Navigation Links
New discoveries linking gut bacteria with cholesterol metabolism give hope for the future
Date:2/19/2013

Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, show that cholesterol metabolism is regulated by bacteria in the small intestine. These findings may be important for the development of new drugs for cardiovascular disease.

It is well established that cholesterol is the major risk factor for cardiovascular disease. Cholesterol which is mainly synthesized in the body but also obtained from dietary sources is converted to bile acids in the liver, which are then secreted into the intestine and either removed from the body or recycled back to the liver.

The influence of gut bacteria on human health and disease is a rapidly expanding research area. Fredrick Bckhed's research group is a leader in this field and is investigating how gut bacteria are linked to lifestyle diseases such as obesity, diabetes and cardiovascular disease.

In a study published in the prestigious journal Cell Metabolism, they show that gut bacteria reduce bile acid synthesis in the liver by signaling through a specific protein, known as the FXR receptor, in the small intestine.

'Drugs that reduce cholesterol levels have, in recent years, greatly reduced deaths from cardiovascular disease. Our study is a step forward because we have shown how gut bacteria regulate the formation of bile acids from cholesterol', says Sama Sayin, medical doctor and PhD student at the Sahlgrenska Academy, University of Gothenburg, and the study's first author.

The FXR receptor not only affects cholesterol metabolism but is also involved in the body's sugar and fat metabolism.

'If future research can identify the specific bacteria that affect FXR signaling in the gut, this could lead to new ways to treat diabetes and cardiovascular disease', says Fredrik Bckhed, professor at the Sahlgrenska Academy, , University of Gothenburg, who led the study.


'/>"/>

Contact: Fredrick Bckhed
fredrik.backhed@wlab.gu.se
46-070-218-2355
University of Gothenburg
Source:Eurekalert

Page: 1

Related medicine news :

1. $50 million to speed discoveries for patients
2. Register now! San Diego meeting will showcase latest aging discoveries
3. Expanding database enables discoveries in emerging field of metabolomics
4. Barrow researchers use magic for discoveries
5. HypothyroidMom.com Reveals Research Linking Hypothyroidism to the Deadliest Diseases of Our Time
6. Atlanta LASIK Surgeon Publishes Response to New Study on Blinking
7. MyBloodWorks Creator Glen Ogle Comments on New Study Linking Hypertension During Pregnancy to Later Heart Trouble
8. Researchers discover regulator linking exercise to bigger, stronger muscles
9. Associations linking weight to breast cancer survival vary by race/ethnicity
10. Researchers develop secure protocol for linking data registries for HPV surveillance
11. Study identifies factors associated with eradication of bacteria linked to gastric cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... , ... The 12th session of the Silicon Valley BioTalks will take place ... CA. This Bay Area biotech event will focus on “Setting Up Early Stage Clinical ... company Hallux, biopharma Apexigen, Contract Research Organization (CRO) Experien Group, and Electronic Data Capture ...
(Date:5/25/2016)... ... May 25, 2016 , ... “We are very pleased to ... Advisors. “Brad brings significant experience advising healthcare provider clients throughout the country. As ... implementation of MACRA, we believe that continuing to add professionals with deep experience ...
(Date:5/25/2016)... ... 25, 2016 , ... The Georgia State University College of Law new building ... Design Commission. , The annual award recognizes projects, programs, individuals and organizations that have ... of its physical heritage and the balance between the old and the new. , ...
(Date:5/25/2016)... Marne, Michigan (PRWEB) , ... May 25, 2016 ... ... abuse located in Central Michigan, has produced another video highlighting one of the ... their Martial Arts class. Sensei Ed Taylor, a 5 th Degree Black Belt ...
(Date:5/25/2016)... ... 25, 2016 , ... According to an article published May 5th on The Daily ... their breath. In fact, it found that more than a third cited unappealing breath a ... by pungent foods or a failure to brush after meals, can typically be attributed to ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... Germany and GERMANTOWN, Maryland ... (NASDAQ: QGEN ; Frankfurt Prime Standard: QIA) today ... co-development agreement with Therawis Diagnostics GmbH to develop and commercialize ... develop and market PITX2 as a marker to predict effectiveness ... cancer patients. "We are pleased to partner with ...
(Date:5/25/2016)...  According to Kalorama Information, the world market ... Though these are challenging times in the market, ... for companies that remain optimistic and seek innovation.  ... prospects medical device companies spend a higher percentage ... than do companies in other industries.  Also, in ...
(Date:5/25/2016)... CORAL SPRINGS, Florida , May 25, 2016 /PRNewswire/ ... Marijuana Business Conference & Expo earlier this month, the ... undeniable. As revenues continue to climb into the billions, ... to the newly released 4th Edition State of Legal ... New Frontier, a cannabis-focused data-analysis firm, much of the ...
Breaking Medicine Technology: