Navigation Links
New discovery about growth factor can be breakthrough for cancer research
Date:9/2/2008

A research team at the Ludwig Institute and Uppsala University has discovered an entirely new signal path for a growth factor that is of crucial importance for the survival and growth of cancer cells. This discovery, published in todays issue of Nature Cell Biology, opens up an entirely new landscape for research on breast and prostate cancer, among other types.

Our cells ability to understand signals from various growth factors is critical for normal fetal development. The aggressiveness and capacity for survival in cancer cells are also governed by a number of growth factors, with transforming growth factor b (TGF-b) playing a prominent role. In the present study, researchers at the Ludwig Institute for Cancer Research and the Department of Genetics and Pathology, Uppsala University, have identified an entirely new signal path that is regulated by TGF-b.

This discovery is of tremendous importance for our ability to identify what signal paths TGF-b uses to inhibit the growth of cells, or to stimulate the ability of cancer cells to survive and metastasize, says Marene Landstrm, who directed the study.

TGF-b conveys its signal to the inside of the cell via receptors bound to the cell membrane in a way that is similar in the great majority of animals. Just over ten years ago, scientists discovered so-called Smad proteins, which serve as unique messengers for the active TGF-b signal. These proteins are activated when phosphate groups bind to them in a manner that is dependent on enzyme activity (of serine-threonine kinases) in the TGF-b receptors.

The new signal path that the research team has now identified is regulated quite independently of this serine-threonine kinase activity, which makes the discovery published in the article extremely interesting. The study shows that the receptors are used instead to activate another enzyme, TRAF6, which binds to the complex of receptors. TRAF6 is a so-called ubiquitin-ligase, which, when activated, places short little protein chains on itself and other proteins. TRAF6 therefore functions as a switch that can determine what signals should be turned on in the cell. TRAF6 is used by TGF- to be specifically able to activate a kinase called TAK1, which subsequently activates other so-called stress-activated kinases, leading to cell death.

The discovery that TGF- makes use of TRAF6 to activate signal paths in cells opens up an entirely new landscape for future research. The makes it possible to develop new treatment strategies for advanced cancers that are dependent on TGF- , for example in advanced cases of breast and prostate cancer.


'/>"/>

Contact: Marene Landstrm
Marene.Landstrom@genpat.uu.se
46-070-231-634
Uppsala University
Source:Eurekalert

Related medicine news :

1. Discovery of sugar sensor in intestine could benefit diabetes
2. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
3. Stem cell research produces a key discovery for Fragile X Syndrome
4. Welch Foundation gives $1.6 million for drug discovery research
5. New discovery leaves blood-doping athletes scratching their heads
6. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
7. New discovery leaves blood-doping athletes scratching their heads
8. Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
9. Discovery supports theory of Alzheimers disease as form of diabetes
10. Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits
11. New discovery may improve treatment of one of the worlds leading causes of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... actively feeding the Frederick area economy by obtaining investment capital for emerging technology ... past 2½ years that have already resulted in more than a million dollars ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
Breaking Medicine Technology: