Navigation Links
New drug active against most aggressive type of lung cancer cells
Date:7/10/2014

Manchester scientists have shown that a new drug could prove useful in treating small cell lung cancer - the most aggressive form of lung cancer.

Scientists from the Cancer Research UK Manchester Institute, based at The University of Manchester and part of the Manchester Cancer Research Centre, teamed up with experts at AstraZeneca, as part of a collaboration agreed in 2010, to test a drug known as AZD3965 - on small cell lung cancer cells.

The research, published in the journal Clinical Cancer Research, also helps identify which patients are most likely to respond to the treatment.

One treatment approach currently being investigated by cancer scientists is finding drugs that exploit the change in energy production in tumours. In cancer cells there is a switch to using glycolysis, a process that requires less oxygen and produces lactate as a by-product. Certain molecules monocarboxylate transporters (MCTs) are involved in the movement of lactate out of cells and drugs that target MCTs have been shown to stop tumour growth.

The Manchester researchers tested a new drug that targets one of these molecules, MCT1, in lung cancer cells and in mouse models.

Professor Caroline Dive, who led the research, said: "Small cell lung cancer has a dismal prognosis and we have seen little improvement in treatment for many years. More targeted therapies are needed to help those patients whose tumours become resistant to chemotherapy. This new drug AZD3965 is currently in clinical trials, but it has not yet been tested in small cell lung cancer."

The team investigated the sensitivity of small cell lung cancer cells to AZD3965 and showed that in those cells lacking an alternate lactate transporter, MCT4, the drug had an effect. They found that the drug increased the level of lactate in cells and, more importantly, reduced tumour growth.

They then looked at tumour samples taken from lung cancer patients and found that high levels of MCT1 were linked to worse patient prognosis.

Professor Dive added: "We propose that this drug will be most useful in this subset of patients who have elevated MCT1 levels and need more effective treatments.

"Our laboratory results are promising and certainly provide encouragement to test this treatment clinically in patients with small cell lung cancer."

Susan Galbraith, head of the oncology innovative medicines unit at AstraZeneca, said: "Lung cancer is still the leading cancer killer, and we are working on a number of potential treatment options that could provide patients with a better chance of beating the disease. Targeting tumour cell metabolism represents a novel and exciting approach, and we are delighted to be working with The University of Manchester and Cancer Research UK to investigate the utility of AZD 3965 as a potential novel cancer treatment."


'/>"/>

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Related medicine news :

1. Most prostate cancer specialists dont recommend active surveillance for low-risk patients
2. Keeping active pays off even in your 70s and 80s
3. A new Kabuto-like nickel catalyst forms bioactive frameworks from phenol derivatives
4. Screen of existing drugs finds compounds active against MERS coronavirus
5. Faster dental treatment with new photoactive molecule
6. Resin infiltration effects in a caries-active environment -- 2 year results
7. Beaumont holds first international congress on underactive bladder
8. Beauty & bacteria: Slim, attractive men have less nasal bacteria than heavy men
9. Attractive professional cyclists are faster
10. PhUSE Working Group Active in Developing Standard Analysis Scripts
11. Rehabilitation Robots, Active Prostheses, and Exoskeletons: Market Shares, Strategies, and Forecasts, Worldwide, 2014 to 2020 New Report Available at ReportsnReports.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2017)... Los Angeles, California (PRWEB) , ... May 26, 2017 , ... ... Canadian senior citizens who visit a doctor for colds or respiratory issues that are ... note that excessive time pressure on doctors may be largely responsible for the problem ...
(Date:5/27/2017)... Rosa, CA (PRWEB) , ... May 27, 2017 , ... ... cause for concern, but a new study from the Osteoarthritis Initiative shows ... to developing knee osteoarthritis. Knowing this in advance may give doctors the opportunity to ...
(Date:5/26/2017)... Fairfax, VA (PRWEB) , ... May 26, 2017 ... ... is pleased to announce a new educational seminar to focus on current legislative ... Regulatory News(LEARN) seminar will begin at 1 p.m. Sunday, Sept. 10, and will ...
(Date:5/26/2017)... ... 26, 2017 , ... Boar’s Head Brand®, one of the ... Day entertaining that are sure to satisfy your guests’ flavor cravings, while adding ... cheeses featured in these refreshingly balanced recipes are packed with flavor, creating the ...
(Date:5/26/2017)... ... May 26, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... focusing on the Peace Agreements being discussed by President Donald Trump and the rest ... to try to speed up peace talks in the continuous battle between Israel and ...
Breaking Medicine News(10 mins):
(Date:5/8/2017)... May 8, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO)., ... ("WRB"), a health care service center company based ... WRB specializes in relationship management programs for leading pharmaceutical ... WRB will join Envoy Health ... services for manufacturers, biotech firms, and other service companies. ...
(Date:5/4/2017)... Tenn. , May 4, 2017  A ... Infection Control, Ultraviolet-C light as a ... Tru-D SmartUVC,s ability to reduce bioburden on anesthesia ... bioburden reduction on high-touch, complex medical equipment surfaces ... surgical infections. "This study further validates ...
(Date:5/4/2017)...   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade hypothermic storage and ... announced that the Company,s first quarter 2017 financial results ... 11, 2017, and that the Company will host a ... that afternoon. Management will provide an overview of the ...
Breaking Medicine Technology: