Navigation Links
New discovery may improve treatment of one of the world's leading causes of blindness
Date:9/28/2007

fellow Umesh Yadav, took a different route to reduce inflammation, building on work Srivastavas group has already successfully applied to fighting colon cancer and sepsis in animal experiments. Working with rats that had been injected with a uveitis-generating bacterial toxin, they demonstrated that the eye-damaging inflammation could be stopped by treatment with a compound that blocks the action of aldose reductase, an enzyme essential to the production of inflammatory signaling molecules.

We measured inflammatory markers in the untreated rats eyes during inflammation there are a lot of inflammatory signaling proteins and inflammatory cells secreted in the aqueous humor, the clear liquid inside the eyes, Ramana said. The concentrations of those proteins and cells are much lower when we used the aldose reductase inhibitor. When we also studied different sections of the eyes of rats treated with aldose reductase inhibitor, for example the retinal region, we saw the same reduction in the signaling molecules that cause damaging inflammation.

The specific aldose reductase inhibitor used in the experiments was zopolrestat, which is currently in phase 3 clinical trials as a treatment for diabetic complications. But Srivastava said the same effect would likely be produced by other aldose reductase inhibitors, including one now approved for use in Japan.

We have not reached the clinical trial stage as yet, but we are not far away, Srivastava said. If the trials work out, wed like to go for topical administration in drops, which would mean that only the tissues of the eye would be affected by the drug.


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. OHSU Researchers Announce New Discovery
2. Discovery of bone gene
3. Latest discovery on Autism
4. Bacterial discovery may help CF patients
5. A new discovery about Acetaminophen
6. A new discovery about Acetaminophen
7. Resistant tumors could be treated with the discovery of a new molecule within cancer cells
8. Treatment for cholesterol-related illnesses likely with the discovery of receptor in mice
9. Ways to counter radiation effects with new molecule discovery
10. Canada stunned as mad cow discovery leads to beef ban
11. Mouth Infection better handled with new discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... , ... August 01, 2015 , ... Tina Wilcoxson, owner ... , Wilcoxson was given that honor by the National Retail Federation, the largest retail ... Wilcoxson was one of three Maine business owners to be named as such. According ...
(Date:8/1/2015)... ... 01, 2015 , ... BeverlyD, owner and founder of BeverlyD Luxe Organic Hair ... first small business donation to kick off the campaign for healing and Well-Being. , ... includes a complete line of raw, organic hair care products, as well as her ...
(Date:7/31/2015)... New York, New York (PRWEB) , ... July 31, 2015 , ... ... started to strut their stuff, Super-Sod debuted their new type of sod called ... with registered trademark application in process. , To commemorate introduction of this new type ...
(Date:7/31/2015)... ... July 31, 2015 , ... Recently touted by ... predictive health analytics , Jvion continues to disrupt the predictive analytic and ... that targets patient and population level illness to drive prevention and better health ...
(Date:7/31/2015)... ... July 31, 2015 , ... Jacksonville-based drug and alcohol rehabilitation ... Conference Center. The medical community, social workers, law enforcement, and government officials are ... in the effort to better understand and combat sex trafficking. Lead by sex ...
Breaking Medicine News(10 mins):Health News:Local Retail Advocate Wins National Recognition 2Health News:March4thforWellBeing Foundation Kickoff 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3
... with HIV/AIDS have opposed a patent application filed by ... combination AIDS drug on the grounds that it would ... by the Lawyers' Collective HIV/AIDS Unit, the Indian Network ... of Positive People Thursday officially submitted their opposition to ...
... from Duke University Medical Center and John Hopkins University ... signaling pathway that plays a vital role in the ... injury lead to the development of liver cancer. ... in immature, stem-like liver cells. This discovery could lead ...
... to propagate a new method of sex education for youngsters ... with the China Family Planning Association, said: 'Puberty and child-bearing ... is lagging behind.' ,China now has more than ... million become sexually mature each year. ,Education ...
... an alarming rise in obesity among city kids in Britain, increasing ... 37% of the urban kids really walk to school as compared ... of the kids spend almost 4 hrs sedentarily, watching television or ... of Type 2 diabetes, which was common only in the above ...
... using tissue cultures suggests, that a pain killing medication helps ... to a common form of breast cancer. The name of ... labs experiments on breast cancer cells, scientists found that derivatives ... in estrogen-dependent breast cancer. This form of cancer is the ...
... Hopkins joined the aid efforts by identifying more than ... // The devastating natural disaster, which hit Louisiana and ... Even though most of victims were identified by their ... analysis. ,Using experience gained in DNA analysis of ...
Cached Medicine News:Health News:HIV Patients Opposes Patenting Of AIDS Drug 2Health News:Unchecked Cellular Repair Pathway Causes Liver Cancer 2Health News:Pain-killer Drug Can Help Fight Breast Cancer 2Health News:Genetic Experts of Hopkins Assists In Identifying Hurricane Katrina Victims 2Health News:Genetic Experts of Hopkins Assists In Identifying Hurricane Katrina Victims 3
(Date:7/31/2015)... Pa. , July 31, 2015 ... fully integrated specialty pharmaceutical company focused on developing, ... the closing of its previously announced underwritten public ... at a public offering price of $11.25 per ... offering included 1,000,000 shares issued upon the exercise ...
(Date:7/31/2015)... and SAN DIEGO , ... its parent company Eisai Co., Ltd. (Headquarters: ... , "Eisai") and Halozyme Therapeutics, Inc. (Headquarters: ... Helen Torley , "NASDAQ: HALO") have signed a ... name: Halaven ® , "eribulin") in combination with Halozyme,s ...
(Date:7/31/2015)... According to a new market ... Analyzers (BIA), Dual-Energy X-ray Absorptiometry (DEXA), Skinfold Calipers, Air ... & Forecast to 2019", published by MarketsandMarkets, the global ... 2014 and is estimated to grow to $1,425.7 Million ... 2014 to 2019. Browse 41 market ...
Breaking Medicine Technology:Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 2Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 5Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 6Body Composition Analyzers Market Worth $1,425.7 Million by 2019 2Body Composition Analyzers Market Worth $1,425.7 Million by 2019 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 4
... June 16, 2011 Reportlinker.com announces that a ... catalogue: UK CT Systems – ... http://www.reportlinker.com/p0555197/UK-CT-Systems-–-Market-Trend-Till-2016.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Imaging Short Description ... data on the CT systems in UK. It ...
... Inc., a leading provider of software solutions to ... today announced that a number of pharmaceutical industry ... participate in the creation of a set of ... performance data. Each of the initial sponsors will ...
Cached Medicine Technology:Reportlinker Adds UK CT Systems - Market Trend Till 2016 2DecisionView to Create Clinical Trial Enrollment Benchmarks 2DecisionView to Create Clinical Trial Enrollment Benchmarks 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: