Navigation Links
New discovery in fight against deadly meningococcal disease
Date:5/23/2013

"Neisseria meningitidis is an important human pathogen that can cause rapidly progressing, life threatening meningitis and meningococcal sepsis in humans," Professor Jennings said.

"Until now we have not known how it attaches to the human host. It has been a long-standing mystery how it attaches to the airway to colonise"

People can be carriers of the bug and not get any symptoms, while some people progress to invasive disease. To understand why, we need to know the detail of how the bacterium colonises the airway. Now that the pathway has been identified we can study this process to understand how invasive disease occurs. This is especially important considering the rapidly progressing and serious outcomes of meningococcal disease.

"If you understand how the bug first attaches and how it first signals its attachment then we may identify new risk factors or treatment procedures," Professor Jennings said.

The findings were published Friday in the highly regard PLOS Pathogens journal as featured research "Dual Pili Post-translational Modifications Synergize to Mediate Meningococcal Adherence to Platelet Activating Factor Receptor on Human Airway Cells."

The paper states: There is no fully protective vaccine against this pathogen in current use and the key processes that dictate the transition from harmless carriage of the bacterium in the airway (the case for the vast majority of colonised hosts) to invasive disease are largely undefined. A key missing link in this organism's interaction with the human host is the identity of the receptor that is the first point of contact for the organism within the airway.

Professor Jennings said the receptor is used by a range of airway pathogens and the bacterium mimics a human structure to attach to this receptor.

"It's not actually protein that attaches to the receptor but decorations on the protein that are known as post-translational modifications. One of these is a sugar structure, which of course is of great interest to our work here at Glycomics," he said.

The Institute of Glycomics is a world leader in the study of glycans and carbohydrates (sugars) and how they behave in terms of disease prevention and cure.


'/>"/>

Contact: Helen Wright
helen.wright@griffith.edu.au
047-840-6565
Griffith University
Source:Eurekalert

Related medicine news :

1. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
2. Washingtons Life Sciences Discovery Fund awards commercialization grants
3. Discovery could help to develop drugs for organ transplant and cancer patients
4. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
5. H1N1 discovery paves way for universal flu vaccine: UBC research
6. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
7. Researchers make promising discovery in pursuit of effective lymphoma treatments
8. Discovery suggests new combination therapy strategy for basal-like breast cancers
9. Discovery of Gene May Lead to New Male Contraceptive
10. 5 more pharmaceutical companies join NIH initiative to speed therapeutic discovery
11. Illnesses in Colorado childrens hospital prompts discovery of contaminated alcohol pads
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2017)... Fla. (PRWEB) , ... June 24, 2017 , ... ... is now offering genetic testing for medications in select Florida and Texas doctors' ... pharmacogenomics. , This new application of genetic testing recognizes the role genes ...
(Date:6/24/2017)... , ... June 24, 2017 , ... The weather is ... time outdoors. Home and business owners should be aware that the summer months provide ... In fact, mechanical locks and keys can be negatively affected from direct exposure to ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... and will ultimately do significant harm to people with all chronic conditions, including ... "While it leaves in place the Affordable Care Act (ACA) requirement that insurers ...
(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that carotenoids and ... of visual loss in these patients. , But how often do ophthalmologists and optometrists ... to patients at risk of or with early symptoms of AMD? A study ...
(Date:6/23/2017)... ... 2017 , ... Military Connection friend and veteran advocate Micaela Bensko ... Atlantic lounge. , Bensko is no stranger to the plight of the disabled. ... life to supporting our wounded veterans. A world-class photographer, her riveting photos “The Wounds ...
Breaking Medicine News(10 mins):
(Date:5/26/2017)...  In response to the opioid epidemic in ... working with Pfizer to make up to 1 million ... community health centers, free and charitable clinics, public health ... "Pfizer has a long-standing commitment to improving health outcomes ... through educational activities," said Caroline Roan , vice ...
(Date:5/23/2017)... Calif. , May 23, 2017  Leaf ... most innovative medical devices for pressure ulcer prevention, ... the American Association of Critical Care Nurses, National ... May 22-25. The Leaf Patient Monitoring ... specifically for the hospital environment.  The system seamlessly ...
(Date:5/22/2017)... , May 22, 2017  As the ... a whole continue to make the revolutionary shift ... increasingly important for ensuring positive patient outcomes and ... stakeholders are shifting focus away from clinical trials ... effects of long-term specialty drug therapy utilization in ...
Breaking Medicine Technology: