Navigation Links
New discovery gives tuberculosis vaccine a shot in the arm
Date:2/26/2009

A new article appearing in the March 2009 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) may lead to improvements in the efficacy of the current tuberculosis vaccine. Specifically, a team of Italian researchers discovered a new role for type I interferon, in which it improves the ability of dendritic cells to stimulate an immune response against the bacterium known to cause tuberculosis. The researchers speculate that type I interferon may give the current vaccine the "boost" necessary to elicit a protective immunity against the mycobacterium tuberculosis.

"The results from our work on the novel role of type I interferons should open new perspectives in their use as a vaccine adjuvant," said Eliana M. Coccia, the senior researcher involved in the work.

Coccia and her colleagues made this discovery by obtaining human dendritic cells from the blood of healthy volunteers. The cells were divided in two groups: one of which was left untreated while the other was stimulated with type I interferon (IFN-beta). After four hours, both groups were treated with the tuberculosis vaccine. A day later, the researchers analyzed the cells and found that those pretreated with type I interferon had improved function over those from the untreated group. This suggests that type I interferon may play a role in improving the vaccine's ability to prevent tuberculosis.

"Because advances in research, medicine, and technology seem to happen on a daily basis, it's easy to forget that people still struggle against diseases like tuberculosis," said E. John Wherry, Deputy Editor of the Journal of Leukocyte Biology. "The finding described in this study suggest that type I interferon, an immune modulator normally associated with viral infections, could have great clinical benefit for people suffering from tuberculosis."

According to the U.S. Centers for Disease Control and Prevention, one third of the world's population is infected with the tuberculosis, with nearly 9 million people getting sick with the disease each year. Of those 9 million, almost 2 million die. The disease can spread through the air, and it usually affects the lungs. Without treatment, tuberculosis is fatal. The BCG vaccine for tuberculosis is used in many countries, but not generally recommended in the United States. The vaccine is not completely effective in preventing tuberculosis, making it imperative for scientists to find ways to improve its efficacy.


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. National Organization for Rare Disorders To Partner With Discovery Health and MYSTERY DIAGNOSIS for Rare Disease Day 2009
2. GlycoMeds Discovery Yields Early Warning Test for Cancer
3. MDS Analytical Technologies Laser Capture Microdissection Helps Facilitate Discovery of Potential New Colon-Cancer Biomarker
4. Discovery Health Uncovers the Truth With Its Mystery March Programming Event
5. This February Discovery en Espanol Delves Into The Subconscious World of Attraction in Science of Sex Appeal
6. Cancer-Causing Gene Discovery Suggests New Therapies
7. The 2009 Damon Runyon-Rachleff Innovation Award Granted for Pioneering Ideas for Early Detection of Ovarian and Lung Cancers, Bone Marrow Transplant Safety, and Discovery of New Genetic Markers for Cancer
8. Zassi Medical Evolutions Launches New Online Company That Uses Business DNA to Deliver Advanced Discovery, Collaboration, and Business Intelligence Tools to the Medical Device Industry
9. American Asthma Foundation Announces Breakthrough Discovery
10. Life Sciences Discovery awards health research program grants
11. MaxCyte Presents a Panel Discussion With Industry Experts on the Challenges in Developing Cell-Based Screening Assays for Drug Discovery - LIVE Q&A to Follow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... ... January 16, 2017 , ... Houston dentist, Dr. Behzad ... offering complimentary consultations and financing for orthodontics for a limited time. Complimentary for ... learn about their orthodontic options. Walk-in, late-evening, Saturday, and same-day appointments are available. ...
(Date:1/16/2017)... ... January 16, 2017 , ... Specialty Technical Publishers (STP) ... Audit Protocol Consortium (IAPC) EHS audit protocol for Singapore . Leading companies ... their EHS regulatory obligations and rapidly collect, share, archive, and export audit findings ...
(Date:1/16/2017)... , ... January 16, 2017 , ... ... attorney, science teacher, http://www.ageofautism.com/legal , Sharon Kleyne, America’s leading water educator, ... to her nationally syndicated radio program, The Sharon Kleyne Hour Power of Water, ...
(Date:1/16/2017)... ... 2017 , ... One thing common to all types of cancer is that ... well. The money spent screening for and treating cancer in the United States is ... cancer more than in any other country that has an advanced healthcare system, sometimes ...
(Date:1/16/2017)... ... January 16, 2017 , ... NexTec Group has been selected as ... organizations honored for their accomplishments in the field of midmarket financial software. , Members ... recognition, and innovation. Selection is not based on revenue and those firms chosen represent ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... , Jan. 16, 2017 Infusion ... devices used for administering medications in a controlled, ... used for therapeutic purposes in critical care, pain ... required to make patient,s feel comfortable and pain ... errors which would lead to serious life threatening ...
(Date:1/16/2017)... 2017 Derek H. Potts , founder ... recently appointed Liaison Counsel in California,s ... cases. In this role, Potts was assigned to serve ... assist the Court and Co Lead Plaintiff,s Counsel. Co-Counsel ... Jackson Fairchild & Wade and Ruth Rizkalla ...
(Date:1/16/2017)... TORONTO , Jan. 16, 2017 When synthetic ... to market their product as top-rate. They offered free samples, ... top-notch customer service. Soon, business was booming. ... often described as 100 times more powerful than morphine, has ... in last 2 years. One dealer,s recorded fentanyl ...
Breaking Medicine Technology: