Navigation Links
New device detects deadly lung disease
Date:7/23/2014

A scientist from the University of Exeter has developed a simple, cheap and highly accurate device for diagnosing a frequently fatal lung disease which attacks immune deficient individuals such as cancer patients and bone marrow transplant recipients.

The lateral-flow device (LFD), created by Professor Chris Thornton, detects invasive pulmonary aspergillosis, a notoriously difficult to diagnose disease caused by the fungus Aspergillus.

Invasive aspergillosis is a leading cause of death in acute leukaemia and bone marrow transplant patients, accounting for more than 200,000 life-threatening infections each year, with an associated mortality rate of up to 90%.

The new device which resembles a pregnancy test but uses a small blood sample will cost health authorities just 10 per test and will fit into routine hospital practices. It will potentially reduce the high rates of mortality and morbidity associated with the disease and enable better use of costly and toxic antifungal drugs.

Professor Thornton, of Biosciences, said: "Individuals with invasive pulmonary aspergillosis are often suffering from complex medical conditions and the symptoms, which include raised temperature, breathlessness, chest pain and fatigue, could be attributable to a number of other conditions. At present, it can take several days to identify the disease correctly due to the lack of accurate diagnostic tests, and the patient's health deteriorates significantly in the absence of appropriate treatment.

"The low cost, speed, ease-of-use and compatibility of the new device with standard hospital procedures means that the disease can be quickly and accurately monitored at the point-of-care using a simple blood test or with fluids collected during lung biopsy."

Professor Thornton and colleagues have published a number of clinical studies with hospitals in London, Germany, Austria and elsewhere in mainland Europe.

There is also an ongoing trial with leukaemia patients at the Royal Devon and Exeter Hospital under the care of Consultant Haematologist Dr Paul Kerr. He said: "We at the Exeter Leukaemia Unit are very proud to work with Dr Thornton and his team on this project; diagnosing this life-threatening infection is very difficult, and can involve either subjecting the patient to unpleasant and potentially dangerous investigations, or can result in the use of expensive and toxic medication that may not always be needed. It is very exciting to think that a simple laboratory test may allow us to greatly simplify this process in the future."

With financial support from the University and Angel funders, a spin-out company called ISCA Diagnostics Ltd was established to enable commercialisation of the test. Global marketing and distribution of the device is delivered through ISCA's partner company OLM Medical.

The lateral flow device will be being used in hospitals around the world from August. The test uses a highly specific monoclonal antibody to detect a diagnostic marker of active Aspergillus infection, meaning that doctors can more precisely identify patients developing the disease.

This success is a visible example of how University bench-to-bedside Research & Development can deliver commercial impact through academic, industry and private investor partnerships.

The work has received funding from the US National Institutes of Health, HEIF, private investors, and a global pharmaceuticals company.

Professor Thornton is a fungal immunologist with a specialist interest in hybridoma technology and immunodiagnostics. His recent research has concentrated on human infections by opportunistic fungal pathogens and their rapid detection using monoclonal antibodies.


'/>"/>

Contact: Eleanor Gaskarth
e.f.gaskarth@exeter.ac.uk
44-782-730-9332
University of Exeter
Source:Eurekalert  

Related medicine news :

1. Cardiovascular Prosthetic Devices Market in North America to 2020 Report Available at MarketOptimizer.org
2. InventHelp Inventor Develops Versatile Medical Testing Device (OCC-760)
3. Surging Obesity Rates Drives Demand for Bariatric (Obesity) Surgical Devices, According to New Report by Global Industry Analysts, Inc.
4. Introducing the Restful Jaw – The Only Device Designed to Protect the Patient’s Jaw
5. Medical Devices Market in India 2014 Trends and Analysis in Study Available at MarketReportsOnline.com
6. US Weight Loss Surgery Devices Market (Bariatric Surgery) Forecasts to 2020 New Report Available at ReportsnReports.com
7. FDAnews Announces Device Software Verification and Validation: Get Ready for a New Breed of Investigators, On-Demand Webinar, Aug. 12, 2014
8. United States Gynecological Devices Market to 2020 Forecasts Report Available at ReportsnReports.com
9. Global Electrodes for Medical Devices Market: Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019
10. Europe Cardiac Surgery Device Market Value to Go Beyond USD 3.4 Bn by 2020, According to iData Research Study Available at MarketPublishers.com
11. Reha Technology Launches the Armotion™, a Device for the Rehabilitation of the Upper Extremity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New device detects deadly lung disease
(Date:5/3/2016)... , ... May 03, 2016 , ... Elizabeth Murray has ... parrots to join her with one on her shoulder and one on her arm. ... parking lot because of years of mitral valve prolapse. , The valves of the ...
(Date:5/3/2016)... ... ... Excessive panting in the car or cowering when new guests arrive are ... only manifests itself as trembling or ‘tail between the legs,’ but a pet ... about it,” says Dr. Jim Lowe, technical services veterinarian for Tomlyn pet health products ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... been selected by Tidelands Health, a three hospital system in South Carolina, to ... on the lookout for technology that enhances communication, drives workflow efficiencies and improves ...
(Date:5/3/2016)... ... 2016 , ... Boston Children’s Hospital today announced its new pediatric Simulation (SIM) ... or rare procedures in an environment that looks and feels real. , Located in ... inventors and “hackers” to develop and test new devices or software platforms and see ...
(Date:5/3/2016)... OH (PRWEB) , ... May 03, 2016 , ... Each ... a leading cause of death across the United States and account for one death ... and mental impairments or are permanently disabled. HCR ManorCare is launching a video series ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)...   Click here for supplemental information regarding ... the nation,s largest independent specialty pharmacy, announced today ... acquire Valley Campus Pharmacy, Inc., doing business as ... pharmacy that provides individualized patient care, based in ... 2015, TNH generated approximately $400 million in revenue. ...
(Date:4/28/2016)... BURLINGAME, Calif. , April 28, 2016 /PRNewswire/ ... first-ever widely accessible breast and ovarian cancer risk ... cancer panel analyzing 30 genes that highly impact ... and women. Available today, the Color Test analyzes ... pancreatic, prostate, stomach, and uterine cancers. The Color ...
(Date:4/28/2016)... NEW YORK , April 28, 2016 ... of online consumer insights on healthcare, announced today that ... in their report Cool Vendor in Life Sciences, ... , April 15, 2016.  The report focuses on life-science- ... to gain insight from patients and doctors, confirm medication ...
Breaking Medicine Technology: