Navigation Links
New discoveries linking gut bacteria with cholesterol metabolism give hope for the future
Date:2/19/2013

Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, show that cholesterol metabolism is regulated by bacteria in the small intestine. These findings may be important for the development of new drugs for cardiovascular disease.

It is well established that cholesterol is the major risk factor for cardiovascular disease. Cholesterol which is mainly synthesized in the body but also obtained from dietary sources is converted to bile acids in the liver, which are then secreted into the intestine and either removed from the body or recycled back to the liver.

The influence of gut bacteria on human health and disease is a rapidly expanding research area. Fredrick Bckhed's research group is a leader in this field and is investigating how gut bacteria are linked to lifestyle diseases such as obesity, diabetes and cardiovascular disease.

In a study published in the prestigious journal Cell Metabolism, they show that gut bacteria reduce bile acid synthesis in the liver by signaling through a specific protein, known as the FXR receptor, in the small intestine.

'Drugs that reduce cholesterol levels have, in recent years, greatly reduced deaths from cardiovascular disease. Our study is a step forward because we have shown how gut bacteria regulate the formation of bile acids from cholesterol', says Sama Sayin, medical doctor and PhD student at the Sahlgrenska Academy, University of Gothenburg, and the study's first author.

The FXR receptor not only affects cholesterol metabolism but is also involved in the body's sugar and fat metabolism.

'If future research can identify the specific bacteria that affect FXR signaling in the gut, this could lead to new ways to treat diabetes and cardiovascular disease', says Fredrik Bckhed, professor at the Sahlgrenska Academy, , University of Gothenburg, who led the study.


'/>"/>

Contact: Fredrick Bckhed
fredrik.backhed@wlab.gu.se
46-070-218-2355
University of Gothenburg
Source:Eurekalert

Page: 1

Related medicine news :

1. $50 million to speed discoveries for patients
2. Register now! San Diego meeting will showcase latest aging discoveries
3. Expanding database enables discoveries in emerging field of metabolomics
4. Barrow researchers use magic for discoveries
5. HypothyroidMom.com Reveals Research Linking Hypothyroidism to the Deadliest Diseases of Our Time
6. Atlanta LASIK Surgeon Publishes Response to New Study on Blinking
7. MyBloodWorks Creator Glen Ogle Comments on New Study Linking Hypertension During Pregnancy to Later Heart Trouble
8. Researchers discover regulator linking exercise to bigger, stronger muscles
9. Associations linking weight to breast cancer survival vary by race/ethnicity
10. Researchers develop secure protocol for linking data registries for HPV surveillance
11. Study identifies factors associated with eradication of bacteria linked to gastric cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... August 01, 2014 The "Antimicrobial ... such as Zinc Oxide, Titanium Dioxide, and Zinc ... & Construction, Food & Beverages, Textiles, and others), ... - Global Trends and Forecasts to 2018" analyzes ... drivers, opportunities, and trends in the diverse geographical ...
(Date:8/1/2014)... parents worry about their children choking on small objects or ... Such was the case for 15-month-old Landon Jones who started ... "At the time, Landon had a cold so it ... illness or choking," recalled his mother, Ula Jones. But, ... his windpipe and had to be removed via surgery. Landon ...
(Date:8/1/2014)... 01, 2014 For years, proponents have ... recent study conducted by the Ohio State ... far behind in terms of their health and development, ... what’s best for their baby. So does this new ... Dr. Steven Shapiro , chair of Pediatrics at Abington ...
(Date:8/1/2014)... (BRONX, NY) Scientists at Albert Einstein ... that bacteria that aid in digestion help keep the ... journal Immunity , could yield new therapies for ... other disorders. , The research involved the intestinal microbiome, ... these microorganisms in promoting or preventing disease is a ...
(Date:8/1/2014)... today’s age, traditional learning methods are futile in helping ... need to be revamped, so that the necessary subject ... age of the internet, online learning resources act as ... systems help in the planning, implementation, and assessment of ... proving to be very useful and this trend is ...
Breaking Medicine News(10 mins):Health News:Antimicrobial Coatings Market Projected to Reach $2.9 Billion by 2018 – Report by MarketsandMarkets 2Health News:Antimicrobial Coatings Market Projected to Reach $2.9 Billion by 2018 – Report by MarketsandMarkets 3Health News:Antimicrobial Coatings Market Projected to Reach $2.9 Billion by 2018 – Report by MarketsandMarkets 4Health News:Food Is a Common Choking Hazard for Kids, Doctor Says 2Health News:Despite Recent Study, Abington Health Expert Encourages Breastfeeding 2Health News:Despite Recent Study, Abington Health Expert Encourages Breastfeeding 3Health News:'Normal' bacteria vital for keeping intestinal lining intact 2Health News:North America Learning Management System Market is Expected to Reach $5.13 Billion in 2018 - New Report by MicroMarket Monitor 2Health News:North America Learning Management System Market is Expected to Reach $5.13 Billion in 2018 - New Report by MicroMarket Monitor 3Health News:North America Learning Management System Market is Expected to Reach $5.13 Billion in 2018 - New Report by MicroMarket Monitor 4
... France's best-loved cheeses is in question after the two biggest ... untreated "raw" milk -- stopped production, citing health risks ... Lactalis and the Isigny Cooperative -- who together supplied 90 ... northwest region of Normandy -- have switched to using treated ...
... billion dollars) over the next eight years to the global ... to be published Thursday. ,Heidemarie Wieczorek-Zeul told ... to send a message to other member states during the ... Heiligendamm. ,"My appeal goes out to the other ...
... Hong Kong teenagers vibrates to the latest dance hit as a ... ,"Scream louder if you want more," a DJ shouts ... low-cut jeans throws his female partner onto his lap in a ... typical Friday night, but while many of the clubbers hail from ...
... Finnish Research study has found that exposure even a small ... serious and harmful impact on the cardiovascular system of a ... smoke can harm the childs arteries. ,Instead of relying ... the Finnish researchers used high-resolution ultrasound to check brachial artery ...
... old resident in New York, drank Boost Plus, a vitamin enriched ... ,When he woke up the next day, he had ... for medical advice and for treatment of the condition called severe ... is persistent, painful erection of the penis. Recurrent or severe episodes ...
... that the prison population in England and Wales reached a ... there were fewer than 300 cells available for new inmates. ... to house prisoners in some areas of the country. ... the BMAs Civil and Public Services Committee said: ...
Cached Medicine News:Health News:Fate of France's Cheeses in Doubt as Producers Cite Health Risks 2Health News:Fate of France's Cheeses in Doubt as Producers Cite Health Risks 3Health News:Drugs Lure Hong Kong Youth Across China Border 2Health News:Drugs Lure Hong Kong Youth Across China Border 3Health News:Prison Healthcare Under Strain as Overcrowding Crisis Worsens, Warns BMA 2
(Date:8/1/2014)... -- In the latest call for gender equity in ... 60 doctors and leading medical experts from across the ... and Drug Administration,s (FDA) decision to approve 26 drugs ... dysfunction compared with ZERO for women,s most common complaint, ... by approving the first-ever drug to treat Hypoactive Sexual ...
(Date:8/1/2014)... , August 1, 2014 ... Market by Type (Traditional Wound Closure, Anti infective), Basic ... (Artificial Skin & Skin Substitutes), Pressure Relief Devices, ... MarketsandMarkets, the global Wound Care Market is expected to ... in 2014, growing at a CAGR of 3.2% ...
(Date:8/1/2014)... PLYMOUTH MEETING, Pa. , Aug. 1, 2014 /PRNewswire/ ... that it will host a conference call to report ... 11, 2014 at 9:00 AM ET. CEO Dr. ... will discuss second quarter earnings, provide a corporate ... The update will include clinical development plans for VGX-3100, ...
Breaking Medicine Technology:60+ Doctors and Leading Medical Experts Sign an Open Letter Urging the FDA to Approve First-Ever Drug to Treat Women's Most Common Form of Sexual Dysfunction, notes Even the Score 260+ Doctors and Leading Medical Experts Sign an Open Letter Urging the FDA to Approve First-Ever Drug to Treat Women's Most Common Form of Sexual Dysfunction, notes Even the Score 3Wound Care Market Worth $18.3 Billion by 2019 2Wound Care Market Worth $18.3 Billion by 2019 3Inovio Pharmaceuticals to Host Second Quarter 2014 Financial Results Call on August 11, 2014 2Inovio Pharmaceuticals to Host Second Quarter 2014 Financial Results Call on August 11, 2014 3
... TEL AVIV, Israel, December 20, 2011 During ... Board of Governors of the Israel-U.S. Binational Industrial Research ... for nine new projects between Israeli and American companies. In ... private sector funding, boosting the total value of all projects ...
...  The National Urban League (NUL) and the League of United ... to resume negotiations and come to an agreement with Walgreens ... millions of Americans, especially in diverse and underserved communities, stand ... In an open letter to Express Scripts, ...
Cached Medicine Technology:BIRD - Israel-US Binational Industrial R&D Foundation to Invest $8.1 Million in Nine new Projects 2BIRD - Israel-US Binational Industrial R&D Foundation to Invest $8.1 Million in Nine new Projects 3The National Urban League and League of United Latin American Citizens Urge Express Scripts to Reach Agreement with Walgreens 2The National Urban League and League of United Latin American Citizens Urge Express Scripts to Reach Agreement with Walgreens 3
Iron FS Ferene for determination of iron in serum. Available with Calibrator: Trucal U and Controls: Trulab N, Trulab P. For automated systems....
Intended for the quantitative determination of iron in serum. Reaction: Endpoint. Wavelength: 595 nm. Linearity: 500 g/dL (89.5 mol/L). Two vials, liquid reagents....
HDL Cholesterol, liquid....
For the quantitative determination of high density lipoprotein (HDL) in human serum....
Medicine Products: