Navigation Links
New discovery of proteins involved in positioning muscular nuclei
Date:3/20/2012

In order to move, living beings need muscles, and, more specifically, skeletal muscles that are controlled by the nervous system. Skeletal muscles are composed of cylindrical muscle fibres with a multitude of peripheral nuclei. Until now, little was known about the mechanism used to position nuclei on the edge of muscle fibres. A team of French-American researchers has tried to better understand the reasons behind nuclei layout.

Edgar Gomes and his team of collaborators have identified the mechanism involved in positioning nuclei in muscle fibres. The researchers identified (in Drosophila and mice) two proteins involved in positioning the nuclei: protein Kif5B, which belongs to the kinesin family (molecular motor), and protein MAP7, which is used to move different organelles in cells.

This result was achieved by mutating MAP7 and Kif5b protein-coding genes in the Drosophila and by studying the development of the embryo. In this case, they observed that the nuclei were not correctly aligned in the muscle fibres.

"MAP7 is required to position nuclei in muscle fibre in Drosophila and in mammals" states Edgar Gomes, Inserm researcher. The research team succeeded in describing the nuclei-positioning mechanism in fibres, which involved the MAP7 protein and its interaction with the molecular motor: kinsin Kif5b. They demonstrated that a mutation of these proteins did not affect muscle extension or its attachment to the skeleton: only the position of the nuclei was affected.

By making both proteins interact together, Edgar Gomes' team suggest that MAP7 binds with Kif5b to encourage nuclei positioning. "Furthermore, these proteins act together, both physically and genetically, and their physical bond is required for correct nuclei positioning. Our results show that they are required for the muscle to function correctly" underlines Edgar Gomes.

Muscular diseases lead to weaknesses in the fibres and can be associated with a cellular nuclei alignment failure. Edgar Gomes and his team have demonstrated that by correctly replacing the nuclei, the muscle recovers its functions. "We suggest that by correcting muscular positioning faults in patients suffering from myopathies, these patients may see improvements in their muscular functioning" concludes Edgar Gomes.


'/>"/>

Contact: Inserm Presse
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Related medicine news :

1. UCSF Enters Drug Discovery Agreement with Genentech
2. UCSF enters drug discovery agreement with Genentech
3. New discovery: Plaice are spotted (on the inside)
4. SeqWright Advances Genomic Discovery With Isilon IQ
5. Effective prostate cancer treatment discovery
6. Co-Creator of Six Sigma Unveils “The Great Discovery” ... the 4th Generation of Six Sigma
7. U discovery gives insight into brain replay process
8. Discovery of cellular switch may provide new means of triggering cell death, treating disease
9. Discovery May Lead to Better Multiple Sclerosis Treatments
10. Astrogenetix Narrows in on MRSA Virulence Onboard Discovery
11. TGen Drug Development partners with Horizon Discovery for integrated personalized medicine service
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/12/2020)... ... January 11, 2020 , ... The co-founder and CEO of ... with the annual JP Morgan Healthcare Conference. On Sunday, January 12, Sujuan Ba, ... technology company investors and advisers at the San Francisco office of international law ...
(Date:1/10/2020)... ... January 10, 2020 , ... Sigma Theta Tau International Honor ... of the Year Awards. These awards are regarded as one of the most important ... the AJN Book of the Year competition has recognized Sigma for the last 11 ...
(Date:1/10/2020)... ... January 10, 2020 , ... ... of autoimmune conditions, HMP, a leading healthcare event and education company, today announced ... patient care. , The Autoimmune Learning Network serves as a robust digital hub ...
(Date:1/10/2020)... , ... January 10, 2020 , ... ... in Portland, Oregon, provides a friendly, non-intimidating environment for all women. In search ... Habits to its current and prospective members. , For nearly 30 years, ...
(Date:1/8/2020)... ... 08, 2020 , ... Myant Inc., leaders in Textile Computing™, ... by the Myant Platform at CES 2020, happening January 7-10, in Las ... the Myant Platform will be aware of the worker’s current physical and psychological ...
Breaking Medicine News(10 mins):
(Date:1/7/2020)... (PRWEB) , ... January 07, 2020 , ... ... first calibration-free blood pressure (BP) sensor system for integration in hearables and wearables. ... device and consumer electronics manufacturers for inclusion in their products. Embedded in an ...
(Date:1/7/2020)... ... January 07, 2020 , ... ... Tuesday, Jan. 21, 2020, 11:00 a.m.-12:30 p.m. EST, https://www.fdanews.com/chinanpma , China ... It is the only market with a 20 percent annual growth rate year ...
(Date:1/3/2020)... ... 2020 , ... In Partnership with the Smiles for Everyone Foundation , ... its Burleson, TX office on February 8th. , Dental services provided include same-day procedures ... extractions . For more information, please visit the Monarch Dental website . ...
Breaking Medicine Technology: