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New discovery about growth factor can be breakthrough for cancer research
Date:9/2/2008

ase, which, when activated, places short little protein chains on itself and other proteins. TRAF6 therefore functions as a switch that can determine what signals should be turned on in the cell. TRAF6 is used by TGF- to be specifically able to activate a kinase called TAK1, which subsequently activates other so-called stress-activated kinases, leading to cell death.

The discovery that TGF- makes use of TRAF6 to activate signal paths in cells opens up an entirely new landscape for future research. The makes it possible to develop new treatment strategies for advanced cancers that are dependent on TGF- , for example in advanced cases of breast and prostate cancer.


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Contact: Marene Landstrm
Marene.Landstrom@genpat.uu.se
46-070-231-634
Uppsala University
Source:Eurekalert

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