Navigation Links
New discovery proves cause of weight problems in Huntington's disease

The study, which has been published in the scientific journal Cell Metabolism, shows significant changes in the brain's hormone control centre, the hypothalamus. In a series of experiments on mice, which had the mutated Huntington's protein injected into this area of their brains, the animals soon demonstrated a reduced ability to regulate their metabolism.

"With the selectively produced mutated protein, we saw immediate changes; the mice started to eat more and became very fat. We have now been able to prove that there is a causal relationship between this mutated protein in the hypothalamus and weight gain. The changes we see in the mice's brains are similar to those we have previously observed in the brains of Huntington's patients", says doctor and researcher sa Petersn at Lund University.

The effects of the mutated Huntington's protein disable the normal control of blood sugar levels in the body. It is probable that a resistance to insulin is developed, which makes some nerve cells deaf to important signals. This stops the complex metabolic system working.

The research group has previously shown that the pathological changes in the hypothalamus begin up to ten years before the movement problems are seen. This means that new treatments targeted at the small communications control centre, the hypothalamus, could provide relief to Huntington's patients at a much earlier stage.

One of the most promising treatments that are currently being researched aims to 'turn off' the mutated Huntington's gene. The research group in Lund has successfully tested the method on mice, with the result that they stopped developing irregularities in their metabolism.

"Our idea is to turn off the mutated gene in the hypothalamus. The problem is that we don't want to turn off the normal Huntingtin gene, which still has an important function. We now hope to be able to refine our method and focus specifically on the mutated Huntingtin", says sa Petersn.

The newly discovered changes in the hypothalamus in Huntington's disease are a growing research field. The targets for new treatments are non-motor symptoms such as weight problems, sleeping problems and depression.


Contact: sa Petersen
Lund University

Related medicine news :

1. UCSF Enters Drug Discovery Agreement with Genentech
2. UCSF enters drug discovery agreement with Genentech
3. New discovery: Plaice are spotted (on the inside)
4. SeqWright Advances Genomic Discovery With Isilon IQ
5. Effective prostate cancer treatment discovery
6. Co-Creator of Six Sigma Unveils “The Great Discovery” ... the 4th Generation of Six Sigma
7. U discovery gives insight into brain replay process
8. Discovery of cellular switch may provide new means of triggering cell death, treating disease
9. Discovery May Lead to Better Multiple Sclerosis Treatments
10. Astrogenetix Narrows in on MRSA Virulence Onboard Discovery
11. TGen Drug Development partners with Horizon Discovery for integrated personalized medicine service
Post Your Comments:
(Date:11/27/2015)... ... 27, 2015 , ... The men and women on this ... in the country. They have overseen financial turnarounds, shown commitment to their community ... industry as a whole through their advocacy and professional efforts. , Becker's Hospital ...
(Date:11/27/2015)... ... November 27, 2015 , ... Indosoft Inc., developer ... incorporation of Asterisk 11 LTS (Long Term Support) into its Q-Suite 5.10 product ... Q-Suite 5.10 up-to-date with a version of Asterisk that will receive not only ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... ... a real-time eReferral system for diagnostic imaging in the Waterloo region. Using the ... and Nuclear Medicine tests directly from their electronic medical record (EMR) without the ...
(Date:11/26/2015)... ... November 26, 2015 , ... Jobs in hospital medical laboratories and ... offered by healthcare staffing agency Aureus Medical Group . These fields, ... 2015 among those searching for healthcare jobs through the company’s website, ...
(Date:11/26/2015)... CA (PRWEB) , ... November 26, 2015 , ... ... a new set of retro-fused, self-animating trailer titles with ProTrailer: Vintage. This newly ... options. These classically-influenced trailer titles work with any font, giving users limitless opportunities ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 /PRNewswire/ ... announced the addition of the "Global ... to their offering. --> ... "Global Brain Monitoring Devices Market 2015-2019" ... Research and Markets ( ) ...
(Date:11/25/2015)... Nov. 25, 2015  Linden Care, LLC, a retail ... outcomes for patients suffering from chronic pain, said today ... Temporary Restraining Order (TRO) enjoining Express Scripts from unilaterally ... --> --> The ... its legal options. --> ...
(Date:11/25/2015)... 25, 2015  Henry Schein, Inc., the world,s largest ... dental, medical and animal health practitioners, will unveil at ... Henry Schein ConnectDental® Pavilion , which brings together for ... solutions designed to help any practice or laboratory enter ... for a schedule of experts appearing at the Pavilion. ...
Breaking Medicine Technology: