Navigation Links
New discovery about growth factor can be breakthrough for cancer research
Date:9/2/2008

A research team at the Ludwig Institute and Uppsala University has discovered an entirely new signal path for a growth factor that is of crucial importance for the survival and growth of cancer cells. This discovery, published in todays issue of Nature Cell Biology, opens up an entirely new landscape for research on breast and prostate cancer, among other types.

Our cells ability to understand signals from various growth factors is critical for normal fetal development. The aggressiveness and capacity for survival in cancer cells are also governed by a number of growth factors, with transforming growth factor b (TGF-b) playing a prominent role. In the present study, researchers at the Ludwig Institute for Cancer Research and the Department of Genetics and Pathology, Uppsala University, have identified an entirely new signal path that is regulated by TGF-b.

This discovery is of tremendous importance for our ability to identify what signal paths TGF-b uses to inhibit the growth of cells, or to stimulate the ability of cancer cells to survive and metastasize, says Marene Landstrm, who directed the study.

TGF-b conveys its signal to the inside of the cell via receptors bound to the cell membrane in a way that is similar in the great majority of animals. Just over ten years ago, scientists discovered so-called Smad proteins, which serve as unique messengers for the active TGF-b signal. These proteins are activated when phosphate groups bind to them in a manner that is dependent on enzyme activity (of serine-threonine kinases) in the TGF-b receptors.

The new signal path that the research team has now identified is regulated quite independently of this serine-threonine kinase activity, which makes the discovery published in the article extremely interesting. The study shows that the receptors are used instead to activate another enzyme, TRAF6, which binds to the complex of receptors. TRAF6 is a so-called ubiquitin-ligase, which, when activated, places short little protein chains on itself and other proteins. TRAF6 therefore functions as a switch that can determine what signals should be turned on in the cell. TRAF6 is used by TGF- to be specifically able to activate a kinase called TAK1, which subsequently activates other so-called stress-activated kinases, leading to cell death.

The discovery that TGF- makes use of TRAF6 to activate signal paths in cells opens up an entirely new landscape for future research. The makes it possible to develop new treatment strategies for advanced cancers that are dependent on TGF- , for example in advanced cases of breast and prostate cancer.


'/>"/>

Contact: Marene Landstrm
Marene.Landstrom@genpat.uu.se
46-070-231-634
Uppsala University
Source:Eurekalert

Related medicine news :

1. Discovery of sugar sensor in intestine could benefit diabetes
2. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
3. Stem cell research produces a key discovery for Fragile X Syndrome
4. Welch Foundation gives $1.6 million for drug discovery research
5. New discovery leaves blood-doping athletes scratching their heads
6. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
7. New discovery leaves blood-doping athletes scratching their heads
8. Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
9. Discovery supports theory of Alzheimers disease as form of diabetes
10. Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits
11. New discovery may improve treatment of one of the worlds leading causes of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... (PRWEB) May 24, ... new members of its Advisory Board. Joining the Grow Healthy ... “All three of them embody the mission of our organization and ... fortunate to have them as we continue to expand our footprint ...
(Date:5/24/2016)... ... May 24, 2016 , ... Boyd Industries, a leading ... Unit® (CDU), a groundbreaking new product for pediatric dentistry , at AAPD 2016, ... San Antonio, TX May 26-29. The Concealed Delivery Unit keeps dental hand pieces and ...
(Date:5/24/2016)... ... May 24, 2016 , ... Eggsurance, ... the official relaunch of its community and education hub for women considering fertility ... is to create a safe and welcoming place for women to find cycle ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... Jonathan (Jon) Otterstatter to its board of directors. Otterstatter is co-founder, president ... the development of technological innovations that lead to broad-based healthcare solutions. , “Jon ...
(Date:5/24/2016)... Pass, OR (PRWEB) , ... May 24, 2016 ... ... Kleyne welcomed Peggy Kinst, a wellness specialist for forty years and a trainer ... on the Sharon Kleyne Hour Radio Talk Show on May 16, 2016. , ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... , May 23, 2016 Clarifying ... Diagnostics and Monitoring, and Vision Care What ... areas are going to grow at the fastest rates? ... to 2026, assessing data, trends, opportunities and prospects. ... and graphs. Discover the most lucrative areas in the ...
(Date:5/23/2016)... 23, 2016 Gamida Cell, a ... of cancer and orphan genetic diseases, announced today it ... million from the Israel Innovation Authority (formerly the Office ... Economy and Industry. The mission of the Israel Innovation ... industries, including science and technology, while stimulating economic growth. ...
(Date:5/20/2016)... May 20, 2016 ReportsnReports.com ... to Medical Devices of its online business intelligence ... on the current state of the Titrator industry. ... industry like definitions, classifications, Specifications, applications and industry ... process like Raw Material Suppliers, Equipment Suppliers, Manufacturing ...
Breaking Medicine Technology: