Navigation Links
New discovery permits rapid diagnosis and treatment of sepsis
Date:5/30/2013

Bethesda, MDDespite numerous advances in treating infections and disease, effective treatments for sepsis remain elusive. A new discovery published in the June 2013 issue of The FASEB Journal not only could help health care providers predict who is more and less likely to develop sepsis, but it also opens the doors to new therapies that actually address the root cause of the problem, rather than just managing the symptoms. This also has the potential to benefit patients suffering from influenza and other viral infections, as well as chronic inflammatory diseases such as periodontal disease, rheumatoid arthritis, inflammatory bowel disease and chronic obstructive pulmonary disease.

"Addressing infectious and inflammatory complications early and effectively in burn and trauma patients remains a significant unmet clinical need," said Daniel Irimia, M.D., Ph.D., a researcher involved in the work from the BioMEMS Resource Center and the Department of Surgery at Shriners Hospital for Children in Boston, MA. "This need is augmented by the difficulties of diagnosing infections early and the upsurge in frequency of multi-drug resistant bacteria."

To make this discovery, Irimia and colleagues studied two groups of rats with burn injuries and septic complications by designing a microfluidic assay to precisely measure the movement of isolated neutrophils. They found that the ability of neutrophils to move becomes progressively worse during the first week after the injury, and that a known compound, called resolvin D2, can restore neutrophil movement. Using neutrophil measurements as a guide, researchers optimized the parameters of the treatment, and as a result all treated animals survived, while all untreated animals died. This study suggests that measuring neutrophil motility could become a useful biomarker for the actual risk for septic complications in patients. Rather than relying on statistical data for each disease and patient group, measuring neutrophil movement could help personalize treatments for individual patients, resulting in better outcomes.

"Reports of patients contracting deadly secondary infections while in the ICU continue to increase," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "but doctors have to find out what's wrong, and find it out quickly. This research should lead to faster diagnosis and better treatments for burns and sepsis. It's an important step on the way to new therapeutics."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
2. Washingtons Life Sciences Discovery Fund awards commercialization grants
3. Discovery could help to develop drugs for organ transplant and cancer patients
4. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
5. H1N1 discovery paves way for universal flu vaccine: UBC research
6. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
7. Researchers make promising discovery in pursuit of effective lymphoma treatments
8. Discovery suggests new combination therapy strategy for basal-like breast cancers
9. Discovery of Gene May Lead to New Male Contraceptive
10. 5 more pharmaceutical companies join NIH initiative to speed therapeutic discovery
11. Illnesses in Colorado childrens hospital prompts discovery of contaminated alcohol pads
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... As health professionals work to improve their approach to healthcare, ... doing more than filling out a survey; in many cases health professionals and patients ... health care and research on the importance of active engagement with patients and members ...
(Date:10/13/2017)... ... 2017 , ... PurhealthRX , a leading Health and Nutrition Company, is ... to full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing ... easily incorporated into liquid products, while reducing costs to end users. , The team ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Many families have ... many long-term care insurance companies have a waiver for care if the client has ... period, when the family pays for care, is often waived, so the benefits from ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the ... published author, William Nowers. Captain Nowers and his wife, Millie, have six children, ... in the Navy. Following his career as a naval aviator and carrier pilot, ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Oct. 11, 2017  True Health, a leader ... its effort during National Breast Cancer Awareness month ... risks. Research ... calculated that more than 10 million American women ... in BRCA1 or BRCA2 and have not had testing. ...
(Date:10/5/2017)... 2017  In response to the nationwide opioid ... Surgeons (AAOMS) released prescribing recommendations that urge ibuprofen ... as a first-line therapy to manage a patient,s ... Recognizing the value and importance of ... Prescribing: Acute and Postoperative Pain Management" stresses that ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: