Navigation Links
New discovery brings hope to treatment of lymphatic diseases
Date:8/10/2009

LEXINGTON, Ky. (Aug. 10, 2009) − Researchers in the laboratory of Dr. Jayakrishna Ambati at the University of Kentucky have discovered the first naturally occurring molecule that selectively blocks lymphatic vessel growth. In an article in the Aug. 9, 2009 online edition of Nature Medicine, they report the identification of a new molecule known as soluble VEGFR-2 that blocks lymphangiogenesis the growth of lymphatics but not blood vessel growth.

The twin circulatory systems of mammals - blood and lymphatic - are intricately intertwined, both anatomically and functionally. Until now it has been difficult to selectively target one without affecting the other. The lymphatic vessel network is essential for transporting fluids, molecules, and immune cells. It is crucial for wound healing and immune defense. Disturbances in the lymphatics are involved in diseases as varied as lymphedema, transplant rejection, and tumor metastasis, which collectively affect hundreds of millions of people worldwide.

This article, whose lead author is Dr. Romulo Albuquerque, currently a medical student in the UK College of Medicine, showed that soluble VEGFR-2 specifically blocks lymphatic vessel growth both during development and following injury by blocking VEGF-C, a powerful lymphatic growth factor. It also reports that loss of soluble VEGFR-2 during development led to the spontaneous invasion of lymphatic vessels, but not blood vessels, into the cornea, solving the long-standing mystery of why the cornea is normally devoid of lymphatics. Soluble VEGFR-2 was also required for normal development of lymphatics in the skin.

Importantly, administration of soluble VEGFR-2 to mice following corneal transplantation nearly eliminated graft rejection. This finding might also be applicable in kidney transplant rejection because it is known that lymphatic vessels are the culprit in the rejection of that organ as well. In addition, it challenges the prevailing dogma
'/>"/>

Contact: Ann Blackford
ann.blackford@uky.edu
859-312-3587
University of Kentucky
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Immune System Gene Discovery Sheds Light on Staph Infections
2. Cell Discovery May Bring Science Closer to Diabetes Cure
3. The Psychology of Frailty: An Identity Crisis Among the Elderly - Alzheimers Drug Discovery Foundations Dr. Howard Fillit to Co-Chair Symposium
4. Toronto researchers discovery points to a new treatment avenue for acute myeloid leukemia
5. Scientists Gather to Discuss Novel Uses of Caliper Life Sciences Discovery Platforms and Technology
6. Discovery Points to Regulation of Calcium Metabolism
7. IDRI Awarded $314,500 Grant From Murdock Trust to Expand TB Drug Discovery Program
8. Asthma Discovery May Lead to Better Treatments
9. Microsoft to Showcase Clinical Trial Solutions From Discovery to Approvals at Drug Information Associations 2009 Annual Meeting
10. Gaiam and Discovery Communications Announce Exclusive Licensing Deal
11. Mayo Genomic Discovery: Protecting Kidney Function During Heart Failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Best Cheap Hosting USA is among the most ... recently announced that iPower ( http://www.best-cheap-hosting-usa.com/go/iPower/ ) is the ... the world. , “iPower is one of the most ... various kinds of useful products for new and old ... customer service and a number of features which will ...
(Date:10/22/2014)... of Prussia, PA (PRWEB) October 22, 2014 ... is recognized as an industry leader with over 25 ... award winning team leader in the areas related to ... addition, Mr. Carlson is an Editorial Advisory Board member ... Healthcare Council Educator. Blue Fin Group is a ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. ... men may lead to increased blood pressure, according to a ... rise in blood pressure for young adult women or for ... women drank lightly or moderately, their risk of high blood ... finding parallels studies in older adult men and women," said ...
(Date:10/20/2014)... The newly updated Worldwide Medical Market Forecasts to ... figures and forecasts on the global medical markets. , ... the Worldwide Medical Market Forecasts to 2019 ... the worldwide medical market to reveal key insights into ... for 2010-2019, covering each country market individually, allowing you ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Women’s health ... in Obstetrics & Gynecology of Columbus, Inc., A Division ... healthcare services to more than 100,000 patients annually. Dr. ... all ages and stages of a women’s life. She ... locations in Westerville and Dublin. , Dr. Murphy ...
Breaking Medicine News(10 mins):Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 4Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3
... research suggests that testosterone replacement therapy for men with ... the prostate gland, contrary to some reports that this ... the November 15 issue of JAMA, a theme issue ... of the Urological Sciences Research Foundation and University of ...
... completely prevented the development of bone tumors in 50 ... providing early evidence that it could treat, or thwart, ... a number of cancers when they start to spread. ... D. Anderson Cancer Center reported in the journal Cancer ...
... symptoms who received a combination therapy were more likely to ... medication, according to a study in the November 15 issue ... ,Steven A. Kaplan, M.D., of Weill Cornell Medical College, ... a JAMA media briefing on men's health in New York. ...
... Family Welfare Minister has said that to shut out ... name of safety would be// against the interest of ... two day International Conclave on Traditional Medicine, which he ... society we live in today, a significant segment of ...
... been sequencing the genome of an organism called Mycobacterium-w ... complete// genome that holds promise in the treatment of ... evidence that a vaccine made from killed Mw drastically ... resistant (MDR) variety is driving this project more than ...
... medical research team looking for a cure for Duchenne Muscular ... submitted their findings// recently. ,The Stem cell Studies ... hope for those who suffer from the disease. ... genetic origin that results in muscle wasting which usually ...
Cached Medicine News:Health News:Testosterone Replacement Therapy Appears Safe for Prostate 2Health News:"Trojan Horse" Agent Halts Bone Metastasis in Mice 2Health News:"Trojan Horse" Agent Halts Bone Metastasis in Mice 3Health News:Combination Therapy More Effective for Treating Lower Urinary Tract Symptoms 2Health News:Two Day International Conclave on Traditional Medicine Inaugurated 2Health News:Two Day International Conclave on Traditional Medicine Inaugurated 3Health News:India Finds New Use for an Old Bug 2Health News:India Finds New Use for an Old Bug 3
(Date:10/22/2014)... N.J. , Oct. 22, 2014  Rescheduling ... major transformation in the pain market, according to ... Insights, Inc., a firm providing market research and ... Photo - http://photos.prnewswire.com/prnh/20141021/153440 ... scheduling change for hydrocodone combination products from Schedule ...
(Date:10/22/2014)... 2014   Reproductive Medicine Associates of New ... field of infertility, presents new clinical research examining ... research abstract, released during the 70 th ... in Honolulu, Hawaii , combines ... (SGD) pre-implantation genetic diagnosis (PGD). Results ...
(Date:10/22/2014)... Inc. (NYSE: CRY ), a leading medical ... vascular surgery, announced today that James Patrick (Pat) ... elected to the Company,s Board of Directors, effective October ... Executive Chairman of CryoLife, stated, "Since joining the Company in ... who is well positioned to maximize CryoLife,s potential.  His ...
Breaking Medicine Technology:Hydrocodone: Rescheduled, Repositioned & Reinvented 2Hydrocodone: Rescheduled, Repositioned & Reinvented 3New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3Pat Mackin Joins CryoLife Board of Directors 2Pat Mackin Joins CryoLife Board of Directors 3
... Presented in Spine, Lung, Liver and Prostate Treatment Emphasized the Benefits of ... , ... ARAY ), a global leader in the field of radiosurgery, today ... Radiotherapy Workshop, held in Brussels, Belgium on May 28 ...
... July 6 Questcor Pharmaceuticals, Inc. (NASDAQ:  QCOR) announced today ... Board of Directors. Dr. Blutt, 53, is the Founder and Chief Executive ... that is a shareholder of Questcor. Dr. Blutt is also board-certified in ... Medical College. , , , ...
Cached Medicine Technology:Presentations at the Third European Stereotactic Radiation Therapy and Whole Body Radiotherapy Workshop Highlight Clinical Outcomes and Emerging Trends 2Presentations at the Third European Stereotactic Radiation Therapy and Whole Body Radiotherapy Workshop Highlight Clinical Outcomes and Emerging Trends 3Presentations at the Third European Stereotactic Radiation Therapy and Whole Body Radiotherapy Workshop Highlight Clinical Outcomes and Emerging Trends 4Presentations at the Third European Stereotactic Radiation Therapy and Whole Body Radiotherapy Workshop Highlight Clinical Outcomes and Emerging Trends 5Mitchell J. Blutt, M.D. Appointed to Questcor Board of Directors 2Mitchell J. Blutt, M.D. Appointed to Questcor Board of Directors 3Mitchell J. Blutt, M.D. Appointed to Questcor Board of Directors 4Mitchell J. Blutt, M.D. Appointed to Questcor Board of Directors 5
... drainage from the ureteropelvic junction to the ... ease of placement and patient compliance. The ... repositioning and ease of removal. AQ® is ... when activated, attracts and holds water and ...
The ARC Laser MISC combines a pharo unit + Lyla laser module = Photolysis....
... IgM Capture ELISA is for the qualitative ... recombinant antigens (WNRA) in serum as an ... West Nile virus infection in patients with ... must be confirmed by Plaque Reduction Neutralization ...
Adult; dilates 6.0 to 34.0 French; individually packaged, sterile....
Medicine Products: