Navigation Links
New discovery gives tuberculosis vaccine a shot in the arm
Date:2/26/2009

A new article appearing in the March 2009 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) may lead to improvements in the efficacy of the current tuberculosis vaccine. Specifically, a team of Italian researchers discovered a new role for type I interferon, in which it improves the ability of dendritic cells to stimulate an immune response against the bacterium known to cause tuberculosis. The researchers speculate that type I interferon may give the current vaccine the "boost" necessary to elicit a protective immunity against the mycobacterium tuberculosis.

"The results from our work on the novel role of type I interferons should open new perspectives in their use as a vaccine adjuvant," said Eliana M. Coccia, the senior researcher involved in the work.

Coccia and her colleagues made this discovery by obtaining human dendritic cells from the blood of healthy volunteers. The cells were divided in two groups: one of which was left untreated while the other was stimulated with type I interferon (IFN-beta). After four hours, both groups were treated with the tuberculosis vaccine. A day later, the researchers analyzed the cells and found that those pretreated with type I interferon had improved function over those from the untreated group. This suggests that type I interferon may play a role in improving the vaccine's ability to prevent tuberculosis.

"Because advances in research, medicine, and technology seem to happen on a daily basis, it's easy to forget that people still struggle against diseases like tuberculosis," said E. John Wherry, Deputy Editor of the Journal of Leukocyte Biology. "The finding described in this study suggest that type I interferon, an immune modulator normally associated with viral infections, could have great clinical benefit for people suffering from tuberculosis."

According to the U.S. Centers for Disease Control and Prevention, one third of the world's population is infected with the tuberculosis, with nearly 9 million people getting sick with the disease each year. Of those 9 million, almost 2 million die. The disease can spread through the air, and it usually affects the lungs. Without treatment, tuberculosis is fatal. The BCG vaccine for tuberculosis is used in many countries, but not generally recommended in the United States. The vaccine is not completely effective in preventing tuberculosis, making it imperative for scientists to find ways to improve its efficacy.


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. National Organization for Rare Disorders To Partner With Discovery Health and MYSTERY DIAGNOSIS for Rare Disease Day 2009
2. GlycoMeds Discovery Yields Early Warning Test for Cancer
3. MDS Analytical Technologies Laser Capture Microdissection Helps Facilitate Discovery of Potential New Colon-Cancer Biomarker
4. Discovery Health Uncovers the Truth With Its Mystery March Programming Event
5. This February Discovery en Espanol Delves Into The Subconscious World of Attraction in Science of Sex Appeal
6. Cancer-Causing Gene Discovery Suggests New Therapies
7. The 2009 Damon Runyon-Rachleff Innovation Award Granted for Pioneering Ideas for Early Detection of Ovarian and Lung Cancers, Bone Marrow Transplant Safety, and Discovery of New Genetic Markers for Cancer
8. Zassi Medical Evolutions Launches New Online Company That Uses Business DNA to Deliver Advanced Discovery, Collaboration, and Business Intelligence Tools to the Medical Device Industry
9. American Asthma Foundation Announces Breakthrough Discovery
10. Life Sciences Discovery awards health research program grants
11. MaxCyte Presents a Panel Discussion With Industry Experts on the Challenges in Developing Cell-Based Screening Assays for Drug Discovery - LIVE Q&A to Follow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... ... On May 24, the Congressional Budget Office (CBO) projected that the amended ... would result in 23 million Americans losing their health insurance by 2026 as compared ... Affordable Care Act (ACA). , “It is clear from the CBO analysis that ...
(Date:5/26/2017)... CA (PRWEB) , ... May 26, 2017 , ... Dr. ... is proud to announce a new, informational blog post on insurance options. If a ... checking insurance plans may help save time and money. Visiting an in-network provider for ...
(Date:5/26/2017)... ... May 26, 2017 , ... “Cactus Jack: Against All Odds”: ... many others. “Cactus Jack: Against All Odds” is the creation of published author, ... Hubbard is married to Jack Carlisle’s third child Jane. Walter. Walter and Jane ...
(Date:5/24/2017)... , ... May 24, 2017 , ... Altec ... participation in nVerge 2017 – a one-day technology conference in San Diego, CA. ... solution, which allows users to fully utilize and enhance their Sage ERP solutions by ...
(Date:5/24/2017)... DC (PRWEB) , ... May 24, 2017 , ... ... Center for Global Policy Solutions is vehemently opposed to Donald Trump’s budget, “A ... formula for despair that inspires fear, demonizes the poor, marginalizes underserved populations, undermines ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... , May 5, 2017   Provista , a ... more than 200,000 customers, today announced Jim Cunniff ... wealth of executive and business experience to Provista, including most ... pharmacy in California . He assumed his ... "Jim is a great fit for Provista," says Jody ...
(Date:5/4/2017)... , May 4, 2017  A recent ... Control, Ultraviolet-C light as a means ... SmartUVC,s ability to reduce bioburden on anesthesia workstations. ... reduction on high-touch, complex medical equipment surfaces contaminated ... infections. "This study further validates the ...
(Date:5/4/2017)... WAYNE, Pa. , May 4, 2017 /PRNewswire/ ... made from thermoplastics and other highly-engineered materials, is ... Microextrusion tubing has been developed in recent ... neurovascular interventional therapies and surgical applications. More expensive ... used to produce microextrusion tubing due to their ...
Breaking Medicine Technology: