Navigation Links
New drug active against most aggressive type of lung cancer cells
Date:7/10/2014

Manchester scientists have shown that a new drug could prove useful in treating small cell lung cancer - the most aggressive form of lung cancer.

Scientists from the Cancer Research UK Manchester Institute, based at The University of Manchester and part of the Manchester Cancer Research Centre, teamed up with experts at AstraZeneca, as part of a collaboration agreed in 2010, to test a drug known as AZD3965 - on small cell lung cancer cells.

The research, published in the journal Clinical Cancer Research, also helps identify which patients are most likely to respond to the treatment.

One treatment approach currently being investigated by cancer scientists is finding drugs that exploit the change in energy production in tumours. In cancer cells there is a switch to using glycolysis, a process that requires less oxygen and produces lactate as a by-product. Certain molecules monocarboxylate transporters (MCTs) are involved in the movement of lactate out of cells and drugs that target MCTs have been shown to stop tumour growth.

The Manchester researchers tested a new drug that targets one of these molecules, MCT1, in lung cancer cells and in mouse models.

Professor Caroline Dive, who led the research, said: "Small cell lung cancer has a dismal prognosis and we have seen little improvement in treatment for many years. More targeted therapies are needed to help those patients whose tumours become resistant to chemotherapy. This new drug AZD3965 is currently in clinical trials, but it has not yet been tested in small cell lung cancer."

The team investigated the sensitivity of small cell lung cancer cells to AZD3965 and showed that in those cells lacking an alternate lactate transporter, MCT4, the drug had an effect. They found that the drug increased the level of lactate in cells and, more importantly, reduced tumour growth.

They then looked at tumour samples taken from lung cancer patients an
'/>"/>

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Most prostate cancer specialists dont recommend active surveillance for low-risk patients
2. Keeping active pays off even in your 70s and 80s
3. A new Kabuto-like nickel catalyst forms bioactive frameworks from phenol derivatives
4. Screen of existing drugs finds compounds active against MERS coronavirus
5. Faster dental treatment with new photoactive molecule
6. Resin infiltration effects in a caries-active environment -- 2 year results
7. Beaumont holds first international congress on underactive bladder
8. Beauty & bacteria: Slim, attractive men have less nasal bacteria than heavy men
9. Attractive professional cyclists are faster
10. PhUSE Working Group Active in Developing Standard Analysis Scripts
11. Rehabilitation Robots, Active Prostheses, and Exoskeletons: Market Shares, Strategies, and Forecasts, Worldwide, 2014 to 2020 New Report Available at ReportsnReports.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... (PRWEB) September 15, 2014 These events ... business requirements are in each state; and how to ... include industry professionals, such as medical marijuana pioneer ... and cannabis business consultant Travis Howard of Shift ... running legal marijuana businesses all over the United States. ...
(Date:9/15/2014)... 15, 2014 Concox , a ... wireless communications equipment, is dedicated to bringing reliable products ... Being the best-seller in Concox’s products, GT06N not only ... customers. GT06N is a mini and original GPS car ... be installed in the shelters on cars or trucks. ...
(Date:9/14/2014)... 14, 2014 Adults who are planning ... Quotes Pros website to find quotes for life insurance ... year at http://quotespros.com/life-insurance.html is now delivering the ... partners that are preparing the rates information for adults ... most U.S. states. As a way to simplify the ...
(Date:9/14/2014)... September 14, 2014 Proper oral care ... from Butte, Mont., found a way to teach children ... patent-pending B LITE toothbrush encourages an effective brushing habit ... full two minutes without overbrushing, eliminating guesswork and promoting ... easy to use, suitable for all children, and producible ...
(Date:9/14/2014)... SUNDAY, Sept. 14, 2014 (HealthDay News) -- Getting enough sleep each ... work due to illness, a new study suggests. The study ... who were followed for an average of seven years. Those ... a night were much more likely to have extended absences from ... risk for taking time off from work due to sickness were ...
Breaking Medicine News(10 mins):Health News:How to Start And Run a Successful Legal Marijuana Business 2Health News:iConcox GPS Vehicle Tracker GT06N Designed for Customers' Security 2Health News:Quotes for Life Insurance Now Offered at New Consumer Portal Online 2Health News:A Good Night's Sleep May Mean a Good Day's Work 2
... Kozhikode have claimed that homeopathy offers a cure for ... several medicines like Uppttorium, Rextokes and Brayonia could effectively ... in the hospital that the Andhra Pradesh Government ... Tamil Nadu and Karnataka were also contemplating similar measures, ...
... is an integral part of health, and assessment of sleep ... to an editorial in the September 18 issue of Archives ... The issue is devoted to studies of sleep and health. ... that sleep serves as an indicator of health and quality ...
... of Similac Infant Formula were off the shelf, after its ... a suspected flaw in the bottle. No repercussions after the ... company has decided to recall the product in order to ... content in the bottle. ,Given below ...
... will soon ban gifts like coffee mugs, notepads, pens ... the Stanford University Medical Center offices.// ,The rules, expected ... physicians and medical students at Stanford University to accept ... representative selling drugs, medical devices or related products. ...
... from the rich countries to achieve the universal goal of ... ,Five times more money is needed to meet the goal ... papers published online by the Lancet today. It coincides with ... Norwegian government. , ,According to Timothy Powell-Jackson and ...
... than 1.6 million U.S. adults are estimated to use ... sleeping, according to the results of a// national survey ... Internal Medicine, a theme issue on sleep. ... difficulty sleeping, also known as insomnia, according to background ...
Cached Medicine News:Health News:Incorporate Sleep Evaluation into Routine Medical Care 2Health News:Pharmaceutical Companies Banned from Giving Gifts at Stanford 2Health News:Pharmaceutical Companies Banned from Giving Gifts at Stanford 3Health News:Pharmaceutical Companies Banned from Giving Gifts at Stanford 4Health News:Child death reduction needs five times more funds 2Health News:About 5 Percent of Adults with Insomnia Use Alternative Therapies 2
(Date:9/12/2014)... , September 12, 2014 ... Market by Application [Beverages (Alcoholic, CSD, Sports & Energy ... Pet Food, Meat & Seafood)], by Material (Aluminum ... by MarketsandMarkets, defines and segments the Food & ... of each application in terms of volumes and ...
(Date:9/12/2014)... , Sept. 12, 2014 /PRNewswire-iReach/ -- 9 th ... 22-24, 2014 – Bethesda, MD ... http://www.fdanews.com/9thInspectionsSummitEarlyBird   Photo - http://photos.prnewswire.com/prnh/20140912/145652 ... for the next inspection than to get a glimpse ... during and after an inspection. Come to ...
(Date:9/12/2014)... 12, 2014 Research and Markets ... "Global Medical Technologies Market 2014-2018" report to ... a collective term for software solutions, medical devices, ... health. The Global Medical Technologies market covers active ... In vitro diagnostics technology, dental technology, electromechanical medical ...
Breaking Medicine Technology:Food & Beverage Metal Cans Market Worth $49.20 Billion by 2019 2Food & Beverage Metal Cans Market Worth $49.20 Billion by 2019 3Food & Beverage Metal Cans Market Worth $49.20 Billion by 2019 4FDAnews Announces: Early Bird Registration Discount Ends Sept.19 for 9th Annual Inspections Summit, Oct. 22-24, 2014 2FDAnews Announces: Early Bird Registration Discount Ends Sept.19 for 9th Annual Inspections Summit, Oct. 22-24, 2014 3Global Medical Technologies Market 2014-2018: Key Vendors are GE, Johnson & Johnson, Medtronic, Roche and Siemens 2Global Medical Technologies Market 2014-2018: Key Vendors are GE, Johnson & Johnson, Medtronic, Roche and Siemens 3
... and CAMPBELL, Calif. , May ... sophisticated risk characterization and personalized therapy guidelines for ... of advanced tests, offering an accompanying nutrition program, ... Director stated:  "With appropriate risk characterization and treatment, ...
... May 25 The U.S. Food and Drug Administration approved Lumizyme (alglucosidase ... a rare genetic disorder. , , ... http://www.newscom.com/cgi-bin/prnh/20090824/FDALOGO ) , , , ... an estimated 1 in every 40,000 to 300,000 births. Its primary symptom is ...
Cached Medicine Technology:Health Network Laboratories (HNL) Enters Into License Agreement With Hunter Laboratories to Provide HunterHeart Cardiovascular Disease Management Program. 2FDA Approves New Treatment for Late-Onset Pompe Disease 2FDA Approves New Treatment for Late-Onset Pompe Disease 3
... PoliPhase® is a biologically based ... two component system consisting of a ... the control of internal bleeding. ... readily flow on to a prepared ...
The DuraSeal System includes an innovative polyethylene glycol hydrogel sealant and applicator packaged in a single-use kit which can be stored at room temperature for convenience and quick preparati...
... DERMABOND* Topical Skin Adhesive gives you ... adhesive is intended for topical application only ... of wounds from surgical incisions, including punctures ... cleansed, trauma-induced lacerations. DERMABOND adhesive may be ...
... BD Cell-Tak™ Cell and Tissue Adhesive is ... Mytilus edulis (marine mussel). These proteins are ... by the mussel to anchor itself to ... Cell-Tak Cell and Tissue Adhesive is used ...
Medicine Products: