Navigation Links
New diagnostic and therapeutic techniques show potential for patients with metastasized melanoma

Reston, Va. (January 7, 2014) With low survival rates for patients with metastasized melanoma, accurate staging and effective treatments are critical to extending life. New research published in the Journal of Nuclear Medicine highlights the potential of newly developed radiopharmaceuticals with benzamide for the imaging of metastases and as a targeted systemic therapy.

Malignant melanoma is the fifth most common cancer in men and the sixth most common cancer in women, and its incidence rate is increasing rapidly. It accounts for nearly 80 percent of all deaths related to cutaneous cancer. When discovered early, localized melanoma can be cured by surgical removal. However, this cancer displays a strong tendency to metastasize and has very low survival rates for patients, with fewer than five percent surviving longer than five years.

In the study "123I-BZA2 as a Melanin-Targeted Radiotracer for the Identification of Melanoma Metastases: Results and Perspectives of a Multicenter Phase III Clinical Trial," researchers developed a specific single photon emission computed tomography (SPECT) radiopharmaceutical for malignant melanoma123I-BZA2. Imaging of patients with metastasized melanoma was then performed with both 18F-FDG positron emission tomography/computed tomography (PET/CT) and 123I-BZA2 SPECT to compare the accuracy in staging and restaging.

Eighty-seven patients were examined with a total of 86 metastatic lesions. In the analysis of lesions, the sensitivity for 18F-FDG for diagnosis of melanoma metastases was higher than that of 123I-BZA2 (80 percent vs. 23 percent). The specificity of 18F-FDG, however, was lower than 123I-BAZ2 (54 percent vs. 86 percent). The sensitivity and specificity of 123I-BAZ2 for the diagnosis of melanin-positive lesions were 75 percent and 70 percent, respectively.

"We have demonstrated that 123I-BZA2 tumor accumulation was clearly correlated to melanin content of the melanoma metastases. Thus, 123I -BZA2 could be theoretically used for the diagnosis of melanoma metastases," said Florent Cachin, MD, PhD, lead author of the study. "However, given its low sensitivity due to the high proportion of non-pigmented lesion in the natural course of metastatic melanoma, 123I- IBZA2 cannot be used for melanoma staging. Such results could appear discouraging, but the concept of melanin targeting may offer a real opportunity for therapy."

In the study "Radiopharmaceutical Therapy of Patients with Metastasized Melanoma with the Melanin-Binding Benzamide 131I-BA52," the first use of a melanoma-seeking agent for therapeutic application was analyzed. Researchers used a theranostic approach in which the same molecule was given first as a diagnostic isotope (123I-BA52) to identify the patients possibly profiting from therapy, and then as a therapeutic radiopharmaceutical (131I-BA52) for those patients who would benefit. Twenty-six patients were imaged with 123I-BA52, and nine patients were selected for therapy with 131I-BA52.

Some of the patients treated with 131I-BA52 were found to have a survival rate of more than two years. Researchers also found that higher treatment doses would have been tolerated in these patients, as only moderate side effects were observed. "We believe that the tracer could be useful in the setting of a combination therapy in patients with metastasized melanoma, especially when applied in earlier stages of the disease where the melanin production is higher as compared to later stages of the disease," noted Uwe Haberkorn, MD, lead author of the study.

Even though new treatments are now available, the prognosis for patients with metastatic melanoma remains very poor. "Innovative strategies are necessary to improve patients' survival. Research focused on innovating targeted-therapy reflects modern oncology, as new theranostic concepts. This strategy nicely illustrates the future of nuclear medicine oncology," said Cachin.


Contact: Susan Martonik
Society of Nuclear Medicine

Related medicine news :

1. Wimbledon Health Partners Adds 50 Physician Consultants to the Team to Meet Growing Diagnostic Testing Demand
2. Molecular Diagnostics Role in Cancer Testing Analyzed in In-demand TriMark Report Published at
3. Health Briefs TV Offers a View on Diagnostics Segment
4. Diagnostic ECG (DECG) Market Worth U.S. $4.1 Billion by 2014 - New Report by MarketsandMarket
5. Zamansky LLC Comments On the Settlement By Quest Diagnostics And LabCorp. Of America Of The Whistle-Blower Lawsuit
6. UK Clinical Chemistry and Immunodiagnostics Market Opportunities Discussed in New VPG Report Published at
7. Wimbledon Health Partners, the Leading On-Site Diagnostic Testing Organization, Welcomes New Corporate Leadership
8. Wimbledon Health Partners Rolls Out Two New Service Lines to Meet Diagnostic Testing Needs of Physicians Nationwide
9. PET Scans—The Next Diagnostic Miracle
10. Swallowing a diagnostic pill
11. BCC Research Publishes a New Report On Global Markets for Companion Diagnostics
Post Your Comments:
(Date:11/24/2015)... ... 2015 , ... Chiropractic student Katie Benson received a $2,500 ... Park, Kansas. Benson, a fifth-trimester student in the university’s College of Chiropractic, accepted ... 16. , “Katie is very excited and greatly appreciative to receive the Standard ...
(Date:11/24/2015)... ... November 24, 2015 , ... Sir ... customer service: the TrustDale certification. The award recognizes good companies for excellence in ... , tile and grout, and hard surface restoration company earned this recognition after ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... Bibliomotion ... Ford and Detroit Taught Me about Reinvention and Diversity by Nancy M. Schlichting, ... people suffer, with hospitals failing to adequately address the needs of patients and their ...
(Date:11/24/2015)... ... November 24, 2015 , ... Dr. Kevin Day, local family ... community stress less this holiday season. During the Indiana winter months, Vitamin D ... and the team at AlignLife want to help provide the tools needed to combat ...
(Date:11/24/2015)... IL (PRWEB) , ... November 24, 2015 , ... All her life, Don Peck’s mother ... Even her obituary said she might have been. After a 25-year search for information, ... voyager with whom she shared a last name. Turns out, it was Don’s father ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... st  Scientific Assembly and Annual Meeting of the Radiological ... in Chicago on Nov-29 th through ... st  Scientific Assembly and Annual Meeting of the Radiological Society of ... Chicago on Nov-29 th through Dec-4 th ... will present its revolutionary whole body CZT digital SPECT/CT solution at ...
(Date:11/24/2015)... 2015 Teledyne DALSA , a Teledyne Technologies ... will introduce its CMOS X-Ray detector for mammography ... to December 3, at McCormick Place in Chicago ... and interventional imaging will be on display in the South ... advanced CMOS X-Ray detectors is the industry benchmark for high ...
(Date:11/24/2015)... , Nov. 24, 2015  Boston Scientific Corporation ... the Oppenheimer 26th Annual Healthcare Conference on December 8, ... Susie Lisa , vice president, Investor Relations, will ... analyst beginning at approximately 8:35 a.m. ET. --> ... participate in a 30-minute question-and-answer session with the host ...
Breaking Medicine Technology: