Navigation Links
New drug candidate starves dormant cancer cells
Date:2/18/2014

In a study published in Nature Communications, researchers at Karolinska Institutet and Uppsala University in Sweden present a new drug candidate, which selectively kills dormant cells within a cancer tumour through starvation. These tumour cells, which are found in less oxygenated parts of solid tumours, are resistant to conventional treatments.

In solid tumours larger than a few millimetres, there is usually a lack of both oxygen and nutrients due to insufficient blood vessel growth. This in turn results in cancer cells falling into a state of dormancy. After treatment, such dormant cells will start to divide and tumours will grow. This phenomenon therefore contributes to resistance of solid tumour to radio- and chemotherapy.

In their newly published study, the researchers show that cancer cells located in tumour regions that are poorly oxygenated and lack nutrition are unable to compensate for deficient mitochondrial energy production.

"We have identified a small molecule that we call VLX600, which in various in vitro and in vivo models has proven effective against dormant colon cancer cells that are otherwise very difficult to treat. VLX600 is a mild inhibitor of mitochondrial respiration, and we have found that dormant cancer cells have a limited possibility to compensate decreased mitochondrial function by increased glycolysis. The dormant cancer cells therefore die by starvation" says Stig Linder, the professor of experimental oncology leading the study.


'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1

Related medicine news :

1. Maricopa Community Colleges Consider Five Candidates for Top Human Resources Job
2. New drug candidates show promise for cure for Chagas disease
3. Innovative Screening Strategy Swiftly Uncovers New Drug Candidates, New Biology
4. Promising results for Swedish cancer drug candidate
5. Dissertation Pal Introduces Statistics Help for Doctoral Candidates
6. OHSU AIDS vaccine candidate appears to completely clear virus from the body
7. Women's Strike Force Announces First Fund Distribution to Virginia House of Delegates Candidates for November Race
8. Issue III registry defines best syncope candidates for cardiac pacing
9. Genetic variations may help identify best candidates for preventive breast cancer drugs
10. Candidate drug provides benefit in SMA animal models
11. Drugs targeting blood vessels may be candidates for treating Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... March 22, 2017 , ... ... frustrating and this tool bypasses that. Healthcare facilities across the country are ... to offer their clients and hospitals, across the country, an efficient and quick ...
(Date:3/22/2017)... ... March 22, 2017 , ... In ... and print media enterprise focused on cancer patients, cancer centers and advocacy groups, ... special 12-part educational video series, “No Ifs, Ands, or Butts,” that focuses on ...
(Date:3/22/2017)... ... March 22, 2017 , ... Influence Health, ... marketing solutions have enabled Children’s Hospital of The King’s Daughters (CHKD) to achieve ... the value of a digital marketing approach, the 206-bed pediatric teaching hospital in ...
(Date:3/22/2017)... FL (PRWEB) , ... March 22, 2017 , ... An ... mosquitoes could occasionally transmit HIV, reports Leslie Norins, MD, PhD. He says ... cases of domestically transmitted Zika virus and in new infections with HIV. ...
(Date:3/22/2017)... ... 22, 2017 , ... University Orthopedics (UOI) today announced the ... Hand, Upper Extremity and Microvascular Surgery at Newport Hospital. Dr. Bragdon specializes in ... and Hand Surgery. , As the leader of comprehensive orthopedic care in ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... ROCKLAND, Mass. , March 22, 2017 EMD ... Germany , in the U.S. and Canada ... be presented during the poster presentation session at the 65 ... Indian Wells, California on March 24 ... on analyses of a real-world database collected from July 2009 ...
(Date:3/22/2017)... YORK , March 22, 2017 ... ... be difficult, given differing statements by White House officials. Federal ... have legalized marijuana for medical and/or recreational use, and businesses ... Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP), Medical Marijuana, Inc. (OTC: MJNA), ...
(Date:3/22/2017)... SINGAPORE , March 22, 2017 Biosensors International ... innovative medical devices, announced today the enrollment of the first American patient ... Investigational Device Exemption (IDE), which will include sites in the ... , France Germany, Italy , and the ... ...
Breaking Medicine Technology: