associated clinical services, today announced financial results ... ended December 31, 2008.Mr. Steve Watkins, chief executive officer, ... in revenue to $9.1 million for the fourth quarter ...
... Promotions and Educating Consumers of the Importance of Eye ... remind families that having healthy eyes and seeing clearly ... Optical announced today the launch of its annual "Family ... throughout the month of March, Sears Optical is encouraging ...
... CorNova, Inc. today announced the addition of Andrew ... The addition increases board membership to 4.(Logo: ... partner of the Medical Solutions Fund of Siemens ... AG. Prior to joining Siemens Venture Capital, ...
... Genoptix, Inc. (Nasdaq: GXDX ), a ... in the Barclays Capital Global Healthcare Conference at the ... 10 - 11, 2009. Dr. Tina Nova, President ... on Tuesday, March 10, 2009 beginning at approximately 2:30pm ...
Cached Medicine News:Health News:Acuo Technologies(R) Announces Another Record Sales and Implementation Growth 2Health News:The Health Alliance's Dennis Robb Announced Contracting Professional of the Year by The Journal of Healthcare Contracting 2Health News:The Health Alliance's Dennis Robb Announced Contracting Professional of the Year by The Journal of Healthcare Contracting 3Health News:The Health Alliance's Dennis Robb Announced Contracting Professional of the Year by The Journal of Healthcare Contracting 4Health News:InfuSystem Holdings Reports 12.9% Revenue Increase and $3.3 Million of Adjusted EBITDA for the Fourth Quarter of 2008 2Health News:InfuSystem Holdings Reports 12.9% Revenue Increase and $3.3 Million of Adjusted EBITDA for the Fourth Quarter of 2008 3Health News:InfuSystem Holdings Reports 12.9% Revenue Increase and $3.3 Million of Adjusted EBITDA for the Fourth Quarter of 2008 4Health News:InfuSystem Holdings Reports 12.9% Revenue Increase and $3.3 Million of Adjusted EBITDA for the Fourth Quarter of 2008 5Health News:InfuSystem Holdings Reports 12.9% Revenue Increase and $3.3 Million of Adjusted EBITDA for the Fourth Quarter of 2008 6Health News:InfuSystem Holdings Reports 12.9% Revenue Increase and $3.3 Million of Adjusted EBITDA for the Fourth Quarter of 2008 7Health News:InfuSystem Holdings Reports 12.9% Revenue Increase and $3.3 Million of Adjusted EBITDA for the Fourth Quarter of 2008 8Health News:InfuSystem Holdings Reports 12.9% Revenue Increase and $3.3 Million of Adjusted EBITDA for the Fourth Quarter of 2008 9Health News:InfuSystem Holdings Reports 12.9% Revenue Increase and $3.3 Million of Adjusted EBITDA for the Fourth Quarter of 2008 10Health News:Sears Optical Celebrates Annual Family Eye Health Month 2Health News:Sears Optical Celebrates Annual Family Eye Health Month 3Health News:CorNova Announces Addition of Andrew T. Jay, D.M.D., M.B.A., to its Board of Directors 2Health News:Genoptix Announces Participation at Barclays Capital Global Healthcare Conference 2
(Date:10/31/2014)... , Oct. 30, 2014 Electronic ... electronic transmission of prescription related information between ... system allows a physician and nurse practitioner ... a medication error occurs during pharmacy operations. ... applications. It provides complete medical lists, conducts ...
(Date:10/31/2014)... Oct. 31, 2014 Though therapies are in ... expected to show an annual increase of 16.2% over ... nearly $1 billion, according to Kalorama Information,s report, ... stem cell therapeutics that have gained or are expected ... "As drug developers tackle ever more complicated conditions, stem ...
(Date:10/30/2014)... Oct. 30, 2014 /CNW/ - Atlantic Canadians will save ... between Canada,s provinces and territories ... President of the Canadian Generic Pharmaceutical Association (CGPA), said ... while speaking at the Atlantic Summit on Healthcare and ... which is being hosted by the Public Policy Forum ...
Breaking Medicine Technology:E-Prescribing Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2Report: Stem Cell Technologies Market Growing 2Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 2Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 3
... 2011 Nektar Therapeutics (Nasdaq: NKTR ) today reported ... Cash, cash equivalents, and investments at September 30, ... 31, 2010. Revenue for the third quarter of ... in the third quarter of 2010 primarily as a result of ...
... NEW YORK, Nov. 2, 2011 JDRF and The Leona ... largest non-government funders of type 1 diabetes (T1D) programs, announced ... a new level of cooperation between the organizations. The goal ... and development to deliver better treatments, devices, and diagnostics for ...
Cached Medicine Technology:Nektar Therapeutics Reports Third Quarter 2011 Financial Results 2Nektar Therapeutics Reports Third Quarter 2011 Financial Results 3Nektar Therapeutics Reports Third Quarter 2011 Financial Results 4Nektar Therapeutics Reports Third Quarter 2011 Financial Results 5Nektar Therapeutics Reports Third Quarter 2011 Financial Results 6Nektar Therapeutics Reports Third Quarter 2011 Financial Results 7Nektar Therapeutics Reports Third Quarter 2011 Financial Results 8JDRF and the Helmsley Charitable Trust Form a Collaboration to Accelerate Innovative Type 1 Diabetes Research and Development 2JDRF and the Helmsley Charitable Trust Form a Collaboration to Accelerate Innovative Type 1 Diabetes Research and Development 3JDRF and the Helmsley Charitable Trust Form a Collaboration to Accelerate Innovative Type 1 Diabetes Research and Development 4
... Wash both 96- and 384-well ... Auto Strip Washer. As a self ... allows for full control of precise ... of a simple squeeze bottle to ...
The EL401 Manual Plate/Strip Washer accommodates all 96-well microplates and microwell strips. The unique alignment mechanism allows quick and accurate positioning of the 8- or 12-channel manifold ab...
... is especially designed for the atraumatic removal ... sleek design of this probe minimizes the ... Due to its 24K gold plating, the ... foreign body incarceration. The magnetic probe is ...
... Designed for flexible continuous monitoring, the ... for adult, pediatric and neonatal patient care. ... Multi-Measurement Server that includes a basic set ... pressure or temperature. Optional Multi-Measurement Server extensions ...
Medicine Products: